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Q11AZ6 (Q11AZ6_MESSB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dut HAMAP MF_00116
Ordered Locus Names:Meso_4062
OrganismMesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]
Taxonomic identifier266779 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181

Cofactor

Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region80 – 823Substrate binding By similarity HAMAP MF_00116
Region97 – 993Substrate binding By similarity HAMAP MF_00116

Sites

Binding site931Substrate By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
Q11AZ6 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 64AF9D6CB9A2D1BA

FASTA16116,933
        10         20         30         40         50         60 
MTSSPVSMPV IGPAIGVVRL PHAKDLPLPS YESAGAAGMD LRAAVAEDRR IILLPGRRAL 

        70         80         90        100        110        120 
VPTGFILEIP EGFEGQVRPR SGLALRNGIT CLNTPGTIDS DYRGEVQVLL VNLGEEDFAV 

       130        140        150        160 
TRGMRIAQLV IAPITRATIE ERASAGETRR GSGGFGSTGT V

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References

[1]"Complete sequence of chromosome of Mesorhizobium sp. BNC1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BNC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000390 Genomic DNA. Translation: ABG65429.1.
RefSeqYP_676594.1. NC_008254.1.

3D structure databases

ProteinModelPortalQ11AZ6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ11AZ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4181635.
GenomeReviewsGene locus Meso_4062 in contig CP000390_GR.
KEGGmes:Meso_4062.
NMPDRfig|266779.1.peg.3000.
PATRIC21348526. VBICheSp72577_4859.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0756.
HOGENOMHBG436079.
OMALDLRACI.
PhylomeDBQ11AZ6.
ProtClustDBPRK00601.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ11AZ6_MESSB
AccessionPrimary (citable) accession number: Q11AZ6
Entry history
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info