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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTERY203124:G1G6S-597-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:Tery_0581
OrganismiTrichodesmium erythraeum (strain IMS101)
Taxonomic identifieri203124 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesMicrocoleaceaeTrichodesmium
Proteomesi
  • UP000008878 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000184181 – 409Tryptophan synthase beta chainAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ118P8

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi203124.Tery_0581

Structurei

3D structure databases

ProteinModelPortaliQ118P8
SMRiQ118P8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CG0 Bacteria
COG0133 LUCA
HOGENOMiHOG000161710
KOiK01696
OMAiHGMKSYF
OrthoDBiPOG091H02JY

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q118P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITPLNPTS TQQPDSLGRF GKFGGKYVPE TLMPALLQLE TACKKYSQDP
60 70 80 90 100
TFKQELQQLL RDYVGRPSPL YFAERLTAHY TKPDGTGPQI YLKREDLNHT
110 120 130 140 150
GAHKINNALG QALLAQRMGK QRIIAETGAG QHGVATATVC ARFGLKCVIY
160 170 180 190 200
MGIHDMERQA LNVFRMRLMG AEVRPVEAGT GTLKDATSEA IRDWVTNVET
210 220 230 240 250
THYILGSVAG PHPYPMMVRD FHAVIGVETR AQCLEKWNGL PDILMACVGG
260 270 280 290 300
GSNAMGLFHE FINDPSVRMI GVEAAGKGVD TNKHAATLTL GRVGVLHGAM
310 320 330 340 350
SYLLQDEEGQ IIEPHSISAG LDYPGVGPEH SFLKDSGRVE YYSVTDNEAV
360 370 380 390 400
AAFQRLSQLE GIIPALETAH AIAYLETLCP QLSGSPRIVF NCSGRGDKDV

QTVGKFLEG
Length:409
Mass (Da):44,526
Last modified:August 22, 2006 - v1
Checksum:iF76F00EA3B3B3660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000393 Genomic DNA Translation: ABG50026.1
RefSeqiWP_011610420.1, NC_008312.1

Genome annotation databases

EnsemblBacteriaiABG50026; ABG50026; Tery_0581
KEGGiter:Tery_0581

Similar proteinsi

Entry informationi

Entry nameiTRPB_TRIEI
AccessioniPrimary (citable) accession number: Q118P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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