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Q11BE3

- MASZ_CHESB

UniProt

Q11BE3 - MASZ_CHESB

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Protein
Malate synthase G
Gene
glcB, Meso_3915
Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei274 – 2741Acetyl-CoA By similarity
Binding sitei311 – 3111Acetyl-CoA By similarity
Active sitei338 – 3381Proton acceptor By similarity
Binding sitei338 – 3381Glyoxylate By similarity
Metal bindingi430 – 4301Magnesium By similarity
Binding sitei430 – 4301Glyoxylate By similarity
Metal bindingi458 – 4581Magnesium By similarity
Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei629 – 6291Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCSP266779:GI09-3980-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:Meso_3915
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
ProteomesiUP000001820: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Malate synthase GUniRule annotation
PRO_1000130891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei615 – 6151Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi266779.Meso_3915.

Structurei

3D structure databases

ProteinModelPortaliQ11BE3.
SMRiQ11BE3. Positions 2-720.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1252Acetyl-CoA binding By similarity
Regioni455 – 4584Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11BE3-1 [UniParc]FASTAAdd to Basket

« Hide

MTDRVEINGL KIARELHDFA MNEVLPGTGV DAETFWHSLS QIVHTLSPRN    50
RALLSKRDDL QAKIDAWHRA NRAPSDLQAY EAFLREIGYL LPEGPDFKVT 100
TSDVDPEISQ IAGPQLVVPV MNARYALNAA NARWGSLYDA LYGTDAIPET 150
AGAERGKGFN PQRGEKVIAW ARKFLDESIP LRNASWADAA RLSVKDGKLA 200
VDFDGAAADL ADPAQFTGYS GEADSPREVV LARNGLHVRI IIDRNHPIGS 250
TDRAGIADVV MEAALTTIMD CEDSVAAVDA EDKVLAYRNW LGLMKGDLEE 300
TFQKGGTTVT RKLNQDIRLT APDGSPIKLP GRSLMLVRNV GHLMTNPAIL 350
DRDGKEVPEG IMDAMFTALI ALHDIGPNGR RMNSRAGSMY VVKPKMHGPE 400
EVAFAVELFG SVEDALGMRP NTIKMGIMDE ERRTTVNLKE CIRAASERVV 450
FINTGFLDRT GDEIHTSMEA GPMIRKGDMK QSTWIAAYEN WNVDIGLLCG 500
LSGRAQIGKG MWAMPDLMAA MLDQKIAHPK AGANTAWVPS PTAATLHATH 550
YHQVDVKAVQ EGLKSRTRAK LGDILSIPVA VRPNWSPEDI RQELDNNAQG 600
ILGYVVRWID QGVGCSKVPD INNVGLMEDR ATLRISSQHI ANWLHHGVVT 650
PEQVMETMKR MAEVVDSQNA GDPDYEPIAP NFEDSIAFQA ACDLVFKGRE 700
QPNGYTEPVL HARRLQKKAQ DRKGAAADSS RG 732
Length:732
Mass (Da):80,279
Last modified:August 22, 2006 - v1
Checksum:i7B62E9807F370B74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000390 Genomic DNA. Translation: ABG65282.1.
RefSeqiWP_011583223.1. NC_008254.1.
YP_676447.1. NC_008254.1.

Genome annotation databases

EnsemblBacteriaiABG65282; ABG65282; Meso_3915.
GeneIDi4181887.
KEGGimes:Meso_3915.
PATRICi21348220. VBICheSp72577_4708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000390 Genomic DNA. Translation: ABG65282.1 .
RefSeqi WP_011583223.1. NC_008254.1.
YP_676447.1. NC_008254.1.

3D structure databases

ProteinModelPortali Q11BE3.
SMRi Q11BE3. Positions 2-720.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266779.Meso_3915.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG65282 ; ABG65282 ; Meso_3915 .
GeneIDi 4181887.
KEGGi mes:Meso_3915.
PATRICi 21348220. VBICheSp72577_4708.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci CSP266779:GI09-3980-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BNC1.

Entry informationi

Entry nameiMASZ_CHESB
AccessioniPrimary (citable) accession number: Q11BE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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