ID   CYSH_MESSB              Reviewed;         245 AA.
AC   Q11B66;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Phosphoadenosine phosphosulfate reductase;
DE            EC=1.8.4.8;
DE   AltName: Full=PAPS reductase, thioredoxin dependent;
DE   AltName: Full=PAdoPS reductase;
DE   AltName: Full=3'-phosphoadenylylsulfate reductase;
DE   AltName: Full=PAPS sulfotransferase;
GN   Name=cysH; OrderedLocusNames=Meso_3992;
OS   Mesorhizobium sp. (strain BNC1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Richardson P.;
RT   "Complete sequence of chromosome of Mesorhizobium sp. BNC1.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of activated sulfate into sulfite (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite +
CC       thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
CC   -!- PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite
CC       from sulfate: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.
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DR   EMBL; CP000390; ABG65359.1; -; Genomic_DNA.
DR   RefSeq; YP_676524.1; -.
DR   GeneID; 4180454; -.
DR   GenomeReviews; CP000390_GR; Meso_3992.
DR   KEGG; mes:Meso_3992; -.
DR   NMPDR; fig|266779.1.peg.3068; -.
DR   HOGENOM; Q11B66; -.
DR   OMA; Q11B66; FEETLAY.
DR   BioCyc; MSP266779:MESO_3992-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004604; F:phosphoadenylyl-sulfate reductase (thioredo...; IEA:HAMAP.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0019379; P:sulfate assimilation, phosphoadenylyl sulfa...; IEA:HAMAP.
DR   HAMAP; MF_00063; -; 1.
DR   InterPro; IPR004511; PAdo_PSO4_Rdtase_CysH.
DR   InterPro; IPR002500; PAPS_reduct.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   Pfam; PF01507; PAPS_reduct; 1.
DR   TIGRFAMs; TIGR00434; cysH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Oxidoreductase.
FT   CHAIN         1    245       Phosphoadenosine phosphosulfate
FT                                reductase.
FT                                /FTId=PRO_1000075073.
SQ   SEQUENCE   245 AA;  26754 MW;  232F615C6FA344DB CRC64;
     MAAKPKPLDA EIEALELDAR YGHLAAEAIV ELAVNRFRDE GGIATVSSFG ADSAVLLHMV
     ASVDKSLPVL FLDTGQHFGE TIEYRDQLAS DLGLSNLVVV HPKSEMLSAR DPGNDLHKSD
     SDLCCEIRKV EPMARAVEPY SAWFTGRKRH QAESRAQMPV FEAVGPRIRI NPLARWTTAD
     QAAYMRANDL RENPLVAYGY LSIGCFPCTQ PVKPGEDQRS GRWAGLAKTE CGIHLPGLEA
     LTNAA
//