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Q116P1

- DAPF_TRIEI

UniProt

Q116P1 - DAPF_TRIEI

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Protein
Diaminopimelate epimerase
Gene
dapF, Tery_1173
Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131Substrate By similarity
Binding sitei47 – 471Substrate By similarity
Binding sitei66 – 661Substrate By similarity
Active sitei75 – 751Proton donor/acceptor By similarity
Binding sitei162 – 1621Substrate By similarity
Sitei164 – 1641Important for catalytic activity By similarity
Binding sitei195 – 1951Substrate By similarity
Sitei213 – 2131Important for catalytic activity By similarity
Active sitei222 – 2221Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciTERY203124:GJDR-1180-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:Tery_1173
OrganismiTrichodesmium erythraeum (strain IMS101)
Taxonomic identifieri203124 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium
ProteomesiUP000008878: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Diaminopimelate epimeraseUniRule annotation
PRO_1000011978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 222UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi203124.Tery_1173.

Structurei

3D structure databases

ProteinModelPortaliQ116P1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 112Substrate binding By similarity
Regioni75 – 773Substrate binding By similarity
Regioni213 – 2142Substrate binding By similarity
Regioni223 – 2242Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiLIVEPPY.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q116P1-1 [UniParc]FASTAAdd to Basket

« Hide

MTKSFTKYHG LGNDFILIDN RHQLQPILTP EQAIELCDRN FGIGADGVIF    50
ALPGVKQTDY TMRIFNSDGS EPEMCGNGIR CLAKFIAELE NNNKTKYNIH 100
TGAGIIVPEL QGDGQVTVDM GQPRLLASEI PTTLANADDK VVDQLLEVGG 150
KSWFVTCVSM GNPHCITFVE DVTAIDLAKI GPKFEHNPVF PERTNTEFIQ 200
VISPKYVKMR VWERGAGATL ACGTGACASV VAGVLTQNNE RLVTVELPGG 250
CLEIEWSTID QKIYMTGPAE KVFTGIIA 278
Length:278
Mass (Da):30,279
Last modified:August 22, 2006 - v1
Checksum:i77B39B893B94FCCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000393 Genomic DNA. Translation: ABG50533.1.
RefSeqiWP_011610919.1. NC_008312.1.
YP_721006.1. NC_008312.1.

Genome annotation databases

EnsemblBacteriaiABG50533; ABG50533; Tery_1173.
GeneIDi4244057.
KEGGiter:Tery_1173.
PATRICi23986041. VBITriEry99848_1459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000393 Genomic DNA. Translation: ABG50533.1 .
RefSeqi WP_011610919.1. NC_008312.1.
YP_721006.1. NC_008312.1.

3D structure databases

ProteinModelPortali Q116P1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203124.Tery_1173.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG50533 ; ABG50533 ; Tery_1173 .
GeneIDi 4244057.
KEGGi ter:Tery_1173.
PATRICi 23986041. VBITriEry99848_1459.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi LIVEPPY.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci TERY203124:GJDR-1180-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IMS101.

Entry informationi

Entry nameiDAPF_TRIEI
AccessioniPrimary (citable) accession number: Q116P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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