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Protein

Probable endochitinase

Gene

cht-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791Proton donorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • chitin catabolic process Source: GO_Central
  • polysaccharide catabolic process Source: UniProtKB-KW
  • response to fungus Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Keywords - Ligandi

Chitin-binding

Enzyme and pathway databases

ReactomeiR-CEL-71387. Metabolism of carbohydrates.

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.
GH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endochitinase (EC:3.2.1.14)
Gene namesi
Name:cht-1
ORF Names:C04F6.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC04F6.3; CE03923; WBGene00000503; cht-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Probable endochitinasePRO_0000077049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi310 – 3101N-linked (GlcNAc...)2 Publications
Disulfide bondi511 ↔ 524PROSITE-ProRule annotation
Disulfide bondi594 ↔ 607PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ11174.

Expressioni

Gene expression databases

BgeeiWBGene00000503.

Interactioni

Protein-protein interaction databases

STRINGi6239.C04F6.3.1.

Structurei

3D structure databases

ProteinModelPortaliQ11174.
SMRiQ11174. Positions 57-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini478 – 53457Chitin-binding type-2 1PROSITE-ProRule annotationAdd
BLAST
Domaini563 – 61755Chitin-binding type-2 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi435 – 47844Thr-richAdd
BLAST

Sequence similaritiesi

Contains 2 chitin-binding type-2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOGENOMiHOG000111109.
InParanoidiQ11174.
KOiK01183.
OMAiEESFANK.
OrthoDBiEOG091G014W.
PhylomeDBiQ11174.

Family and domain databases

Gene3Di2.170.140.10. 2 hits.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR002557. Chitin-bd_dom.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01607. CBM_14. 2 hits.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00494. ChtBD2. 2 hits.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
SSF57625. SSF57625. 2 hits.
PROSITEiPS50940. CHIT_BIND_II. 2 hits.
PS01095. CHITINASE_18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGKFLLVA SFILPIAYTW TGATIRNHPA DVVAARNKIT SRSVARSEPT
60 70 80 90 100
NSYIRPCYFT NWAQYRQGRA KFVPEDYTPG LCTHILFAFG WMNADYTVRA
110 120 130 140 150
YDPADLPNDW AGEGMYRRVN KLKVTDTQLK TLLSFGGWSF GTALFQGMAA
160 170 180 190 200
SSASRKVFID SAITFVRTWG FDGIDIDWEY PSGATDMANY VALVKELKAA
210 220 230 240 250
CESEAGSTGK DRLLVTAAVA AGPATIDAGY DIPNLAPNFD FILLMSYDFF
260 270 280 290 300
GAWASLVGFN SPLYATTELP AEWNGWNVDS SARYWNQKGM PKEKIIVGMP
310 320 330 340 350
TYGRGWTLNN ASAINPGTSG SPAKITQYVQ EAGVGAYFEF CEMLANGATR
360 370 380 390 400
YWDSQSQVPY LVQGNQWWSY DDEESFANKM AYVKREGYGG AFVWTLDFDD
410 420 430 440 450
FNAGCSNSNG QLYPLISVIA KELGGVIIPK KGGVTTAPTT VATTVTTGRP
460 470 480 490 500
PMTSAVTTTT AATTTTTRAA TTTTASNTNV CSGKSDGFYP NSNNCGLFVL
510 520 530 540 550
CLSSKSYSMS CPSGLQYSAS LKYCTTSTAS GCSVTTTRAP TTTTKSAPTV
560 570 580 590 600
TTTTRAPTTT TPAFKCTKDG FFGVPSDCLK FIRCVNGISY NFECPNGLSF
610
HADTMMCDRP DPSKCAK
Length:617
Mass (Da):66,857
Last modified:November 1, 1997 - v1
Checksum:iDDA1D2AAAC0E54DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381W → C in AAB81847 (PubMed:9662472).Curated
Sequence conflicti163 – 1653ITF → TTS in AAB81847 (PubMed:9662472).Curated
Sequence conflicti176 – 1761I → L in AAB81847 (PubMed:9662472).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080344 Genomic DNA. Translation: CCD63028.1.
AF026152 Genomic DNA. Translation: AAB81847.1.
PIRiT15408.
T37249.
RefSeqiNP_508588.1. NM_076187.4.
UniGeneiCel.17326.

Genome annotation databases

EnsemblMetazoaiC04F6.3; C04F6.3; WBGene00000503.
GeneIDi180628.
KEGGicel:CELE_C04F6.3.
UCSCiC04F6.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080344 Genomic DNA. Translation: CCD63028.1.
AF026152 Genomic DNA. Translation: AAB81847.1.
PIRiT15408.
T37249.
RefSeqiNP_508588.1. NM_076187.4.
UniGeneiCel.17326.

3D structure databases

ProteinModelPortaliQ11174.
SMRiQ11174. Positions 57-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C04F6.3.1.

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.
GH18. Glycoside Hydrolase Family 18.

Proteomic databases

PaxDbiQ11174.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC04F6.3; C04F6.3; WBGene00000503.
GeneIDi180628.
KEGGicel:CELE_C04F6.3.
UCSCiC04F6.3.1. c. elegans.

Organism-specific databases

CTDi180628.
WormBaseiC04F6.3; CE03923; WBGene00000503; cht-1.

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOGENOMiHOG000111109.
InParanoidiQ11174.
KOiK01183.
OMAiEESFANK.
OrthoDBiEOG091G014W.
PhylomeDBiQ11174.

Enzyme and pathway databases

ReactomeiR-CEL-71387. Metabolism of carbohydrates.

Miscellaneous databases

PROiQ11174.

Gene expression databases

BgeeiWBGene00000503.

Family and domain databases

Gene3Di2.170.140.10. 2 hits.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR002557. Chitin-bd_dom.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01607. CBM_14. 2 hits.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00494. ChtBD2. 2 hits.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
SSF57625. SSF57625. 2 hits.
PROSITEiPS50940. CHIT_BIND_II. 2 hits.
PS01095. CHITINASE_18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHIT_CAEEL
AccessioniPrimary (citable) accession number: Q11174
Secondary accession number(s): O17321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.