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Q116T4

- PUR9_TRIEI

UniProt

Q116T4 - PUR9_TRIEI

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Tery_1128
Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciTERY203124:GJDR-1135-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Tery_1128
OrganismiTrichodesmium erythraeum (strain IMS101)
Taxonomic identifieri203124 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium
ProteomesiUP000008878: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018984Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203124.Tery_1128.

Structurei

3D structure databases

ProteinModelPortaliQ116T4.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q116T4-1 [UniParc]FASTAAdd to Basket

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MKRLALLSTS DKTGLIDLAK SLVTEFDYEI ISSGGTAKTL KDAGIYVTKV    50
SDYTGFPEIL GGRVKTLHPR IHGGILARKD LPQDVEELNA NNIRPIDLVV 100
VNLYPFEETI SKPEVTLAEA IEKIDIGGPA MLRASAKNFA HLTVLCNHFQ 150
YNSYLEELRK NAGEVSLEFR QKCALAGFKH TATYDQAIAT YLQEQQTTSE 200
SEKSEKEIFF LSGKKIKTLR YGENPHQYAT WYQRGINASG WGASKIIQGK 250
ELSYNNLVDL EAARRIIIEF SDAPTVAILK HTNPCGVAVD ETILAAYERA 300
FAGDSVSAFG GIVALNKSID AATAKAMTKT FLECVVAPGC EPEAEKIFKS 350
KSKLRVLISP YFKQSEPETI KVISGGFLVQ DTDDTIDNYS DWKIVTEKQP 400
TTEQIEELMF AWKVVKHVKS NAIVVTKNRA TVGIGAGQMN RVGAVKIALE 450
QAGEKAIGGV LASDAFFPFD DSVKTAAAAG VTAIIQPGGS LKDKDSIAAA 500
NELGLIMILT GIRHFLH 517
Length:517
Mass (Da):56,371
Last modified:August 22, 2006 - v1
Checksum:i30B1AB24FF63B165
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000393 Genomic DNA. Translation: ABG50490.1.
RefSeqiYP_720963.1. NC_008312.1.

Genome annotation databases

EnsemblBacteriaiABG50490; ABG50490; Tery_1128.
GeneIDi4242860.
KEGGiter:Tery_1128.
PATRICi23985949. VBITriEry99848_1413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000393 Genomic DNA. Translation: ABG50490.1 .
RefSeqi YP_720963.1. NC_008312.1.

3D structure databases

ProteinModelPortali Q116T4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203124.Tery_1128.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG50490 ; ABG50490 ; Tery_1128 .
GeneIDi 4242860.
KEGGi ter:Tery_1128.
PATRICi 23985949. VBITriEry99848_1413.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci TERY203124:GJDR-1135-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IMS101.

Entry informationi

Entry nameiPUR9_TRIEI
AccessioniPrimary (citable) accession number: Q116T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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