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Q11206

- SIA4C_HUMAN

UniProt

Q11206 - SIA4C_HUMAN

Protein

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Gene

ST3GAL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3-galactosyl derivative.1 Publication

    Catalytic activityi

    CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein.

    Pathwayi

    GO - Molecular functioni

    1. beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Source: ProtInc
    2. monosialoganglioside sialyltransferase activity Source: Ensembl

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. cognition Source: UniProt
    4. glycosaminoglycan metabolic process Source: Reactome
    5. keratan sulfate biosynthetic process Source: Reactome
    6. keratan sulfate metabolic process Source: Reactome
    7. O-glycan processing Source: Reactome
    8. post-translational protein modification Source: Reactome
    9. protein N-linked glycosylation via asparagine Source: Reactome
    10. sialylation Source: GOC
    11. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_115835. Termination of O-glycan biosynthesis.
    REACT_118798. Pre-NOTCH Processing in Golgi.
    REACT_121120. Keratan sulfate biosynthesis.
    REACT_200874. Sialic acid metabolism.
    REACT_25085. N-Glycan antennae elongation.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC:2.4.99.-)
    Short name:
    Alpha 2,3-ST 4
    Short name:
    Beta-galactoside alpha-2,3-sialyltransferase 4
    Alternative name(s):
    Alpha 2,3-sialyltransferase IV
    Gal-NAc6S
    Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
    SAT-3
    ST-4
    ST3Gal IV
    Short name:
    ST3GalIV
    ST3GalA.2
    STZ
    Sialyltransferase 4C
    Short name:
    SIAT4-C
    Gene namesi
    Name:ST3GAL4
    Synonyms:CGS23, NANTA3, SIAT4C, STZ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10864. ST3GAL4.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein. Secreted
    Note: Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi cisterna membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: Reactome
    4. integral component of Golgi membrane Source: InterPro
    5. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35766.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4PRO_0000149262Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 273By similarity
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The soluble form derives from the membrane form by proteolytic processing.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ11206.
    PaxDbiQ11206.
    PRIDEiQ11206.

    PTM databases

    PhosphoSiteiQ11206.

    Expressioni

    Tissue specificityi

    Highly expressed in adult placenta, ovary and testes.

    Gene expression databases

    ArrayExpressiQ11206.
    BgeeiQ11206.
    CleanExiHS_ST3GAL4.
    GenevestigatoriQ11206.

    Organism-specific databases

    HPAiHPA049827.

    Interactioni

    Protein-protein interaction databases

    BioGridi112377. 1 interaction.
    STRINGi9606.ENSP00000227495.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11206.
    SMRiQ11206. Positions 118-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini27 – 333307LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2618Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG284110.
    HOGENOMiHOG000000682.
    HOVERGENiHBG056676.
    KOiK03494.
    OMAiIHYYEQI.
    PhylomeDBiQ11206.
    TreeFamiTF354325.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q11206-1) [UniParc]FASTAAdd to Basket

    Also known as: B1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVSKSRWKLL AMLALVLVVM VWYSISREDR YIELFYFPIP EKKEPCLQGE    50
    AESKASKLFG NYSRDQPIFL RLEDYFWVKT PSAYELPYGT KGSEDLLLRV 100
    LAITSSSIPK NIQSLRCRRC VVVGNGHRLR NSSLGDAINK YDVVIRLNNA 150
    PVAGYEGDVG SKTTMRLFYP ESAHFDPKVE NNPDTLLVLV AFKAMDFHWI 200
    ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA ADKLLSLPMQ 250
    QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDAYNKK QTIHYYEQIT 300
    LKSMAGSGHN VSQEALAIKR MLEMGAIKNL TSF 333
    Length:333
    Mass (Da):38,045
    Last modified:October 1, 1996 - v1
    Checksum:i15E4BCE1F4F5B3C3
    GO
    Isoform 2 (identifier: Q11206-2) [UniParc]FASTAAdd to Basket

    Also known as: A1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MVSKSR → MCPAG

    Show »
    Length:332
    Mass (Da):37,816
    Checksum:i3FF1B2BBAF273A03
    GO
    Isoform 3 (identifier: Q11206-3) [UniParc]FASTAAdd to Basket

    Also known as: A2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.

