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Protein

Argininosuccinate lyase

Gene

argH

Organism
Trichodesmium erythraeum (strain IMS101)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Tery_0740Imported
OrganismiTrichodesmium erythraeum (strain IMS101)Imported
Taxonomic identifieri203124 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesMicrocoleaceaeTrichodesmium
Proteomesi
  • UP000008878 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi203124.Tery_0740.

Structurei

3D structure databases

ProteinModelPortaliQ118A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 304Lyase_1InterPro annotationAdd BLAST294
Domaini368 – 435ASL_C2InterPro annotationAdd BLAST68

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiAHHLMAY.
OrthoDBiPOG091H026A.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q118A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQDRQTWSQ RFEKALHPMI ARFNASISFD IELIEHDING SVAHTKMLAK
60 70 80 90 100
TGIISAEEGE KLLTGLEQIR QEYITGNFHI VEDAEDVHFA VEKRLIEITG
110 120 130 140 150
DVGKKLHTAR SRNDQVGTDT RLYLREKIEQ IRFLLIKFQK VILELAESNI
160 170 180 190 200
ETLIPGYTHL QRAQPLSLAH HLLAYFHKAE RDWERLGDVY RRVNISPLGC
210 220 230 240 250
GALAGTTFPI DRHYTAELLG FEKPYANSLD GVSDRDFAIE FLCAASIIMV
260 270 280 290 300
HLSRLAEEII VWSSEEFRFV TLTDVCSTGS SIMPQKKNPD VPELVRGKTG
310 320 330 340 350
RVFGHLQSML VVMKGLPLAY NKDLQEDKEG LFDSIKTVKS CLEAMTILLE
360 370 380 390 400
EGLEFNSDRL TEAVAEDFSN ATDVADYLAA RGVPFREAYN LVGKVVKTCI
410 420 430 440 450
SGGKLLKDLT IKEWKELHPV FASDIYEAIT PYQVVSARNS YGGTGFKQVK
460
TEIDVAKQKL AEK
Length:463
Mass (Da):52,195
Last modified:August 22, 2006 - v1
Checksum:iE8D72876F532CAD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000393 Genomic DNA. Translation: ABG50171.1.
RefSeqiWP_011610564.1. NC_008312.1.

Genome annotation databases

EnsemblBacteriaiABG50171; ABG50171; Tery_0740.
KEGGiter:Tery_0740.
PATRICi23984975. VBITriEry99848_0928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000393 Genomic DNA. Translation: ABG50171.1.
RefSeqiWP_011610564.1. NC_008312.1.

3D structure databases

ProteinModelPortaliQ118A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203124.Tery_0740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG50171; ABG50171; Tery_0740.
KEGGiter:Tery_0740.
PATRICi23984975. VBITriEry99848_0928.

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiAHHLMAY.
OrthoDBiPOG091H026A.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ118A3_TRIEI
AccessioniPrimary (citable) accession number: Q118A3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.