Reviewed, UniProtKB/Swiss-Prot Q11B66 (CYSH_MESSB)

Names and origin

Protein names

Recommended name:
    Phosphoadenosine phosphosulfate reductase
    EC=1.8.4.8
Alternative name(s):
    PAPS reductase, thioredoxin dependent
    PAdoPS reductase
    3'-phosphoadenylylsulfate reductase
    PAPS sulfotransferase

Gene names

Name:	cysH
Ordered Locus Names:	Meso_3992

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reduction of activated sulfate into sulfite By similarity.
Catalytic activity	Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the PAPS reductase family. CysH subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphoadenylyl-sulfate reductase (thioredoxin) activity Inferred from electronic annotation. Source: HAMAP transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Phosphoadenosine phosphosulfate reductase		PRO_1000075073

Sequences

	Sequence		Length	Mass (Da)
	Q11B66-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 232F615C6FA344DB	FASTA	245	26,754
	10 20 30 40 50 60 MAAKPKPLDA EIEALELDAR YGHLAAEAIV ELAVNRFRDE GGIATVSSFG ADSAVLLHMV 70 80 90 100 110 120 ASVDKSLPVL FLDTGQHFGE TIEYRDQLAS DLGLSNLVVV HPKSEMLSAR DPGNDLHKSD 130 140 150 160 170 180 SDLCCEIRKV EPMARAVEPY SAWFTGRKRH QAESRAQMPV FEAVGPRIRI NPLARWTTAD 190 200 210 220 230 240 QAAYMRANDL RENPLVAYGY LSIGCFPCTQ PVKPGEDQRS GRWAGLAKTE CGIHLPGLEA LTNAA

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000390 Genomic DNA. Translation: ABG65359.1.
RefSeq	YP_676524.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4180454.
GenomeReviews	Gene locus Meso_3992 in contig CP000390_GR.
KEGG	mes:Meso_3992.
NMPDR	fig|266779.1.peg.3068.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q11B66.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_3992-MON.
Family and domain databases
HAMAP	MF_00063. [Tree]
InterPro	IPR004511. CysH. IPR002500. PAPS_reduct. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01507. PAPS_reduct. 1 hit. [Graphical view]
TIGRFAMs	TIGR00434. cysH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSH_MESSB

Accession

Primary (citable) accession number: Q11B66

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 22, 2006
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)