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Protein

Poly [ADP-ribose] polymerase 2

Gene

PARP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 140Sequence analysisAdd BLAST140

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

DNA-binding, NAD

Enzyme and pathway databases

BioCyciARA:AT4G02390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 2 (EC:2.4.2.30)
Short name:
PARP-2
Alternative name(s):
NAD(+) ADP-ribosyltransferase 2
Short name:
ADPRT-2
Poly[ADP-ribose] synthase 2
Gene namesi
Name:PARP2
Synonyms:APP
Ordered Locus Names:At4g02390
ORF Names:T14P8.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G02390.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113321 – 637Poly [ADP-ribose] polymerase 2Add BLAST637

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDbiQ11207.
PRIDEiQ11207.

PTM databases

iPTMnetiQ11207.

Expressioni

Inductioni

By ionising radiation (IR)-induced DNA damage, by dehydration and after cadmium exposure.1 Publication

Gene expression databases

GenevisibleiQ11207. AT.

Interactioni

Protein-protein interaction databases

BioGridi13340. 4 interactors.
STRINGi3702.AT4G02390.1.

Structurei

3D structure databases

ProteinModelPortaliQ11207.
SMRiQ11207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 36SAP 1PROSITE-ProRule annotationAdd BLAST35
Domaini69 – 103SAP 2PROSITE-ProRule annotationAdd BLAST35
Domaini286 – 404PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST119
Domaini412 – 637PARP catalyticPROSITE-ProRule annotationAdd BLAST226

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 62Nuclear localization signalSequence analysisAdd BLAST22

Sequence similaritiesi

Contains 1 PARP alpha-helical domain.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 2 SAP domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1037. Eukaryota.
ENOG410XP18. LUCA.
HOGENOMiHOG000173055.
InParanoidiQ11207.
KOiK10798.
OMAiACSGDLN.
OrthoDBiEOG09360465.
PhylomeDBiQ11207.

Family and domain databases

Gene3Di1.10.720.30. 2 hits.
1.20.142.10. 1 hit.
2.20.140.10. 1 hit.
3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004102. Poly(ADP-ribose)pol_reg_dom.
IPR003034. SAP_dom.
IPR008893. WGR_domain.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF02877. PARP_reg. 1 hit.
PF02037. SAP. 2 hits.
PF05406. WGR. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 2 hits.
SM00773. WGR. 1 hit.
[Graphical view]
SUPFAMiSSF142921. SSF142921. 1 hit.
SSF47587. SSF47587. 1 hit.
PROSITEiPS51060. PARP_ALPHA_HD. 1 hit.
PS51059. PARP_CATALYTIC. 1 hit.
PS50800. SAP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKLKVDEL RLKLAERGLS TTGVKAVLVE RLEEAIAEDT KKEESKSKRK
60 70 80 90 100
RNSSNDTYES NKLIAIGEFR GMIVKELREE AIKRGLDTTG TKKDLLERLC
110 120 130 140 150
NDANNVSNAP VKSSNGTDEA EDDNNGFEEE KKEEKIVTAT KKGAAVLDQW
160 170 180 190 200
IPDEIKSQYH VLQRGDDVYD AILNQTNVRD NNNKFFVLQV LESDSKKTYM
210 220 230 240 250
VYTRWGRVGV KGQSKLDGPY DSWDRAIEIF TNKFNDKTKN YWSDRKEFIP
260 270 280 290 300
HPKSYTWLEM DYGKEENDSP VNNDIPSSSS EVKPEQSKLD TRVAKFISLI
310 320 330 340 350
CNVSMMAQHM MEIGYNANKL PLGKISKSTI SKGYEVLKRI SEVIDRYDRT
360 370 380 390 400
RLEELSGEFY TVIPHDFGFK KMSQFVIDTP QKLKQKIEMV EALGEIELAT
410 420 430 440 450
KLLSVDPGLQ DDPLYYHYQQ LNCGLTPVGN DSEEFSMVAN YMENTHAKTH
460 470 480 490 500
SGYTVEIAQL FRASRAVEAD RFQQFSSSKN RMLLWHGSRL TNWAGILSQG
510 520 530 540 550
LRIAPPEAPV TGYMFGKGVY FADMFSKSAN YCYANTGAND GVLLLCEVAL
560 570 580 590 600
GDMNELLYSD YNADNLPPGK LSTKGVGKTA PNPSEAQTLE DGVVVPLGKP
610 620 630
VERSCSKGML LYNEYIVYNV EQIKMRYVIQ VKFNYKH
Length:637
Mass (Da):72,176
Last modified:October 1, 1996 - v1
Checksum:i527A8F464605D127
GO

Sequence cautioni

The sequence AAC19283 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80732 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48243 mRNA. Translation: CAA88288.1.
AF069298 Genomic DNA. Translation: AAC19283.1. Sequence problems.
AL161494 Genomic DNA. Translation: CAB80732.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE82163.1.
PIRiT01311.
RefSeqiNP_192148.2. NM_116472.4.
UniGeneiAt.92.

Genome annotation databases

EnsemblPlantsiAT4G02390.1; AT4G02390.1; AT4G02390.
GeneIDi828049.
GrameneiAT4G02390.1; AT4G02390.1; AT4G02390.
KEGGiath:AT4G02390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48243 mRNA. Translation: CAA88288.1.
AF069298 Genomic DNA. Translation: AAC19283.1. Sequence problems.
AL161494 Genomic DNA. Translation: CAB80732.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE82163.1.
PIRiT01311.
RefSeqiNP_192148.2. NM_116472.4.
UniGeneiAt.92.

3D structure databases

ProteinModelPortaliQ11207.
SMRiQ11207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi13340. 4 interactors.
STRINGi3702.AT4G02390.1.

PTM databases

iPTMnetiQ11207.

Proteomic databases

PaxDbiQ11207.
PRIDEiQ11207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G02390.1; AT4G02390.1; AT4G02390.
GeneIDi828049.
GrameneiAT4G02390.1; AT4G02390.1; AT4G02390.
KEGGiath:AT4G02390.

Organism-specific databases

TAIRiAT4G02390.

Phylogenomic databases

eggNOGiKOG1037. Eukaryota.
ENOG410XP18. LUCA.
HOGENOMiHOG000173055.
InParanoidiQ11207.
KOiK10798.
OMAiACSGDLN.
OrthoDBiEOG09360465.
PhylomeDBiQ11207.

Enzyme and pathway databases

BioCyciARA:AT4G02390-MONOMER.

Miscellaneous databases

PROiQ11207.

Gene expression databases

GenevisibleiQ11207. AT.

Family and domain databases

Gene3Di1.10.720.30. 2 hits.
1.20.142.10. 1 hit.
2.20.140.10. 1 hit.
3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004102. Poly(ADP-ribose)pol_reg_dom.
IPR003034. SAP_dom.
IPR008893. WGR_domain.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF02877. PARP_reg. 1 hit.
PF02037. SAP. 2 hits.
PF05406. WGR. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 2 hits.
SM00773. WGR. 1 hit.
[Graphical view]
SUPFAMiSSF142921. SSF142921. 1 hit.
SSF47587. SSF47587. 1 hit.
PROSITEiPS51060. PARP_ALPHA_HD. 1 hit.
PS51059. PARP_CATALYTIC. 1 hit.
PS50800. SAP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPARP2_ARATH
AccessioniPrimary (citable) accession number: Q11207
Secondary accession number(s): O81294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.