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Q11179

- YPC2_CAEEL

UniProt

Q11179 - YPC2_CAEEL

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Protein
Putative serine/threonine-protein kinase C05D10.2
Gene
C05D10.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATP By similarity
Active sitei137 – 1371Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ11179.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein kinase C05D10.2 (EC:2.7.11.24)
Gene namesi
ORF Names:C05D10.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC05D10.2a; CE29020; WBGene00015478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Putative serine/threonine-protein kinase C05D10.2
PRO_0000186307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781Phosphothreonine By similarity
Modified residuei180 – 1801Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ11179.
PRIDEiQ11179.

Structurei

3D structure databases

ProteinModelPortaliQ11179.
SMRiQ11179. Positions 5-361.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 306294Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi178 – 1803TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110881.
HOGENOMiHOG000233024.
InParanoidiQ11179.
KOiK08293.
OMAiCTVKLCD.
PhylomeDBiQ11179.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11179-1 [UniParc]FASTAAdd to Basket

« Hide

MTDDVDTHIH EKFDLQKRLG KGAYGIVWKA YDKRSRETVA LKKIFDAFRN    50
PTDSQRTFRE VMFLQEFGKH PNVIKLYNIF RADNDRDIYL AFEFMEADLH 100
NVIKKGSILK DVHKQYIMCQ LFRAIRFLHS GNVLHRDLKP SNVLLDADCR 150
VKLADFGLAR SLSSLEDYPE GQKMPDLTEY VATRWYRSPE ILLAAKRYTK 200
GVDMWSLGCI LAEMLIGRAL FPGSSTINQI ERIMNTIAKP SRADIASIGS 250
HYAASVLEKM PQRPRKPLDL IITQSQTAAI DMVQRLLIFA PQKRLTVEQC 300
LVHPYVVQFH NPSEEPVLNY EVYPPLPDHI QLSIDDYRDR LYEMIDEKKA 350
SFKRIQHEKI RPYGEDKSRA PIAQAECSDT DYDTARSLQR TTSMDKNNSS 400
SHDSSSGTLR ERAASAESRT SKDSNGEMRN GNGNTPSSIK QRRRSVERAR 450
LFANIKPSKI LHPHKLISNY 470
Length:470
Mass (Da):54,039
Last modified:June 6, 2002 - v2
Checksum:i8908B49D15173DF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080362 Genomic DNA. Translation: CCD63173.1.
PIRiH88473.
RefSeqiNP_741165.1. NM_171144.4.
UniGeneiCel.10889.

Genome annotation databases

EnsemblMetazoaiC05D10.2a; C05D10.2a; WBGene00015478.
GeneIDi175857.
KEGGicel:CELE_C05D10.2.
UCSCiC05D10.2c. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080362 Genomic DNA. Translation: CCD63173.1 .
PIRi H88473.
RefSeqi NP_741165.1. NM_171144.4.
UniGenei Cel.10889.

3D structure databases

ProteinModelPortali Q11179.
SMRi Q11179. Positions 5-361.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q11179.
PRIDEi Q11179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C05D10.2a ; C05D10.2a ; WBGene00015478 .
GeneIDi 175857.
KEGGi cel:CELE_C05D10.2.
UCSCi C05D10.2c. c. elegans.

Organism-specific databases

CTDi 175857.
WormBasei C05D10.2a ; CE29020 ; WBGene00015478 .

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110881.
HOGENOMi HOG000233024.
InParanoidi Q11179.
KOi K08293.
OMAi CTVKLCD.
PhylomeDBi Q11179.

Enzyme and pathway databases

SignaLinki Q11179.

Miscellaneous databases

NextBioi 889996.
PROi Q11179.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYPC2_CAEEL
AccessioniPrimary (citable) accession number: Q11179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 6, 2002
Last modified: June 11, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi