Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Gene

let-721

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Accepts electrons from ETF and reduces ubiquinone.By similarity

Catalytic activityi

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei285 – 2851Ubiquinone; via carbonyl oxygenBy similarity
Binding sitei286 – 2861Ubiquinone; via amide nitrogenBy similarity
Metal bindingi540 – 5401Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi566 – 5661Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi569 – 5691Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi572 – 5721Iron-sulfur (4Fe-4S)Sequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 6715FADSequence analysisAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Ubiquinone

Enzyme and pathway databases

ReactomeiR-CEL-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (EC:1.5.5.1)
Short name:
ETF-QO
Short name:
ETF-ubiquinone oxidoreductase
Alternative name(s):
Electron-transferring-flavoprotein dehydrogenase
Short name:
ETF dehydrogenase
Lethal protein 721
Gene namesi
Name:let-721
ORF Names:C05D11.12
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC05D11.12; CE29662; WBGene00002855; let-721.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei91 – 11222By similarityAdd
BLAST
Intramembranei409 – 42618By similarityAdd
BLAST

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 597Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialPRO_0000008665
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ11190.
PaxDbiQ11190.
PRIDEiQ11190.

2D gel databases

World-2DPAGE0020:Q11190.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi6239.C05D11.12.1.

Structurei

3D structure databases

ProteinModelPortaliQ11190.
SMRiQ11190. Positions 25-597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini557 – 586304Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETF-QO/FixC family.Curated
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
GeneTreeiENSGT00390000010773.
HOGENOMiHOG000259450.
InParanoidiQ11190.
KOiK00311.
OMAiFKLDQNS.
OrthoDBiEOG7WX07W.
PhylomeDBiQ11190.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q11190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISGVTLFR VSSQLRNVVN GQWTTTHYTV KDRSTDPRWK DVDLARESDV
60 70 80 90 100
YDVVIVGGGP SGLSAAIRLR QLAEKAQKEL RVCVVEKASV IGGHTLSGAV
110 120 130 140 150
IETRALDELI PNWKELGAPV YQQVTSESIA ILTESGRIPV PVLPGVPLAN
160 170 180 190 200
HGNYIVRLGK VVQWLGEQAE AAGVEVWPEI AASEVLYNED GSVKGIATSD
210 220 230 240 250
VGIGKDGAPK DGFARGMEFH AKCTIFAEGC RGHLSKQVLD KFDLRTHAMT
260 270 280 290 300
YGIGLKELWE IDPAKHRPGY VEHTMGWPLN VDQYGGSFLY HIEDQGQPLV
310 320 330 340 350
SVGFVVALDY ANPNLNPYKE FQKYKTHPSI SKQLEGGKRI GYGARALNEG
360 370 380 390 400
GFQSIPKLHF PGGCLVGCSA GFLNVAKLKG THNAMKSGMV AAESIFEDIQ
410 420 430 440 450
QKGEDVQTID PATYDKNIRD TYVVKELKAT RNIRPSFNTS LGYIGGLIYS
460 470 480 490 500
GIFYVFGRGI EPWTLGHGKK DNEKLIPVKD AKEIDYPKPD GKLTFDLLTS
510 520 530 540 550
VSLTGTNHTE DQPAHLTLKN DQVPLDVNLA VYGGPEARFC PAGVYEFVPS
560 570 580 590
EADESKKRLQ INAQNCIHCK TCDIKDPQQN INWVTPEGGG GPKYEGM
Length:597
Mass (Da):65,335
Last modified:May 27, 2002 - v2
Checksum:iC0FF09F185A017FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080365 Genomic DNA. Translation: CCD63203.1.
PIRiD88483.
RefSeqiNP_498415.2. NM_066014.6.
UniGeneiCel.17705.

Genome annotation databases

EnsemblMetazoaiC05D11.12.1; C05D11.12.1; WBGene00002855.
C05D11.12.2; C05D11.12.2; WBGene00002855.
GeneIDi175916.
KEGGicel:CELE_C05D11.12.
UCSCiC05D11.12.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080365 Genomic DNA. Translation: CCD63203.1.
PIRiD88483.
RefSeqiNP_498415.2. NM_066014.6.
UniGeneiCel.17705.

3D structure databases

ProteinModelPortaliQ11190.
SMRiQ11190. Positions 25-597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C05D11.12.1.

2D gel databases

World-2DPAGE0020:Q11190.

Proteomic databases

EPDiQ11190.
PaxDbiQ11190.
PRIDEiQ11190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC05D11.12.1; C05D11.12.1; WBGene00002855.
C05D11.12.2; C05D11.12.2; WBGene00002855.
GeneIDi175916.
KEGGicel:CELE_C05D11.12.
UCSCiC05D11.12.1. c. elegans.

Organism-specific databases

CTDi175916.
WormBaseiC05D11.12; CE29662; WBGene00002855; let-721.

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
GeneTreeiENSGT00390000010773.
HOGENOMiHOG000259450.
InParanoidiQ11190.
KOiK00311.
OMAiFKLDQNS.
OrthoDBiEOG7WX07W.
PhylomeDBiQ11190.

Enzyme and pathway databases

ReactomeiR-CEL-611105. Respiratory electron transport.

Miscellaneous databases

PROiQ11190.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiETFD_CAEEL
AccessioniPrimary (citable) accession number: Q11190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: June 8, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.