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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi266 – 2661Manganese 2UniRule annotation
Metal bindingi271 – 2711Manganese 1UniRule annotation
Metal bindingi271 – 2711Manganese 2UniRule annotation
Active sitei278 – 2781UniRule annotation
Metal bindingi290 – 2901Manganese 2UniRule annotation
Metal bindingi349 – 3491Manganese 1UniRule annotation
Metal bindingi351 – 3511Manganese 1UniRule annotation
Metal bindingi351 – 3511Manganese 2UniRule annotation
Active sitei353 – 3531UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciTERY203124:GJDR-69-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
Short name:
LAPUniRule annotation
Leucyl aminopeptidaseUniRule annotation
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:Tery_0069
OrganismiTrichodesmium erythraeum (strain IMS101)
Taxonomic identifieri203124 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium
Proteomesi
  • UP000008878 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable cytosol aminopeptidasePRO_1000019996Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203124.Tery_0069.

Structurei

3D structure databases

ProteinModelPortaliQ11A96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ6. Bacteria.
COG0260. LUCA.
HOGENOMiHOG000243129.
KOiK01255.
OMAiMISGRAM.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PANTHERiPTHR11963. PTHR11963. 1 hit.
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11A96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIKVGNIPQ LKWAGDALAI GLFEDAIKLT EDAIELTEEM AELDEMLSGT
60 70 80 90 100
LSELIKETEF KGKANSSVST RVGIKTSIRK IIVVGLGKLE KFKLDSLRQA
110 120 130 140 150
AATCGRLAKK ERCKTLGISL PMCQDADSTA IAITEGIELA LHQDNRFKSE
160 170 180 190 200
PENLGPDLEK VELIGLAASD EAIAHARKIC SGVIFARELV AAPANSCTPI
210 220 230 240 250
TMAETAQTLA KEFGLTLEIL EKEDCEKLGM GAFLGVAQGS DLPPKFIHVT
260 270 280 290 300
YKPEVTPRRK LAIVGKGLTF DSGGLNLKVS GSGIEMMKID MGGAGTTFGT
310 320 330 340 350
IKAIAQLKPD VEVHFISAVT ENMVSGHAIH PGDFLTASNG KIIEVNNTDA
360 370 380 390 400
EGRLTLADAL VFAEKLGVDA IIDLATLTGA CVVALGNDIA GLWSPNDNLA
410 420 430 440 450
AEITAAAEKA GEKMWRMPLE EKYFEGLKAM HADMKNTGPR PGGAITAALF
460 470 480 490
LKQFVKNTPW AHLDIAGPVW VDTENGYNNQ GATGYGVRTL VNWILS
Length:496
Mass (Da):52,944
Last modified:August 22, 2006 - v1
Checksum:i3F1FEE86724CB560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000393 Genomic DNA. Translation: ABG49578.1.
RefSeqiWP_011609979.1. NC_008312.1.

Genome annotation databases

EnsemblBacteriaiABG49578; ABG49578; Tery_0069.
KEGGiter:Tery_0069.
PATRICi23983274. VBITriEry99848_0085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000393 Genomic DNA. Translation: ABG49578.1.
RefSeqiWP_011609979.1. NC_008312.1.

3D structure databases

ProteinModelPortaliQ11A96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203124.Tery_0069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG49578; ABG49578; Tery_0069.
KEGGiter:Tery_0069.
PATRICi23983274. VBITriEry99848_0085.

Phylogenomic databases

eggNOGiENOG4105BZ6. Bacteria.
COG0260. LUCA.
HOGENOMiHOG000243129.
KOiK01255.
OMAiMISGRAM.
OrthoDBiEOG6FV8B3.

Enzyme and pathway databases

BioCyciTERY203124:GJDR-69-MONOMER.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PANTHERiPTHR11963. PTHR11963. 1 hit.
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IMS101.

Entry informationi

Entry nameiAMPA_TRIEI
AccessioniPrimary (citable) accession number: Q11A96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.