Q11CD0 (SAHH_MESSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosylhomocysteinase
EC=3.3.1.1

Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase

Gene names

Name:	ahcY
Ordered Locus Names:	Meso_3576

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563
Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563
Cofactor	Binds 1 NAD per subunit By similarity. HAMAP MF_00563
Pathway	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563
Subcellular location	Cytoplasm By similarity HAMAP MF_00563.
Sequence similarities	Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Adenosylhomocysteinase HAMAP MF_00563		PRO_1000024731
Regions
	Nucleotide binding	192 – 194	3	NAD By similarity
	Nucleotide binding	255 – 260	6	NAD By similarity
	Nucleotide binding	334 – 336	3	NAD By similarity
Sites
	Binding site	56	1	Substrate By similarity
	Binding site	131	1	Substrate By similarity
	Binding site	191	1	Substrate By similarity
	Binding site	221	1	Substrate By similarity
	Binding site	225	1	Substrate By similarity
	Binding site	226	1	NAD By similarity
	Binding site	278	1	NAD By similarity
	Binding site	313	1	NAD By similarity
	Binding site	379	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11CD0 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 2D5217D543BE535F	FASTA	465	50,894
	10 20 30 40 50 60 MAADDYVVAD MSLAAWGRKE IEIAETEMPG LMACREEFGE AKPLKGARIT GSLHMTIQTA 70 80 90 100 110 120 VLIETLKSLG AEVRWASCNI FSTQDHAAAA IAETGTPVFA VKGETLEEYW TYTDRIFQWP 130 140 150 160 170 180 DGQPSNMILD DGGDATMYIL LGARAEAGED VLSNPDGEEE EILFQQIKKR MAETPGFFTR 190 200 210 220 230 240 QRAAIRGVTE ETTTGVNRLY QLQKKGLLPF PAINVNDSVT KSKFDNKYGC KESLVDGIRR 250 260 270 280 290 300 ATDVMMAGKV AIVCGYGDVG KGSAQSLAGA GARVKVTEAD PICALQAAMD GFEVVTLDEA 310 320 330 340 350 360 IATADIIITA TGNKDVVSLD HMRKMKDMVI LGNIGHFDNE IQVAALRNFK WVNIKPQVDL 370 380 390 400 410 420 IEFPDGKRII LLSEGRLLNL GNATGHPSFV MSASFTNQVL AQIELWTRGS QYENKVYVLP 430 440 450 460 KHLDEKVARL HLAKLGANLT KLSPEQAAYI GVTPEGPFKP DHYRY

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BNC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG64945.1.
RefSeq	YP_676110.1. NC_008254.1.
3D structure databases
ProteinModelPortal	Q11CD0.
SMR	Q11CD0. Positions 5-465.
ModBase	Search...
Protein-protein interaction databases
STRING	Q11CD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4181405.
GenomeReviews	Gene locus Meso_3576 in contig CP000390_GR.
KEGG	mes:Meso_3576.
NMPDR	fig|266779.1.peg.960.
PATRIC	21347496. VBICheSp72577_4349.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0499.
HOGENOM	HBG352029.
OMA	SAQVWVT.
PhylomeDB	Q11CD0.
ProtClustDB	PRK05476.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_3576-MONOMER.
Family and domain databases
HAMAP	MF_00563. AdoHcyase. [Tree]
InterPro	IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
KO	K01251.
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMART	SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00936. AhcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAHH_MESSB

Accession

Primary (citable) accession number: Q11CD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program