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Protein

Malate synthase G

Gene

glcB

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glyoxylate cycle

This protein is involved in step 2 of the subpathway that synthesizes (S)-malate from isocitrate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Malate synthase G (glcB)
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117Acetyl-CoA; via carbonyl oxygenUniRule annotation1
Binding sitei274Acetyl-CoAUniRule annotation1
Binding sitei311Acetyl-CoAUniRule annotation1
Active sitei338Proton acceptorUniRule annotation1
Binding sitei338GlyoxylateUniRule annotation1
Metal bindingi430MagnesiumUniRule annotation1
Binding sitei430GlyoxylateUniRule annotation1
Metal bindingi458MagnesiumUniRule annotation1
Binding sitei539Acetyl-CoA; via carbonyl oxygenUniRule annotation1
Active sitei629Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:Meso_3915
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
Proteomesi
  • UP000001820 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001308911 – 732Malate synthase GAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei615Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Proteomic databases

PRIDEiQ11BE3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266779.Meso_3915

Structurei

3D structure databases

ProteinModelPortaliQ11BE3
SMRiQ11BE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 125Acetyl-CoA bindingUniRule annotation2
Regioni455 – 458Glyoxylate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP3 Bacteria
COG2225 LUCA
HOGENOMiHOG000220740
KOiK01638
OMAiTEPVLHA
OrthoDBiPOG091H05P0

Family and domain databases

CDDicd00728 malate_synt_G, 1 hit
Gene3Di2.170.170.11, 1 hit
HAMAPiMF_00641 Malate_synth_G, 1 hit
InterProiView protein in InterPro
IPR011076 Malate_synth-like_sf
IPR023310 Malate_synth_G_beta_sub_dom
IPR001465 Malate_synthase
IPR006253 Malate_synthG
PANTHERiPTHR42739 PTHR42739, 1 hit
PfamiView protein in Pfam
PF01274 Malate_synthase, 1 hit
SUPFAMiSSF51645 SSF51645, 1 hit
TIGRFAMsiTIGR01345 malate_syn_G, 1 hit

Sequencei

Sequence statusi: Complete.

Q11BE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRVEINGL KIARELHDFA MNEVLPGTGV DAETFWHSLS QIVHTLSPRN
60 70 80 90 100
RALLSKRDDL QAKIDAWHRA NRAPSDLQAY EAFLREIGYL LPEGPDFKVT
110 120 130 140 150
TSDVDPEISQ IAGPQLVVPV MNARYALNAA NARWGSLYDA LYGTDAIPET
160 170 180 190 200
AGAERGKGFN PQRGEKVIAW ARKFLDESIP LRNASWADAA RLSVKDGKLA
210 220 230 240 250
VDFDGAAADL ADPAQFTGYS GEADSPREVV LARNGLHVRI IIDRNHPIGS
260 270 280 290 300
TDRAGIADVV MEAALTTIMD CEDSVAAVDA EDKVLAYRNW LGLMKGDLEE
310 320 330 340 350
TFQKGGTTVT RKLNQDIRLT APDGSPIKLP GRSLMLVRNV GHLMTNPAIL
360 370 380 390 400
DRDGKEVPEG IMDAMFTALI ALHDIGPNGR RMNSRAGSMY VVKPKMHGPE
410 420 430 440 450
EVAFAVELFG SVEDALGMRP NTIKMGIMDE ERRTTVNLKE CIRAASERVV
460 470 480 490 500
FINTGFLDRT GDEIHTSMEA GPMIRKGDMK QSTWIAAYEN WNVDIGLLCG
510 520 530 540 550
LSGRAQIGKG MWAMPDLMAA MLDQKIAHPK AGANTAWVPS PTAATLHATH
560 570 580 590 600
YHQVDVKAVQ EGLKSRTRAK LGDILSIPVA VRPNWSPEDI RQELDNNAQG
610 620 630 640 650
ILGYVVRWID QGVGCSKVPD INNVGLMEDR ATLRISSQHI ANWLHHGVVT
660 670 680 690 700
PEQVMETMKR MAEVVDSQNA GDPDYEPIAP NFEDSIAFQA ACDLVFKGRE
710 720 730
QPNGYTEPVL HARRLQKKAQ DRKGAAADSS RG
Length:732
Mass (Da):80,279
Last modified:August 22, 2006 - v1
Checksum:i7B62E9807F370B74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA Translation: ABG65282.1
RefSeqiWP_011583223.1, NC_008254.1

Genome annotation databases

EnsemblBacteriaiABG65282; ABG65282; Meso_3915
KEGGimes:Meso_3915

Similar proteinsi

Entry informationi

Entry nameiMASZ_CHESB
AccessioniPrimary (citable) accession number: Q11BE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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