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Protein

Poly [ADP-ribose] polymerase 2

Gene

PARP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 140Sequence analysisAdd BLAST140

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Glycosyltransferase, Transferase
LigandNAD

Enzyme and pathway databases

ReactomeiR-ATH-5685939 HDR through MMEJ (alt-NHEJ)
R-ATH-5696394 DNA Damage Recognition in GG-NER
R-ATH-5696395 Formation of Incision Complex in GG-NER
R-ATH-5696400 Dual Incision in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 2 (EC:2.4.2.30)
Short name:
PARP-2
Alternative name(s):
NAD(+) ADP-ribosyltransferase 2
Short name:
ADPRT-2
Poly[ADP-ribose] synthase 2
Gene namesi
Name:PARP2
Synonyms:APP
Ordered Locus Names:At4g02390
ORF Names:T14P8.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G02390
TAIRilocus:2005523 AT4G02390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113321 – 637Poly [ADP-ribose] polymerase 2Add BLAST637

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDbiQ11207
PRIDEiQ11207

PTM databases

iPTMnetiQ11207

Expressioni

Inductioni

By ionising radiation (IR)-induced DNA damage, by dehydration and after cadmium exposure.1 Publication

Gene expression databases

ExpressionAtlasiQ11207 baseline and differential
GenevisibleiQ11207 AT

Interactioni

Protein-protein interaction databases

BioGridi13340, 6 interactors
STRINGi3702.AT4G02390.1

Structurei

3D structure databases

ProteinModelPortaliQ11207
SMRiQ11207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 36SAP 1PROSITE-ProRule annotationAdd BLAST35
Domaini69 – 103SAP 2PROSITE-ProRule annotationAdd BLAST35
Domaini286 – 404PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST119
Domaini412 – 637PARP catalyticPROSITE-ProRule annotationAdd BLAST226

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 62Nuclear localization signalSequence analysisAdd BLAST22

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
HOGENOMiHOG000173055
InParanoidiQ11207
KOiK10798
OMAiIPHVFGR
OrthoDBiEOG09360465
PhylomeDBiQ11207

Family and domain databases

Gene3Di1.10.720.30, 2 hits
1.20.142.10, 1 hit
2.20.140.10, 1 hit
InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR036930 WGR_dom_sf
IPR008893 WGR_domain
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PF02877 PARP_reg, 1 hit
PF02037 SAP, 2 hits
PF05406 WGR, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 2 hits
SM00773 WGR, 1 hit
SUPFAMiSSF142921 SSF142921, 1 hit
SSF47587 SSF47587, 1 hit
SSF68906 SSF68906, 2 hits
PROSITEiView protein in PROSITE
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit
PS50800 SAP, 2 hits

Sequencei

Sequence statusi: Complete.

Q11207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKLKVDEL RLKLAERGLS TTGVKAVLVE RLEEAIAEDT KKEESKSKRK
60 70 80 90 100
RNSSNDTYES NKLIAIGEFR GMIVKELREE AIKRGLDTTG TKKDLLERLC
110 120 130 140 150
NDANNVSNAP VKSSNGTDEA EDDNNGFEEE KKEEKIVTAT KKGAAVLDQW
160 170 180 190 200
IPDEIKSQYH VLQRGDDVYD AILNQTNVRD NNNKFFVLQV LESDSKKTYM
210 220 230 240 250
VYTRWGRVGV KGQSKLDGPY DSWDRAIEIF TNKFNDKTKN YWSDRKEFIP
260 270 280 290 300
HPKSYTWLEM DYGKEENDSP VNNDIPSSSS EVKPEQSKLD TRVAKFISLI
310 320 330 340 350
CNVSMMAQHM MEIGYNANKL PLGKISKSTI SKGYEVLKRI SEVIDRYDRT
360 370 380 390 400
RLEELSGEFY TVIPHDFGFK KMSQFVIDTP QKLKQKIEMV EALGEIELAT
410 420 430 440 450
KLLSVDPGLQ DDPLYYHYQQ LNCGLTPVGN DSEEFSMVAN YMENTHAKTH
460 470 480 490 500
SGYTVEIAQL FRASRAVEAD RFQQFSSSKN RMLLWHGSRL TNWAGILSQG
510 520 530 540 550
LRIAPPEAPV TGYMFGKGVY FADMFSKSAN YCYANTGAND GVLLLCEVAL
560 570 580 590 600
GDMNELLYSD YNADNLPPGK LSTKGVGKTA PNPSEAQTLE DGVVVPLGKP
610 620 630
VERSCSKGML LYNEYIVYNV EQIKMRYVIQ VKFNYKH
Length:637
Mass (Da):72,176
Last modified:October 1, 1996 - v1
Checksum:i527A8F464605D127
GO

Sequence cautioni

The sequence AAC19283 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80732 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48243 mRNA Translation: CAA88288.1
AF069298 Genomic DNA Translation: AAC19283.1 Sequence problems.
AL161494 Genomic DNA Translation: CAB80732.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82163.1
PIRiT01311
RefSeqiNP_001329308.1, NM_001340373.1
NP_192148.2, NM_116472.4
UniGeneiAt.92

Genome annotation databases

EnsemblPlantsiAT4G02390.1; AT4G02390.1; AT4G02390
GeneIDi828049
GrameneiAT4G02390.1; AT4G02390.1; AT4G02390
KEGGiath:AT4G02390

Similar proteinsi

Entry informationi

Entry nameiPARP2_ARATH
AccessioniPrimary (citable) accession number: Q11207
Secondary accession number(s): O81294
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health