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Protein

Mitogen-activated protein kinase 15

Gene

mapk-15

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in male mating behavior, probably in part through regulating the localization of the polycystin pkd-2. May play a role in the function of ciliated sensory neurons.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei137Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processBehavior, Cilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ11179

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 15Curated (EC:2.7.11.24)
Gene namesi
Name:mapk-151 PublicationImported
ORF Names:C05D10.2Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC05D10.2a ; CE29020 ; WBGene00015478 ; mapk-15
C05D10.2b ; CE30421 ; WBGene00015478 ; mapk-15
C05D10.2c ; CE30422 ; WBGene00015478 ; mapk-15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Viable, but males display irregular mating behavior. Ciliary defects in ciliated sensory neurons including impaired extension of dendrites.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001863071 – 470Mitogen-activated protein kinase 15CuratedAdd BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphothreonineBy similarity1
Modified residuei180PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ11179
PeptideAtlasiQ11179
PRIDEiQ11179

Expressioni

Tissue specificityi

Isoform a: Expressed in head and tail ciliated sensory neurons, and in mid-body neurons. Isoform c: Expressed in head and tail ciliated sensory neurons, and in mid-body neurons.1 Publication

Gene expression databases

BgeeiWBGene00015478
ExpressionAtlasiQ11179 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi6239.C05D10.2a

Structurei

3D structure databases

ProteinModelPortaliQ11179
SMRiQ11179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 306Protein kinasePROSITE-ProRule annotationAdd BLAST294

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi178 – 180TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00910000144035
HOGENOMiHOG000233024
InParanoidiQ11179
KOiK19603
OMAiIRGDWNR
OrthoDBiEOG091G08QL
PhylomeDBiQ11179

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: Q11179-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDDVDTHIH EKFDLQKRLG KGAYGIVWKA YDKRSRETVA LKKIFDAFRN
60 70 80 90 100
PTDSQRTFRE VMFLQEFGKH PNVIKLYNIF RADNDRDIYL AFEFMEADLH
110 120 130 140 150
NVIKKGSILK DVHKQYIMCQ LFRAIRFLHS GNVLHRDLKP SNVLLDADCR
160 170 180 190 200
VKLADFGLAR SLSSLEDYPE GQKMPDLTEY VATRWYRSPE ILLAAKRYTK
210 220 230 240 250
GVDMWSLGCI LAEMLIGRAL FPGSSTINQI ERIMNTIAKP SRADIASIGS
260 270 280 290 300
HYAASVLEKM PQRPRKPLDL IITQSQTAAI DMVQRLLIFA PQKRLTVEQC
310 320 330 340 350
LVHPYVVQFH NPSEEPVLNY EVYPPLPDHI QLSIDDYRDR LYEMIDEKKA
360 370 380 390 400
SFKRIQHEKI RPYGEDKSRA PIAQAECSDT DYDTARSLQR TTSMDKNNSS
410 420 430 440 450
SHDSSSGTLR ERAASAESRT SKDSNGEMRN GNGNTPSSIK QRRRSVERAR
460 470
LFANIKPSKI LHPHKLISNY
Length:470
Mass (Da):54,039
Last modified:June 6, 2002 - v2
Checksum:i8908B49D15173DF0
GO
Isoform bImported (identifier: Q11179-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-470: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:86
Mass (Da):10,279
Checksum:i10E0E4CA8180C20D
GO
Isoform cImported (identifier: Q11179-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-367: YGEDK → VVRRR
     368-470: Missing.

Show »
Length:367
Mass (Da):42,736
Checksum:iB1FFA74CF1839C3F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05912887 – 470Missing in isoform b. CuratedAdd BLAST384
Alternative sequenceiVSP_059129363 – 367YGEDK → VVRRR in isoform c. Curated5
Alternative sequenceiVSP_059130368 – 470Missing in isoform c. CuratedAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080362 Genomic DNA Translation: CCD63173.1
BX284603 Genomic DNA Translation: CCD63174.1
BX284603 Genomic DNA Translation: CCD63175.1
PIRiH88473
RefSeqiNP_741165.1, NM_171144.4 [Q11179-1]
NP_741166.1, NM_171145.4
NP_741167.1, NM_171146.3
UniGeneiCel.10889

Genome annotation databases

EnsemblMetazoaiC05D10.2a; C05D10.2a; WBGene00015478 [Q11179-1]
C05D10.2b; C05D10.2b; WBGene00015478 [Q11179-2]
C05D10.2c; C05D10.2c; WBGene00015478 [Q11179-3]
GeneIDi175857
KEGGicel:CELE_C05D10.2
UCSCiC05D10.2c c. elegans [Q11179-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMK15_CAEEL
AccessioniPrimary (citable) accession number: Q11179
Secondary accession number(s): G8JY04, Q8T3F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 6, 2002
Last modified: March 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health