Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Gene

ST3GAL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant.By similarity1 Publication

Catalytic activityi

CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R = CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R.By similarity
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Source: BHF-UCL
  • monosialoganglioside sialyltransferase activity Source: BHF-UCL

GO - Biological processi

  • cognition Source: UniProtKB
  • glycolipid biosynthetic process Source: BHF-UCL
  • glycoprotein biosynthetic process Source: BHF-UCL
  • keratan sulfate biosynthetic process Source: Reactome
  • lipid glycosylation Source: BHF-UCL
  • O-glycan processing Source: Reactome
  • oligosaccharide biosynthetic process Source: BHF-UCL
  • oligosaccharide metabolic process Source: GO_Central
  • protein glycosylation Source: BHF-UCL
  • protein N-linked glycosylation via asparagine Source: GO_Central
  • protein sialylation Source: BHF-UCL
  • sialylation Source: BHF-UCL

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS03285-MONOMER
BRENDAi2.4.99.4 2681
2.4.99.6 2681
ReactomeiR-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-4085001 Sialic acid metabolism
R-HSA-975577 N-Glycan antennae elongation
R-HSA-977068 Termination of O-glycan biosynthesis
SIGNORiQ11206
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Chemistry databases

SwissLipidsiSLP:000001384

Names & Taxonomyi

Protein namesi
Recommended name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC:2.4.99.2By similarity, EC:2.4.99.4By similarity)
Short name:
Alpha 2,3-ST 4
Short name:
Beta-galactoside alpha-2,3-sialyltransferase 4
Alternative name(s):
Alpha 2,3-sialyltransferase IV
Gal-NAc6S
Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
SAT-3
ST-4
ST3Gal IV
Short name:
ST3GalIV
ST3GalA.2
STZ
Sialyltransferase 4C
Short name:
SIAT4-C
Gene namesi
Name:ST3GAL4
Synonyms:CGS23, NANTA3, SIAT4C, STZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110080.18
HGNCiHGNC:10864 ST3GAL4
MIMi104240 gene
neXtProtiNX_Q11206

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini27 – 333LumenalSequence analysisAdd BLAST307

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6484
OpenTargetsiENSG00000110080
PharmGKBiPA35766

Polymorphism and mutation databases

BioMutaiST3GAL4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492621 – 333CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi120 ↔ 273By similarity
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ11206
PaxDbiQ11206
PeptideAtlasiQ11206
PRIDEiQ11206
ProteomicsDBi58900
58901 [Q11206-2]
58902 [Q11206-3]
58903 [Q11206-4]
58904 [Q11206-5]

PTM databases

iPTMnetiQ11206
PhosphoSitePlusiQ11206

Expressioni

Tissue specificityi

Highly expressed in adult placenta, ovary and testes.

Gene expression databases

BgeeiENSG00000110080
CleanExiHS_ST3GAL4
ExpressionAtlasiQ11206 baseline and differential
GenevisibleiQ11206 HS

Organism-specific databases

HPAiHPA049827

Interactioni

Protein-protein interaction databases

BioGridi112377, 22 interactors
STRINGi9606.ENSP00000227495

Structurei

3D structure databases

ProteinModelPortaliQ11206
SMRiQ11206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00760000119095
HOGENOMiHOG000000682
HOVERGENiHBG056676
InParanoidiQ11206
KOiK03494
OMAiIHYYEQI
OrthoDBiEOG091G098L
PhylomeDBiQ11206
TreeFamiTF354325

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q11206-1) [UniParc]FASTAAdd to basket
Also known as: B1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSKSRWKLL AMLALVLVVM VWYSISREDR YIELFYFPIP EKKEPCLQGE
60 70 80 90 100
AESKASKLFG NYSRDQPIFL RLEDYFWVKT PSAYELPYGT KGSEDLLLRV
110 120 130 140 150
LAITSSSIPK NIQSLRCRRC VVVGNGHRLR NSSLGDAINK YDVVIRLNNA
160 170 180 190 200
PVAGYEGDVG SKTTMRLFYP ESAHFDPKVE NNPDTLLVLV AFKAMDFHWI
210 220 230 240 250
ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA ADKLLSLPMQ
260 270 280 290 300
QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDAYNKK QTIHYYEQIT
310 320 330
LKSMAGSGHN VSQEALAIKR MLEMGAIKNL TSF
Length:333
Mass (Da):38,045
Last modified:October 1, 1996 - v1
Checksum:i15E4BCE1F4F5B3C3
GO
Isoform 2 (identifier: Q11206-2) [UniParc]FASTAAdd to basket
Also known as: A1

