Reviewed, UniProtKB/Swiss-Prot Q11C48 (ADD_MESSB)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	Meso_3659

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Adenosine deaminase HAMAP MF_00540		PRO_1000017666
Sites
	Active site	186	1	Potential
	Active site	234	1	Potential
	Active site	267	1	Potential
	Active site	268	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q11C48-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 58A2E1806AE4B0B3	FASTA	325	35,034
	10 20 30 40 50 60 MLLKAELHCH IEGAASPALV KAQARKYGAD ISSFIRGGAY YWQDFTTFLL AYDQAASLFR 70 80 90 100 110 120 TQEDYALLAE TYLKELAAGG AIYSEFFTSP DHAERAGLSP QAYTDGLAEG MVQAKAATGI 130 140 150 160 170 180 ESRMIVTGVR HFGPEAVEKA ARFAASCEHP LVTGFGMAGD ERAGHPRDFA YAFDIAREAG 190 200 210 220 230 240 LGISIHAGEF GGAESVEAAL DHIRPSRIGH GVRAIENPDL VRRIADEGVV LEVCPVSNVV 250 260 270 280 290 300 LKVFPEFARH PFPQLVAAGC RVTLNSDDPP HFHTSLAREY AVAAEYFGLD ETTLNAITST 310 320 AIEAAFVDEK TRAALFARLK PVVES

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG65027.1.
RefSeq	YP_676192.1.
3D structure databases
SMR	Q11C48. Positions 2-316.
ModBase	Search...
Protein-protein interaction databases
STRING	Q11C48.
Genome annotation databases
GeneID	4179536.
GenomeReviews	Gene locus Meso_3659 in contig CP000390_GR.
KEGG	mes:Meso_3659.
NMPDR	fig|266779.1.peg.878.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	GWFRFQR.
PhylomeDB	Q11C48.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_MESSB

Accession

Primary (citable) accession number: Q11C48

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	February 9, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)