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Q11C48 (ADE_MESSB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Ordered Locus Names:Meso_3659
OrganismMesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]
Taxonomic identifier266779 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Adenine deaminase HAMAP MF_01962
PRO_1000017666

Sites

Active site1891Proton donor By similarity
Metal binding81Zinc; catalytic By similarity
Metal binding101Zinc; catalytic By similarity
Metal binding1861Zinc; catalytic By similarity
Metal binding2671Zinc; catalytic By similarity
Binding site2681Substrate By similarity
Site2101Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q11C48 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 58A2E1806AE4B0B3

FASTA32535,034
        10         20         30         40         50         60 
MLLKAELHCH IEGAASPALV KAQARKYGAD ISSFIRGGAY YWQDFTTFLL AYDQAASLFR 

        70         80         90        100        110        120 
TQEDYALLAE TYLKELAAGG AIYSEFFTSP DHAERAGLSP QAYTDGLAEG MVQAKAATGI 

       130        140        150        160        170        180 
ESRMIVTGVR HFGPEAVEKA ARFAASCEHP LVTGFGMAGD ERAGHPRDFA YAFDIAREAG 

       190        200        210        220        230        240 
LGISIHAGEF GGAESVEAAL DHIRPSRIGH GVRAIENPDL VRRIADEGVV LEVCPVSNVV 

       250        260        270        280        290        300 
LKVFPEFARH PFPQLVAAGC RVTLNSDDPP HFHTSLAREY AVAAEYFGLD ETTLNAITST 

       310        320 
AIEAAFVDEK TRAALFARLK PVVES

« Hide

References

[1]"Complete sequence of chromosome of Mesorhizobium sp. BNC1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BNC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000390 Genomic DNA. Translation: ABG65027.1.
RefSeqYP_676192.1. NC_008254.1.

3D structure databases

ProteinModelPortalQ11C48.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ11C48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4179536.
GenomeReviewsGene locus Meso_3659 in contig CP000390_GR.
KEGGmes:Meso_3659.
NMPDRfig|266779.1.peg.878.
PATRIC21347668. VBICheSp72577_4434.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1816.
HOGENOMHBG630382.
OMAIVLECCP.
PhylomeDBQ11C48.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycMSP266779:MESO_3659-MONOMER.

Family and domain databases

HAMAPMF_01962. Adenine_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADE_MESSB
AccessionPrimary (citable) accession number: Q11C48
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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