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Protein

Putative serine/threonine-protein kinase C05D10.2

Gene

C05D10.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATPPROSITE-ProRule annotation
Active sitei137 – 1371Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ11179.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein kinase C05D10.2 (EC:2.7.11.24)
Gene namesi
ORF Names:C05D10.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC05D10.2a; CE29020; WBGene00015478.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Putative serine/threonine-protein kinase C05D10.2PRO_0000186307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781PhosphothreonineBy similarity
Modified residuei180 – 1801PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ11179.
PRIDEiQ11179.

Expressioni

Gene expression databases

ExpressionAtlasiQ11179. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.C05D10.2a.

Structurei

3D structure databases

ProteinModelPortaliQ11179.
SMRiQ11179. Positions 5-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 306294Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi178 – 1803TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00550000074298.
HOGENOMiHOG000233024.
InParanoidiQ11179.
KOiK08293.
OMAiGFEYMET.
PhylomeDBiQ11179.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDVDTHIH EKFDLQKRLG KGAYGIVWKA YDKRSRETVA LKKIFDAFRN
60 70 80 90 100
PTDSQRTFRE VMFLQEFGKH PNVIKLYNIF RADNDRDIYL AFEFMEADLH
110 120 130 140 150
NVIKKGSILK DVHKQYIMCQ LFRAIRFLHS GNVLHRDLKP SNVLLDADCR
160 170 180 190 200
VKLADFGLAR SLSSLEDYPE GQKMPDLTEY VATRWYRSPE ILLAAKRYTK
210 220 230 240 250
GVDMWSLGCI LAEMLIGRAL FPGSSTINQI ERIMNTIAKP SRADIASIGS
260 270 280 290 300
HYAASVLEKM PQRPRKPLDL IITQSQTAAI DMVQRLLIFA PQKRLTVEQC
310 320 330 340 350
LVHPYVVQFH NPSEEPVLNY EVYPPLPDHI QLSIDDYRDR LYEMIDEKKA
360 370 380 390 400
SFKRIQHEKI RPYGEDKSRA PIAQAECSDT DYDTARSLQR TTSMDKNNSS
410 420 430 440 450
SHDSSSGTLR ERAASAESRT SKDSNGEMRN GNGNTPSSIK QRRRSVERAR
460 470
LFANIKPSKI LHPHKLISNY
Length:470
Mass (Da):54,039
Last modified:June 6, 2002 - v2
Checksum:i8908B49D15173DF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080362 Genomic DNA. Translation: CCD63173.1.
PIRiH88473.
RefSeqiNP_741165.1. NM_171144.4.
UniGeneiCel.10889.

Genome annotation databases

EnsemblMetazoaiC05D10.2a; C05D10.2a; WBGene00015478.
GeneIDi175857.
KEGGicel:CELE_C05D10.2.
UCSCiC05D10.2c. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080362 Genomic DNA. Translation: CCD63173.1.
PIRiH88473.
RefSeqiNP_741165.1. NM_171144.4.
UniGeneiCel.10889.

3D structure databases

ProteinModelPortaliQ11179.
SMRiQ11179. Positions 5-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C05D10.2a.

Proteomic databases

PaxDbiQ11179.
PRIDEiQ11179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC05D10.2a; C05D10.2a; WBGene00015478.
GeneIDi175857.
KEGGicel:CELE_C05D10.2.
UCSCiC05D10.2c. c. elegans.

Organism-specific databases

CTDi175857.
WormBaseiC05D10.2a; CE29020; WBGene00015478.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00550000074298.
HOGENOMiHOG000233024.
InParanoidiQ11179.
KOiK08293.
OMAiGFEYMET.
PhylomeDBiQ11179.

Enzyme and pathway databases

SignaLinkiQ11179.

Miscellaneous databases

NextBioi889996.
PROiQ11179.

Gene expression databases

ExpressionAtlasiQ11179. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYPC2_CAEEL
AccessioniPrimary (citable) accession number: Q11179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 6, 2002
Last modified: June 24, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.