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Protein

Ribonuclease Z

Gene

rnz

Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Zinc 1; catalyticUniRule annotation1
Metal bindingi64Zinc 1; catalyticUniRule annotation1
Active sitei66Proton acceptorUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi67Zinc 2; catalyticUniRule annotation1
Metal bindingi139Zinc 1; catalyticUniRule annotation1
Metal bindingi210Zinc 1; catalyticUniRule annotation1
Metal bindingi210Zinc 2; catalyticUniRule annotation1
Metal bindingi268Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:Tery_0641
OrganismiTrichodesmium erythraeum (strain IMS101)
Taxonomic identifieri203124 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesMicrocoleaceaeTrichodesmium
Proteomesi
  • UP000008878 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000703501 – 321Ribonuclease ZAdd BLAST321

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi203124.Tery_0641.

Structurei

3D structure databases

ProteinModelPortaliQ118J2.
SMRiQ118J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiGTQRQMM.
OrthoDBiPOG091H07TH.

Family and domain databases

CDDicd07717. RNaseZ_ZiPD-like_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiView protein in InterPro
IPR001279. Metallo-B-lactamas.
IPR036866. Metallo-hydrolase/OxRdtase.
IPR013471. RNase_Z/BN.
PfamiView protein in Pfam
PF12706. Lactamase_B_2. 2 hits.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

Q118J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQITFLGTSS GVPTRSRNVS SIALRLPQRA ELWLFDCGEG TQHQFLRSDL
60 70 80 90 100
KVSQLSRIFI THMHGDHVFG LMGLLASCGL GGNVKSVTLY GPPALEDYLQ
110 120 130 140 150
AGLRYSQTHL AYPIKVHKSK PGVIYEDDEY VVSCAYLKHR VTAFGYRVTE
160 170 180 190 200
KDRPGHFNVE KAKALGIPPG PIYRKLKQGE FVTLPDGRKI NGADLCGAPH
210 220 230 240 250
VGRKFVYCTD TVFCDGAVEL SQGADLLVHE ATFSHQDAEM AFQRLHSTST
260 270 280 290 300
MAAQVALAAG VKHLMMTHFS PRYAPGNSVL LDDLLQEARA IFPNTDMAYD
310 320
FLSYEIPRWN EVSQLLAKAR S
Length:321
Mass (Da):35,546
Last modified:August 22, 2006 - v1
Checksum:i0341A99E798DABFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000393 Genomic DNA. Translation: ABG50082.1.
RefSeqiWP_011610475.1. NC_008312.1.

Genome annotation databases

EnsemblBacteriaiABG50082; ABG50082; Tery_0641.
KEGGiter:Tery_0641.

Similar proteinsi

Entry informationi

Entry nameiRNZ_TRIEI
AccessioniPrimary (citable) accession number: Q118J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: October 25, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families