    Show »
    Length:322
    Mass (Da):36,745
    Checksum:i3AA7031A765DF2BD
    GO
    Isoform 4 (identifier: Q11206-4) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         61-61: N → KLSPLCS

    Show »
    Length:339
    Mass (Da):38,660
    Checksum:iF48917FF5E9CAF87
    GO
    Isoform 5 (identifier: Q11206-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         30-34: RYIEL → S

    Show »
    Length:329
    Mass (Da):37,458
    Checksum:i3A1C52816B5BE9E8
    GO
    Isoform 6 (identifier: Q11206-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MVSKSR → MCPAG
         30-34: RYIEL → S

    Show »
    Length:328
    Mass (Da):37,228
    Checksum:i11CEDB415E141CDD
    GO
    Isoform 7 (identifier: Q11206-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.
         30-34: RYIEL → S

    Show »
    Length:318
    Mass (Da):36,157
    Checksum:iB8B413FF58A693F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti182 – 1832NP → KG in AAC14162. (PubMed:8611500)Curated
    Sequence conflicti200 – 2001I → T in AAC14162. (PubMed:8611500)Curated
    Sequence conflicti304 – 3041M → I in AAC14162. (PubMed:8611500)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1111Missing in isoform 3 and isoform 7. 1 PublicationVSP_001785Add
    BLAST
    Alternative sequencei1 – 66MVSKSR → MCPAG in isoform 2 and isoform 6. 2 PublicationsVSP_001784
    Alternative sequencei30 – 345RYIEL → S in isoform 5, isoform 6 and isoform 7. 2 PublicationsVSP_021104
    Alternative sequencei61 – 611N → KLSPLCS in isoform 4. 2 PublicationsVSP_001786

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23767 mRNA. Translation: AAA16460.1.
    X74570 mRNA. Translation: CAA52662.1.
    AF516603 mRNA. Translation: AAM66432.1.
    AF516604 mRNA. Translation: AAM66433.1.
    AY040826 mRNA. Translation: AAK93790.1.
    AK291577 mRNA. Translation: BAF84266.1.
    AP000806 Genomic DNA. No translation available.
    AP001318 Genomic DNA. No translation available.
    BC010645 mRNA. Translation: AAH10645.1.
    AF035249 mRNA. Translation: AAC14162.1.
    CCDSiCCDS58193.1. [Q11206-1]
    CCDS58194.1. [Q11206-2]
    CCDS8474.1. [Q11206-5]
    PIRiA48715.
    A49879.
    RefSeqiNP_001241686.1. NM_001254757.1. [Q11206-1]
    NP_001241687.1. NM_001254758.1. [Q11206-1]
    NP_001241688.1. NM_001254759.1. [Q11206-2]
    NP_006269.1. NM_006278.2. [Q11206-5]
    XP_005271707.1. XM_005271650.1. [Q11206-1]
    XP_005271708.1. XM_005271651.1. [Q11206-5]
    UniGeneiHs.591947.

    Genome annotation databases

    EnsembliENST00000227495; ENSP00000227495; ENSG00000110080. [Q11206-5]
    ENST00000356132; ENSP00000348451; ENSG00000110080. [Q11206-4]
    ENST00000392669; ENSP00000376437; ENSG00000110080. [Q11206-1]
    ENST00000444328; ENSP00000394354; ENSG00000110080. [Q11206-1]
    ENST00000449406; ENSP00000399444; ENSG00000110080. [Q11206-3]
    ENST00000526727; ENSP00000436047; ENSG00000110080. [Q11206-1]
    ENST00000530591; ENSP00000433989; ENSG00000110080. [Q11206-5]
    ENST00000532243; ENSP00000434349; ENSG00000110080. [Q11206-2]
    ENST00000534083; ENSP00000433318; ENSG00000110080. [Q11206-1]
    ENST00000534457; ENSP00000434668; ENSG00000110080. [Q11206-6]
    GeneIDi6484.
    KEGGihsa:6484.
    UCSCiuc001qds.3. human. [Q11206-1]
    uc001qdw.3. human. [Q11206-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    ST3Gal IV

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23767 mRNA. Translation: AAA16460.1 .
    X74570 mRNA. Translation: CAA52662.1 .
    AF516603 mRNA. Translation: AAM66432.1 .
    AF516604 mRNA. Translation: AAM66433.1 .
    AY040826 mRNA. Translation: AAK93790.1 .
    AK291577 mRNA. Translation: BAF84266.1 .
    AP000806 Genomic DNA. No translation available.
    AP001318 Genomic DNA. No translation available.
    BC010645 mRNA. Translation: AAH10645.1 .
    AF035249 mRNA. Translation: AAC14162.1 .
    CCDSi CCDS58193.1. [Q11206-1 ]
    CCDS58194.1. [Q11206-2 ]
    CCDS8474.1. [Q11206-5 ]
    PIRi A48715.
    A49879.
    RefSeqi NP_001241686.1. NM_001254757.1. [Q11206-1 ]
    NP_001241687.1. NM_001254758.1. [Q11206-1 ]
    NP_001241688.1. NM_001254759.1. [Q11206-2 ]
    NP_006269.1. NM_006278.2. [Q11206-5 ]
    XP_005271707.1. XM_005271650.1. [Q11206-1 ]
    XP_005271708.1. XM_005271651.1. [Q11206-5 ]
    UniGenei Hs.591947.

