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Q119Z5

- SYE_TRIEI

UniProt

Q119Z5 - SYE_TRIEI

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).By similarity

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei251 – 2511ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-tRNA ligase activity Source: UniProtKB-EC
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTERY203124:GJDR-190-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligase (EC:6.1.1.17)
    Alternative name(s):
    Glutamyl-tRNA synthetase
    Short name:
    GluRS
    Gene namesi
    Name:gltX
    Ordered Locus Names:Tery_0188
    OrganismiTrichodesmium erythraeum (strain IMS101)
    Taxonomic identifieri203124 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium
    ProteomesiUP000008878: Chromosome

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane Curated; Multi-pass membrane protein Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 881881Glutamate--tRNA ligasePRO_0000367797Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi203124.Tery_0188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ119Z5.
    SMRiQ119Z5. Positions 2-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei809 – 82921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei832 – 85221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 480480Glutamyl-tRNA synthetaseAdd
    BLAST
    Regioni481 – 881401UnknownAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi9 – 1911"HIGH" regionAdd
    BLAST
    Motifi248 – 2525"KMSKS" region

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi510 – 772263Thr-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0008.
    KOiK01885.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR025564. CAAD_dom.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF14159. CAAD. 1 hit.
    PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q119Z5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVRVRLAPS PTGNLHIGTA RTAVFNWLFA RNQKGKFILR IEDTDQERSR    50
    PEYTDNILEG LSWLGLEWDE GPFYQCQRYE LYQKATQSLL DKGLAYRCYC 100
    TAAELEEMRE AQKARKEAPR YDNRHRNLTD LEKKAFEAEG RQAVIRFRID 150
    DDQIITWNDM VRGKVTWKGS DLGGDMVISR AAGGDEVGQP LYNMAVVVDD 200
    MDMEITHVIR GEDHIANTAK QILLYEALGG KIPEFGHTPL ILNKEGRKLS 250
    KRDGVTSISD FQELGFTPEA LANYMCLLGW TPPDATEEIF TLAQAGQNFS 300
    FERVNKAGAK FDWDKLDWIS SQYLHNLPVK QLTDKLIPIW QKAGYELDPE 350
    GDRSWLEQLV TLIRPSLTRL TDAVEMSELF FFPTVELNED AKTQMQNEDS 400
    VKSINSILEI INADAPLLVA DVKQTIKKVT QKVHVKKGVV MRSLRASLTG 450
    AMQGPDLIES WLLLHQKGFD ILRFKKSIGQ EIEDTKIEDT KKAETTPHKS 500
    KGEGNVLLKT TTPKSPALSK EQTQTTKPPK KGQTATPVAT TPTATDVTEN 550
    TSVGTQETQS QITTPVATTP TATDVTENTS VGTQETQSQI TTPVATTPTA 600
    TDVTENTSVE TQETQSQITT PVATTPTATD VTENTSVETQ ETQSQITTPV 650
    ATTPTATDVT ENTSVGTQET QSQITTPVAT TPTATDVTEN TSVETQETQS 700
    QITTPVATTS TATDVTENTS VETQETQSQI TTPVATTPTA TDAETREQKV 750
    ATQVETSILD DQKPVDTVTN QTVEVEQPNK IKEQFINIFF NFPDYINQLY 800
    QQYQGQLKLF GWLALVILTF TFMAVVIEAL DGIPILSIIF ELIGVIYLVW 850
    FVYRYLLKRS NRQELLDKIE NIKREIFGKP S 881
    Length:881
    Mass (Da):98,269
    Last modified:August 22, 2006 - v1
    Checksum:i1C675432E0CA07E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000393 Genomic DNA. Translation: ABG49679.1.
    RefSeqiYP_720152.1. NC_008312.1.

    Genome annotation databases

    EnsemblBacteriaiABG49679; ABG49679; Tery_0188.
    GeneIDi4242194.
    KEGGiter:Tery_0188.
    PATRICi23983588. VBITriEry99848_0240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000393 Genomic DNA. Translation: ABG49679.1 .
    RefSeqi YP_720152.1. NC_008312.1.

    3D structure databases

    ProteinModelPortali Q119Z5.
    SMRi Q119Z5. Positions 2-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203124.Tery_0188.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG49679 ; ABG49679 ; Tery_0188 .
    GeneIDi 4242194.
    KEGGi ter:Tery_0188.
    PATRICi 23983588. VBITriEry99848_0240.

    Phylogenomic databases

    eggNOGi COG0008.
    KOi K01885.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci TERY203124:GJDR-190-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR025564. CAAD_dom.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF14159. CAAD. 1 hit.
    PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IMS101.

    Entry informationi

    Entry nameiSYE_TRIEI
    AccessioniPrimary (citable) accession number: Q119Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3