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Q114V5

- SYL_TRIEI

UniProt

Q114V5 - SYL_TRIEI

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei617 – 6171ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTERY203124:GJDR-1715-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Tery_1704
    OrganismiTrichodesmium erythraeum (strain IMS101)
    Taxonomic identifieri203124 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium
    ProteomesiUP000008878: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 929929Leucine--tRNA ligasePRO_1000009459Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203124.Tery_1704.

    Structurei

    3D structure databases

    ProteinModelPortaliQ114V5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi614 – 6185"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 2 hits.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q114V5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSKYNPVSI EQKWQKNWAE QNQDQTPINN NQPKFYALSM FPYPSGNLHM    50
    GHVRNYTITD VIARLKRMQG YRVLHPMGWD AFGLPAENAA IDRGIPPAKW 100
    TLENIAQMKE QLRRLGFSID WDKEVATCTP EYYRWTQWIF LQFFQAGLAY 150
    QKESAVNWDP IDQTVLANEQ VDGEGRSWRS GAKVERKMLR QWFFKITDYA 200
    EQLLNDLDKL PGWPERVKLM QANWIGKSVG AYLEFPIVGM DQKIGVFTTR 250
    PDTVYGVSYV VLAPEHPLTA KVTTPEQQIT VETFIKEVAA ESELERTAED 300
    KPKRGVPTGG KAINPFNNQE VPIWIADYVL YEYGTGAVMG VPAHDVRDFQ 350
    FAKQYNLPIK TVIVPDDSND DHKLTEAYTD VGVMVNSGPF NGEKSTVAKK 400
    AIIELAEDEG YGKGRVQYRL RDWLISRQRY WGAPIPIIHC PKCGAVPVPD 450
    EDLPVKLPES VEFSGRGPSP LAKLEDWVNV SCPSCGTPAK RETDTMDTFI 500
    DSSWYYLRYP DATNEEQVFD SKIVNDWLPV DQYVGGIEHA ILHLLYSRFF 550
    TKVLRDRGLC DFDEPFQNLL TQGMVQGVTY KNPVTGKYIP FADVNPQEPK 600
    DPKTGDKLEV FFEKMSKSKY NGVDPMDVMA TYGADTARMF ILFKAPPEKD 650
    LEWDDADVQG QFRFLNRVWS MVMEFLANHS FSELKAKHHG ITQADLKDLG 700
    WSRYLITEIT KNISAFKLRN VVKVYPVEDV LVAIEAKFNY SETQQETKDD 750
    LQKVLTWIKS RFGGELTKAE KDVRRAVHNA IKEVTEDLDG DYQFNTAVSE 800
    MMKLSNALGD ASCKDSPIYA EALETLLLLL APFAPHITEE LWQIAGNFGS 850
    VHTHAWPKFD PEALVVDEIT LVIQIKGKTR GTIQVPAQAD KETLEKLARE 900
    SDIAQRHLAG KEIKKVIVVP RKLVNFVVI 929
    Length:929
    Mass (Da):105,715
    Last modified:August 22, 2006 - v1
    Checksum:iCBEA3835F051A92A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000393 Genomic DNA. Translation: ABG50969.1.
    RefSeqiYP_721442.1. NC_008312.1.

    Genome annotation databases

    EnsemblBacteriaiABG50969; ABG50969; Tery_1704.
    GeneIDi4244089.
    KEGGiter:Tery_1704.
    PATRICi23987455. VBITriEry99848_2163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000393 Genomic DNA. Translation: ABG50969.1 .
    RefSeqi YP_721442.1. NC_008312.1.

    3D structure databases

    ProteinModelPortali Q114V5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203124.Tery_1704.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG50969 ; ABG50969 ; Tery_1704 .
    GeneIDi 4244089.
    KEGGi ter:Tery_1704.
    PATRICi 23987455. VBITriEry99848_2163.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TERY203124:GJDR-1715-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 2 hits.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IMS101.

    Entry informationi

    Entry nameiSYL_TRIEI
    AccessioniPrimary (citable) accession number: Q114V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3