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MVSKSR → MCPAG

Show »
Length:332
Mass (Da):37,816
Checksum:i3FF1B2BBAF273A03
GO
Isoform 3 (identifier: Q11206-3) [UniParc]FASTAAdd to basket
Also known as: A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:322
Mass (Da):36,745
Checksum:i3AA7031A765DF2BD
GO
Isoform 4 (identifier: Q11206-4) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: N → KLSPLCS

Show »
Length:339
Mass (Da):38,660
Checksum:iF48917FF5E9CAF87
GO
Isoform 5 (identifier: Q11206-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-34: RYIEL → S

Show »
Length:329
Mass (Da):37,458
Checksum:i3A1C52816B5BE9E8
GO
Isoform 6 (identifier: Q11206-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MVSKSR → MCPAG
     30-34: RYIEL → S

Show »
Length:328
Mass (Da):37,228
Checksum:i11CEDB415E141CDD
GO
Isoform 7 (identifier: Q11206-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.
     30-34: RYIEL → S

Show »
Length:318
Mass (Da):36,157
Checksum:iB8B413FF58A693F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182 – 183NP → KG in AAC14162 (PubMed:8611500).Curated2
Sequence conflicti200I → T in AAC14162 (PubMed:8611500).Curated1
Sequence conflicti304M → I in AAC14162 (PubMed:8611500).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0017851 – 11Missing in isoform 3 and isoform 7. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0017841 – 6MVSKSR → MCPAG in isoform 2 and isoform 6. 2 Publications6
Alternative sequenceiVSP_02110430 – 34RYIEL → S in isoform 5, isoform 6 and isoform 7. 2 Publications5
Alternative sequenceiVSP_00178661N → KLSPLCS in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23767 mRNA Translation: AAA16460.1
X74570 mRNA Translation: CAA52662.1
AF516603 mRNA Translation: AAM66432.1
AF516604 mRNA Translation: AAM66433.1
AY040826 mRNA Translation: AAK93790.1
AK291577 mRNA Translation: BAF84266.1
AP000806 Genomic DNA No translation available.
AP001318 Genomic DNA No translation available.
BC010645 mRNA Translation: AAH10645.1
AF035249 mRNA Translation: AAC14162.1
CCDSiCCDS58193.1 [Q11206-1]
CCDS58194.1 [Q11206-2]
CCDS8474.1 [Q11206-5]
PIRiA48715
A49879
RefSeqiNP_001241686.1, NM_001254757.1 [Q11206-1]
NP_001241687.1, NM_001254758.1 [Q11206-1]
NP_001241688.1, NM_001254759.1 [Q11206-2]
NP_001335328.1, NM_001348399.1 [Q11206-1]
NP_001335329.1, NM_001348400.1 [Q11206-5]
NP_006269.1, NM_006278.2 [Q11206-5]
UniGeneiHs.591947

Genome annotation databases

EnsembliENST00000227495; ENSP00000227495; ENSG00000110080 [Q11206-5]
ENST00000356132; ENSP00000348451; ENSG00000110080 [Q11206-4]
ENST00000392669; ENSP00000376437; ENSG00000110080 [Q11206-1]
ENST00000444328; ENSP00000394354; ENSG00000110080 [Q11206-1]
ENST00000449406; ENSP00000399444; ENSG00000110080 [Q11206-3]
ENST00000526727; ENSP00000436047; ENSG00000110080 [Q11206-1]
ENST00000530591; ENSP00000433989; ENSG00000110080 [Q11206-5]
ENST00000532243; ENSP00000434349; ENSG00000110080 [Q11206-2]
ENST00000534083; ENSP00000433318; ENSG00000110080 [Q11206-1]
ENST00000534457; ENSP00000434668; ENSG00000110080 [Q11206-6]
GeneIDi6484
KEGGihsa:6484
UCSCiuc001qds.4 human [Q11206-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSIA4C_HUMAN
AccessioniPrimary (citable) accession number: Q11206
Secondary accession number(s): A8K6B2
, O60497, Q8N6A6, Q8NFG7, Q96QQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health