##gff-version 3
Q11130	UniProtKB	Chain	1	342	.	.	.	ID=PRO_0000221113;Note=Alpha-(1%2C3)-fucosyltransferase 7	
Q11130	UniProtKB	Topological domain	1	14	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q11130	UniProtKB	Transmembrane	15	36	.	.	.	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q11130	UniProtKB	Topological domain	37	342	.	.	.	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q11130	UniProtKB	Glycosylation	81	81	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15926890;Dbxref=PMID:15926890	
Q11130	UniProtKB	Glycosylation	291	291	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15926890;Dbxref=PMID:15926890	
Q11130	UniProtKB	Disulfide bond	68	76	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11425803;Dbxref=PMID:11425803	
Q11130	UniProtKB	Disulfide bond	211	214	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11425803;Dbxref=PMID:11425803	
Q11130	UniProtKB	Disulfide bond	318	321	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11425803;Dbxref=PMID:11425803	
Q11130	UniProtKB	Natural variant	110	110	.	.	.	ID=VAR_079131;Note=Found in patients with ulcerative colitis%3B loss of alpha-(1%2C3)-fucosyltransferase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11404359;Dbxref=dbSNP:rs545570871,PMID:11404359	
Q11130	UniProtKB	Mutagenesis	81	81	.	.	.	Note=Impairs glycosylation. Impairs glycosylation%3B when associated with Q-291. Does not affect SELP and SELL binding on SELPLG. Does not affect SELP and SELL binding on SELPLG%3B when associated with Q-291. Abolishes alpha-(1%2C3)-fucosyltransferase activity. Abolishes alpha-(1%2C3)-fucosyltransferase activity%3B when associated with Q-291. Fails to synthetises sLe(x) antigens or to generate SELE binding. Fails to synthetises sLe(x) antigens or to generate SELE binding%3B when associated with Q-291. Does not affect sLe(x) antigens synthesis or SELE binding only in presence of SELPLG and GCNT1%3B when associated with Q-291. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15926890;Dbxref=PMID:15926890	
Q11130	UniProtKB	Mutagenesis	291	291	.	.	.	Note=Slightly affects glycosylation. Impairs glycosylation%3B when associated with Q-81. Does not affect SELP and SELL binding on SELPLG. Does not affect SELP and SELL binding on SELPLG%3B when associated with Q-81. Abolishes alpha-(1%2C3)-fucosyltransferase activity. Abolishes alpha-(1%2C3)-fucosyltransferase activity%3B when associated with Q-81. Fails to synthetises sLe(x) antigens or to generate SELE binding. Fails to synthetises sLe(x) antigens or to generate SELE binding%3B when associated with Q-81. Does not affect sLe(x) antigens synthesis or SELE binding only in presence of SELPLG and GCNT1%3B when associated with Q-81. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15926890;Dbxref=PMID:15926890	
Q11130	UniProtKB	Sequence conflict	161	162	.	.	.	Note=GP->A;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q11130	UniProtKB	Sequence conflict	304	305	.	.	.	Note=RL->SV;Ontology_term=ECO:0000305;evidence=ECO:0000305