    3D structure databases

    ProteinModelPortali Q11206.
    SMRi Q11206. Positions 118-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112377. 1 interaction.
    STRINGi 9606.ENSP00000227495.

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    PTM databases

    PhosphoSitei Q11206.

    Proteomic databases

    MaxQBi Q11206.
    PaxDbi Q11206.
    PRIDEi Q11206.

    Protocols and materials databases

    DNASUi 6484.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000227495 ; ENSP00000227495 ; ENSG00000110080 . [Q11206-5 ]
    ENST00000356132 ; ENSP00000348451 ; ENSG00000110080 . [Q11206-4 ]
    ENST00000392669 ; ENSP00000376437 ; ENSG00000110080 . [Q11206-1 ]
    ENST00000444328 ; ENSP00000394354 ; ENSG00000110080 . [Q11206-1 ]
    ENST00000449406 ; ENSP00000399444 ; ENSG00000110080 . [Q11206-3 ]
    ENST00000526727 ; ENSP00000436047 ; ENSG00000110080 . [Q11206-1 ]
    ENST00000530591 ; ENSP00000433989 ; ENSG00000110080 . [Q11206-5 ]
    ENST00000532243 ; ENSP00000434349 ; ENSG00000110080 . [Q11206-2 ]
    ENST00000534083 ; ENSP00000433318 ; ENSG00000110080 . [Q11206-1 ]
    ENST00000534457 ; ENSP00000434668 ; ENSG00000110080 . [Q11206-6 ]
    GeneIDi 6484.
    KEGGi hsa:6484.
    UCSCi uc001qds.3. human. [Q11206-1 ]
    uc001qdw.3. human. [Q11206-2 ]

    Organism-specific databases

    CTDi 6484.
    GeneCardsi GC11P126225.
    HGNCi HGNC:10864. ST3GAL4.
    HPAi HPA049827.
    MIMi 104240. gene.
    neXtProti NX_Q11206.
    PharmGKBi PA35766.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284110.
    HOGENOMi HOG000000682.
    HOVERGENi HBG056676.
    KOi K03494.
    OMAi IHYYEQI.
    PhylomeDBi Q11206.
    TreeFami TF354325.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_115835. Termination of O-glycan biosynthesis.
    REACT_118798. Pre-NOTCH Processing in Golgi.
    REACT_121120. Keratan sulfate biosynthesis.
    REACT_200874. Sialic acid metabolism.
    REACT_25085. N-Glycan antennae elongation.

    Miscellaneous databases

    ChiTaRSi ST3GAL4. human.
    GeneWikii ST3GAL4.
    GenomeRNAii 6484.
    NextBioi 25191.
    PROi Q11206.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q11206.
    Bgeei Q11206.
    CleanExi HS_ST3GAL4.
    Genevestigatori Q11206.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase."
      Kitagawa H., Mattei M.-G., Paulson J.C.
      J. Biol. Chem. 271:931-938(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups."
      Kitagawa H., Paulson J.C.
      J. Biol. Chem. 269:1394-1401(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection."
      Sasaki K., Watanabe E., Kawashima K., Sekine S., Dohi T., Oshima M., Hanai N., Nishi T., Hasegawa M.
      J. Biol. Chem. 268:22782-22787(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    4. "Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues."
      Grahn A., Larson G.
      Glycoconj. J. 18:759-767(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 6 AND 7), ALTERNATIVE SPLICING.
      Tissue: Peripheral blood leukocyte.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Placenta.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    8. "Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line."
      Basu S.S., Basu M., Li Z., Basu S.
      Biochemistry 35:5166-5174(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-314, FUNCTION.
      Tissue: Colon carcinoma.

    Entry informationi

    Entry nameiSIA4C_HUMAN
    AccessioniPrimary (citable) accession number: Q11206
    Secondary accession number(s): A8K6B2
    , O60497, Q8N6A6, Q8NFG7, Q96QQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3