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Q11BD3

- TRMB_CHESB

UniProt

Q11BD3 - TRMB_CHESB

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631S-adenosyl-L-methionineUniRule annotation
    Binding sitei88 – 881S-adenosyl-L-methionineUniRule annotation
    Binding sitei115 – 1151S-adenosyl-L-methionineUniRule annotation
    Active sitei137 – 1371By similarity
    Binding sitei137 – 1371S-adenosyl-L-methionineUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Binding sitei173 – 1731SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCSP266779:GI09-3990-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Meso_3925
    OrganismiChelativorans sp. (strain BNC1)
    Taxonomic identifieri266779 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
    ProteomesiUP000001820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232tRNA (guanine-N(7)-)-methyltransferasePRO_0000288177Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266779.Meso_3925.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11BD3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni211 – 2144Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiRAFYGRR.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q11BD3-1 [UniParc]FASTAAdd to Basket

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    MAERHPERST EAFFGRRRGK RLRSQQTAAV EKLLPRLKLD LSSPAPAALD    50
    SLFGKPLREI RLEIGFGGGE HLLNEIRRHP DVGFIGVEPF VNGMAKLVAA 100
    LEGEAPPNLR LYDDDATKLL DWLPDSAISR IDLFYPDPWP KKRHWKRRFV 150
    NKANLDRFAR VLCVDGQFRF ASDIEGYVNW TLLACRAHPD FRWVAKSAED 200
    WRHPYEGWPG TRYEAKAMRE GRHPAYLTFV RV 232
    Length:232
    Mass (Da):26,790
    Last modified:August 22, 2006 - v1
    Checksum:i0C0EC14CDE0C4E98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000390 Genomic DNA. Translation: ABG65292.1.
    RefSeqiWP_011583233.1. NC_008254.1.
    YP_676457.1. NC_008254.1.

    Genome annotation databases

    EnsemblBacteriaiABG65292; ABG65292; Meso_3925.
    GeneIDi4180406.
    KEGGimes:Meso_3925.
    PATRICi21348240. VBICheSp72577_4718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000390 Genomic DNA. Translation: ABG65292.1 .
    RefSeqi WP_011583233.1. NC_008254.1.
    YP_676457.1. NC_008254.1.

    3D structure databases

    ProteinModelPortali Q11BD3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266779.Meso_3925.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG65292 ; ABG65292 ; Meso_3925 .
    GeneIDi 4180406.
    KEGGi mes:Meso_3925.
    PATRICi 21348240. VBICheSp72577_4718.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi RAFYGRR.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CSP266779:GI09-3990-MONOMER.

    Family and domain databases

    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BNC1.

    Entry informationi

    Entry nameiTRMB_CHESB
    AccessioniPrimary (citable) accession number: Q11BD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3