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Q114V5 (SYL_TRIEI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Tery_1704
OrganismTrichodesmium erythraeum (strain IMS101) [Complete proteome] [HAMAP]
Taxonomic identifier203124 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium

Protein attributes

Sequence length929 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 929929Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009459

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif614 – 6185"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6171ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q114V5 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: CBEA3835F051A92A

FASTA929105,715
        10         20         30         40         50         60 
MDSKYNPVSI EQKWQKNWAE QNQDQTPINN NQPKFYALSM FPYPSGNLHM GHVRNYTITD 

        70         80         90        100        110        120 
VIARLKRMQG YRVLHPMGWD AFGLPAENAA IDRGIPPAKW TLENIAQMKE QLRRLGFSID 

       130        140        150        160        170        180 
WDKEVATCTP EYYRWTQWIF LQFFQAGLAY QKESAVNWDP IDQTVLANEQ VDGEGRSWRS 

       190        200        210        220        230        240 
GAKVERKMLR QWFFKITDYA EQLLNDLDKL PGWPERVKLM QANWIGKSVG AYLEFPIVGM 

       250        260        270        280        290        300 
DQKIGVFTTR PDTVYGVSYV VLAPEHPLTA KVTTPEQQIT VETFIKEVAA ESELERTAED 

       310        320        330        340        350        360 
KPKRGVPTGG KAINPFNNQE VPIWIADYVL YEYGTGAVMG VPAHDVRDFQ FAKQYNLPIK 

       370        380        390        400        410        420 
TVIVPDDSND DHKLTEAYTD VGVMVNSGPF NGEKSTVAKK AIIELAEDEG YGKGRVQYRL 

       430        440        450        460        470        480 
RDWLISRQRY WGAPIPIIHC PKCGAVPVPD EDLPVKLPES VEFSGRGPSP LAKLEDWVNV 

       490        500        510        520        530        540 
SCPSCGTPAK RETDTMDTFI DSSWYYLRYP DATNEEQVFD SKIVNDWLPV DQYVGGIEHA 

       550        560        570        580        590        600 
ILHLLYSRFF TKVLRDRGLC DFDEPFQNLL TQGMVQGVTY KNPVTGKYIP FADVNPQEPK 

       610        620        630        640        650        660 
DPKTGDKLEV FFEKMSKSKY NGVDPMDVMA TYGADTARMF ILFKAPPEKD LEWDDADVQG 

       670        680        690        700        710        720 
QFRFLNRVWS MVMEFLANHS FSELKAKHHG ITQADLKDLG WSRYLITEIT KNISAFKLRN 

       730        740        750        760        770        780 
VVKVYPVEDV LVAIEAKFNY SETQQETKDD LQKVLTWIKS RFGGELTKAE KDVRRAVHNA 

       790        800        810        820        830        840 
IKEVTEDLDG DYQFNTAVSE MMKLSNALGD ASCKDSPIYA EALETLLLLL APFAPHITEE 

       850        860        870        880        890        900 
LWQIAGNFGS VHTHAWPKFD PEALVVDEIT LVIQIKGKTR GTIQVPAQAD KETLEKLARE 

       910        920 
SDIAQRHLAG KEIKKVIVVP RKLVNFVVI 

« Hide

References

[1]"Complete sequence of Trichodesmium erythraeum IMS101."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IMS101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000393 Genomic DNA. Translation: ABG50969.1.
RefSeqYP_721442.1. NC_008312.1.

3D structure databases

ProteinModelPortalQ114V5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203124.Tery_1704.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG50969; ABG50969; Tery_1704.
GeneID4244089.
KEGGter:Tery_1704.
PATRIC23987455. VBITriEry99848_2163.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycTERY203124:GJDR-1715-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 2 hits.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_TRIEI
AccessionPrimary (citable) accession number: Q114V5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries