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Protein

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Gene

ST3GAL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3-galactosyl derivative.1 Publication

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS03285-MONOMER.
BRENDAi2.4.99.4. 2681.
2.4.99.6. 2681.
ReactomeiR-HSA-1912420. Pre-NOTCH Processing in Golgi.
R-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-4085001. Sialic acid metabolism.
R-HSA-975577. N-Glycan antennae elongation.
R-HSA-977068. Termination of O-glycan biosynthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Chemistry databases

SwissLipidsiSLP:000001384.

Names & Taxonomyi

Protein namesi
Recommended name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC:2.4.99.-)
Short name:
Alpha 2,3-ST 4
Short name:
Beta-galactoside alpha-2,3-sialyltransferase 4
Alternative name(s):
Alpha 2,3-sialyltransferase IV
Gal-NAc6S
Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
SAT-3
ST-4
ST3Gal IV
Short name:
ST3GalIV
ST3GalA.2
STZ
Sialyltransferase 4C
Short name:
SIAT4-C
Gene namesi
Name:ST3GAL4
Synonyms:CGS23, NANTA3, SIAT4C, STZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10864. ST3GAL4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini27 – 333LumenalSequence analysisAdd BLAST307

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: Reactome
  • integral component of Golgi membrane Source: InterPro
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6484.
OpenTargetsiENSG00000110080.
PharmGKBiPA35766.

Polymorphism and mutation databases

BioMutaiST3GAL4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492621 – 333CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi120 ↔ 273By similarity
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi329N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ11206.
PaxDbiQ11206.
PeptideAtlasiQ11206.
PRIDEiQ11206.

PTM databases

iPTMnetiQ11206.
PhosphoSitePlusiQ11206.

Expressioni

Tissue specificityi

Highly expressed in adult placenta, ovary and testes.

Gene expression databases

BgeeiENSG00000110080.
CleanExiHS_ST3GAL4.
ExpressionAtlasiQ11206. baseline and differential.
GenevisibleiQ11206. HS.

Organism-specific databases

HPAiHPA049827.

Interactioni

Protein-protein interaction databases

BioGridi112377. 18 interactors.
STRINGi9606.ENSP00000227495.

Structurei

3D structure databases

ProteinModelPortaliQ11206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ11206.
KOiK03494.
OMAiIHYYEQI.
OrthoDBiEOG091G098L.
PhylomeDBiQ11206.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q11206-1) [UniParc]FASTAAdd to basket
Also known as: B1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSKSRWKLL AMLALVLVVM VWYSISREDR YIELFYFPIP EKKEPCLQGE
60 70 80 90 100
AESKASKLFG NYSRDQPIFL RLEDYFWVKT PSAYELPYGT KGSEDLLLRV
110 120 130 140 150
LAITSSSIPK NIQSLRCRRC VVVGNGHRLR NSSLGDAINK YDVVIRLNNA
160 170 180 190 200
PVAGYEGDVG SKTTMRLFYP ESAHFDPKVE NNPDTLLVLV AFKAMDFHWI
210 220 230 240 250
ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA ADKLLSLPMQ
260 270 280 290 300
QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDAYNKK QTIHYYEQIT
310 320 330
LKSMAGSGHN VSQEALAIKR MLEMGAIKNL TSF
Length:333
Mass (Da):38,045
Last modified:October 1, 1996 - v1
Checksum:i15E4BCE1F4F5B3C3
GO
Isoform 2 (identifier: Q11206-2) [UniParc]FASTAAdd to basket
Also known as: A1

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MVSKSR → MCPAG

Show »
Length:332
Mass (Da):37,816
Checksum:i3FF1B2BBAF273A03
GO
Isoform 3 (identifier: Q11206-3) [UniParc]FASTAAdd to basket
Also known as: A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:322
Mass (Da):36,745
Checksum:i3AA7031A765DF2BD
GO
Isoform 4 (identifier: Q11206-4) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: N → KLSPLCS

Show »
Length:339
Mass (Da):38,660
Checksum:iF48917FF5E9CAF87
GO
Isoform 5 (identifier: Q11206-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-34: RYIEL → S

Show »
Length:329
Mass (Da):37,458
Checksum:i3A1C52816B5BE9E8
GO
Isoform 6 (identifier: Q11206-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MVSKSR → MCPAG
     30-34: RYIEL → S

Show »
Length:328
Mass (Da):37,228
Checksum:i11CEDB415E141CDD
GO
Isoform 7 (identifier: Q11206-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.
     30-34: RYIEL → S

Show »
Length:318
Mass (Da):36,157
Checksum:iB8B413FF58A693F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182 – 183NP → KG in AAC14162 (PubMed:8611500).Curated2
Sequence conflicti200I → T in AAC14162 (PubMed:8611500).Curated1
Sequence conflicti304M → I in AAC14162 (PubMed:8611500).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0017851 – 11Missing in isoform 3 and isoform 7. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0017841 – 6MVSKSR → MCPAG in isoform 2 and isoform 6. 2 Publications6
Alternative sequenceiVSP_02110430 – 34RYIEL → S in isoform 5, isoform 6 and isoform 7. 2 Publications5
Alternative sequenceiVSP_00178661N → KLSPLCS in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23767 mRNA. Translation: AAA16460.1.
X74570 mRNA. Translation: CAA52662.1.
AF516603 mRNA. Translation: AAM66432.1.
AF516604 mRNA. Translation: AAM66433.1.
AY040826 mRNA. Translation: AAK93790.1.
AK291577 mRNA. Translation: BAF84266.1.
AP000806 Genomic DNA. No translation available.
AP001318 Genomic DNA. No translation available.
BC010645 mRNA. Translation: AAH10645.1.
AF035249 mRNA. Translation: AAC14162.1.
CCDSiCCDS58193.1. [Q11206-1]
CCDS58194.1. [Q11206-2]
CCDS8474.1. [Q11206-5]
PIRiA48715.
A49879.
RefSeqiNP_001241686.1. NM_001254757.1. [Q11206-1]
NP_001241687.1. NM_001254758.1. [Q11206-1]
NP_001241688.1. NM_001254759.1. [Q11206-2]
NP_006269.1. NM_006278.2. [Q11206-5]
XP_016873623.1. XM_017018134.1. [Q11206-5]
UniGeneiHs.591947.

