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Q11179 (YPC2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative serine/threonine-protein kinase C05D10.2

EC=2.7.11.24
Gene names
ORF Names:C05D10.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Putative serine/threonine-protein kinase C05D10.2
PRO_0000186307

Regions

Domain13 – 306294Protein kinase
Nucleotide binding19 – 279ATP By similarity
Motif178 – 1803TXY

Sites

Active site1371Proton acceptor By similarity
Binding site421ATP By similarity

Amino acid modifications

Modified residue1781Phosphothreonine By similarity
Modified residue1801Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q11179 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 8908B49D15173DF0

FASTA47054,039
        10         20         30         40         50         60 
MTDDVDTHIH EKFDLQKRLG KGAYGIVWKA YDKRSRETVA LKKIFDAFRN PTDSQRTFRE 

        70         80         90        100        110        120 
VMFLQEFGKH PNVIKLYNIF RADNDRDIYL AFEFMEADLH NVIKKGSILK DVHKQYIMCQ 

       130        140        150        160        170        180 
LFRAIRFLHS GNVLHRDLKP SNVLLDADCR VKLADFGLAR SLSSLEDYPE GQKMPDLTEY 

       190        200        210        220        230        240 
VATRWYRSPE ILLAAKRYTK GVDMWSLGCI LAEMLIGRAL FPGSSTINQI ERIMNTIAKP 

       250        260        270        280        290        300 
SRADIASIGS HYAASVLEKM PQRPRKPLDL IITQSQTAAI DMVQRLLIFA PQKRLTVEQC 

       310        320        330        340        350        360 
LVHPYVVQFH NPSEEPVLNY EVYPPLPDHI QLSIDDYRDR LYEMIDEKKA SFKRIQHEKI 

       370        380        390        400        410        420 
RPYGEDKSRA PIAQAECSDT DYDTARSLQR TTSMDKNNSS SHDSSSGTLR ERAASAESRT 

       430        440        450        460        470 
SKDSNGEMRN GNGNTPSSIK QRRRSVERAR LFANIKPSKI LHPHKLISNY 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080362 Genomic DNA. Translation: CCD63173.1.
PIRH88473.
RefSeqNP_741165.1. NM_171144.4.
UniGeneCel.10889.

3D structure databases

ProteinModelPortalQ11179.
SMRQ11179. Positions 5-361.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ11179.
PRIDEQ11179.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC05D10.2a; C05D10.2a; WBGene00015478.
GeneID175857.
KEGGcel:CELE_C05D10.2.
UCSCC05D10.2c. c. elegans.

Organism-specific databases

CTD175857.
WormBaseC05D10.2a; CE29020; WBGene00015478.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110881.
HOGENOMHOG000233024.
InParanoidQ11179.
KOK08293.
OMACTVKLCD.
PhylomeDBQ11179.

Enzyme and pathway databases

SignaLinkQ11179.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio889996.
PROQ11179.

Entry information

Entry nameYPC2_CAEEL
AccessionPrimary (citable) accession number: Q11179
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 6, 2002
Last modified: June 11, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase