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Q11179

- YPC2_CAEEL

UniProt

Q11179 - YPC2_CAEEL

Protein

Putative serine/threonine-protein kinase C05D10.2

Gene

C05D10.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation
    Active sitei137 – 1371Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ11179.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative serine/threonine-protein kinase C05D10.2 (EC:2.7.11.24)
    Gene namesi
    ORF Names:C05D10.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC05D10.2a; CE29020; WBGene00015478.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Putative serine/threonine-protein kinase C05D10.2PRO_0000186307Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei178 – 1781PhosphothreonineBy similarity
    Modified residuei180 – 1801PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ11179.
    PRIDEiQ11179.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11179.
    SMRiQ11179. Positions 5-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 306294Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi178 – 1803TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110881.
    HOGENOMiHOG000233024.
    InParanoidiQ11179.
    KOiK08293.
    OMAiCTVKLCD.
    PhylomeDBiQ11179.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q11179-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDDVDTHIH EKFDLQKRLG KGAYGIVWKA YDKRSRETVA LKKIFDAFRN    50
    PTDSQRTFRE VMFLQEFGKH PNVIKLYNIF RADNDRDIYL AFEFMEADLH 100
    NVIKKGSILK DVHKQYIMCQ LFRAIRFLHS GNVLHRDLKP SNVLLDADCR 150
    VKLADFGLAR SLSSLEDYPE GQKMPDLTEY VATRWYRSPE ILLAAKRYTK 200
    GVDMWSLGCI LAEMLIGRAL FPGSSTINQI ERIMNTIAKP SRADIASIGS 250
    HYAASVLEKM PQRPRKPLDL IITQSQTAAI DMVQRLLIFA PQKRLTVEQC 300
    LVHPYVVQFH NPSEEPVLNY EVYPPLPDHI QLSIDDYRDR LYEMIDEKKA 350
    SFKRIQHEKI RPYGEDKSRA PIAQAECSDT DYDTARSLQR TTSMDKNNSS 400
    SHDSSSGTLR ERAASAESRT SKDSNGEMRN GNGNTPSSIK QRRRSVERAR 450
    LFANIKPSKI LHPHKLISNY 470
    Length:470
    Mass (Da):54,039
    Last modified:June 6, 2002 - v2
    Checksum:i8908B49D15173DF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080362 Genomic DNA. Translation: CCD63173.1.
    PIRiH88473.
    RefSeqiNP_741165.1. NM_171144.4.
    UniGeneiCel.10889.

    Genome annotation databases

    EnsemblMetazoaiC05D10.2a; C05D10.2a; WBGene00015478.
    GeneIDi175857.
    KEGGicel:CELE_C05D10.2.
    UCSCiC05D10.2c. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080362 Genomic DNA. Translation: CCD63173.1 .
    PIRi H88473.
    RefSeqi NP_741165.1. NM_171144.4.
    UniGenei Cel.10889.

    3D structure databases

    ProteinModelPortali Q11179.
    SMRi Q11179. Positions 5-361.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q11179.
    PRIDEi Q11179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C05D10.2a ; C05D10.2a ; WBGene00015478 .
    GeneIDi 175857.
    KEGGi cel:CELE_C05D10.2.
    UCSCi C05D10.2c. c. elegans.

    Organism-specific databases

    CTDi 175857.
    WormBasei C05D10.2a ; CE29020 ; WBGene00015478 .

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110881.
    HOGENOMi HOG000233024.
    InParanoidi Q11179.
    KOi K08293.
    OMAi CTVKLCD.
    PhylomeDBi Q11179.

    Enzyme and pathway databases

    SignaLinki Q11179.

    Miscellaneous databases

    NextBioi 889996.
    PROi Q11179.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiYPC2_CAEEL
    AccessioniPrimary (citable) accession number: Q11179
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3