Genome annotation databases

EnsembliENST00000227495; ENSP00000227495; ENSG00000110080. [Q11206-5]
ENST00000356132; ENSP00000348451; ENSG00000110080. [Q11206-4]
ENST00000392669; ENSP00000376437; ENSG00000110080. [Q11206-1]
ENST00000444328; ENSP00000394354; ENSG00000110080. [Q11206-1]
ENST00000449406; ENSP00000399444; ENSG00000110080. [Q11206-3]
ENST00000526727; ENSP00000436047; ENSG00000110080. [Q11206-1]
ENST00000530591; ENSP00000433989; ENSG00000110080. [Q11206-5]
ENST00000532243; ENSP00000434349; ENSG00000110080. [Q11206-2]
ENST00000534083; ENSP00000433318; ENSG00000110080. [Q11206-1]
ENST00000534457; ENSP00000434668; ENSG00000110080. [Q11206-6]
GeneIDi6484.
KEGGihsa:6484.
UCSCiuc001qds.4. human. [Q11206-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST3Gal IV

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23767 mRNA. Translation: AAA16460.1.
X74570 mRNA. Translation: CAA52662.1.
AF516603 mRNA. Translation: AAM66432.1.
AF516604 mRNA. Translation: AAM66433.1.
AY040826 mRNA. Translation: AAK93790.1.
AK291577 mRNA. Translation: BAF84266.1.
AP000806 Genomic DNA. No translation available.
AP001318 Genomic DNA. No translation available.
BC010645 mRNA. Translation: AAH10645.1.
AF035249 mRNA. Translation: AAC14162.1.
CCDSiCCDS58193.1. [Q11206-1]
CCDS58194.1. [Q11206-2]
CCDS8474.1. [Q11206-5]
PIRiA48715.
A49879.
RefSeqiNP_001241686.1. NM_001254757.1. [Q11206-1]
NP_001241687.1. NM_001254758.1. [Q11206-1]
NP_001241688.1. NM_001254759.1. [Q11206-2]
NP_006269.1. NM_006278.2. [Q11206-5]
XP_016873623.1. XM_017018134.1. [Q11206-5]
UniGeneiHs.591947.

3D structure databases

ProteinModelPortaliQ11206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112377. 18 interactors.
STRINGi9606.ENSP00000227495.

Chemistry databases

SwissLipidsiSLP:000001384.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

iPTMnetiQ11206.
PhosphoSitePlusiQ11206.

Polymorphism and mutation databases

BioMutaiST3GAL4.

Proteomic databases

MaxQBiQ11206.
PaxDbiQ11206.
PeptideAtlasiQ11206.
PRIDEiQ11206.

Protocols and materials databases

DNASUi6484.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227495; ENSP00000227495; ENSG00000110080. [Q11206-5]
ENST00000356132; ENSP00000348451; ENSG00000110080. [Q11206-4]
ENST00000392669; ENSP00000376437; ENSG00000110080. [Q11206-1]
ENST00000444328; ENSP00000394354; ENSG00000110080. [Q11206-1]
ENST00000449406; ENSP00000399444; ENSG00000110080. [Q11206-3]
ENST00000526727; ENSP00000436047; ENSG00000110080. [Q11206-1]
ENST00000530591; ENSP00000433989; ENSG00000110080. [Q11206-5]
ENST00000532243; ENSP00000434349; ENSG00000110080. [Q11206-2]
ENST00000534083; ENSP00000433318; ENSG00000110080. [Q11206-1]
ENST00000534457; ENSP00000434668; ENSG00000110080. [Q11206-6]
GeneIDi6484.
KEGGihsa:6484.
UCSCiuc001qds.4. human. [Q11206-1]

Organism-specific databases

CTDi6484.
DisGeNETi6484.
GeneCardsiST3GAL4.
HGNCiHGNC:10864. ST3GAL4.
HPAiHPA049827.
MIMi104240. gene.
neXtProtiNX_Q11206.
OpenTargetsiENSG00000110080.
PharmGKBiPA35766.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ11206.
KOiK03494.
OMAiIHYYEQI.
OrthoDBiEOG091G098L.
PhylomeDBiQ11206.
TreeFamiTF354325.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciZFISH:HS03285-MONOMER.
BRENDAi2.4.99.4. 2681.
2.4.99.6. 2681.
ReactomeiR-HSA-1912420. Pre-NOTCH Processing in Golgi.
R-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-4085001. Sialic acid metabolism.
R-HSA-975577. N-Glycan antennae elongation.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiST3GAL4. human.
GeneWikiiST3GAL4.
GenomeRNAii6484.
PROiQ11206.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110080.
CleanExiHS_ST3GAL4.
ExpressionAtlasiQ11206. baseline and differential.
GenevisibleiQ11206. HS.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIA4C_HUMAN
AccessioniPrimary (citable) accession number: Q11206
Secondary accession number(s): A8K6B2
, O60497, Q8N6A6, Q8NFG7, Q96QQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.