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Protein

Alpha-(1,3)-fucosyltransferase 7

Gene

FUT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.3 Publications

Catalytic activityi

GDP-L-fucose + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-R.3 Publications

Kineticsi

  1. KM=5 µM for GDP-fucose1 Publication

    Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    GO - Molecular functioni

    • alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
    • fucosyltransferase activity Source: UniProtKB

    GO - Biological processi

    • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Source: Ensembl
    • ceramide metabolic process Source: BHF-UCL
    • leukocyte migration involved in immune response Source: Ensembl
    • L-fucose catabolic process Source: UniProtKB
    • protein glycosylation Source: UniProtKB

    Keywordsi

    Molecular functionGlycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMetaCyc:HS11506-MONOMER
    BRENDAi2.4.1.214 2681
    2.4.1.65 2681
    SABIO-RKiQ11130
    UniPathwayiUPA00378

    Protein family/group databases

    CAZyiGT10 Glycosyltransferase Family 10

    Chemistry databases

    SwissLipidsiSLP:000001438

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 7 (EC:2.4.1.-2 Publications)
    Alternative name(s):
    Fucosyltransferase 7
    Fucosyltransferase VII1 Publication
    Short name:
    Fuc-TVII1 Publication
    Short name:
    FucT-VII
    Galactoside 3-L-fucosyltransferase
    Selectin ligand synthase
    Gene namesi
    Name:FUT7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 9

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000180549.7
    HGNCiHGNC:4018 FUT7
    MIMi602030 gene
    neXtProtiNX_Q11130

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
    Transmembranei15 – 36Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
    Topological domaini37 – 342LumenalSequence analysisAdd BLAST306

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi2529
    OpenTargetsiENSG00000180549
    PharmGKBiPA28434

    Chemistry databases

    ChEMBLiCHEMBL3596077

    Polymorphism and mutation databases

    BioMutaiFUT7

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002211131 – 342Alpha-(1,3)-fucosyltransferase 7Add BLAST342

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Disulfide bondi68 ↔ 761 Publication
    Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi211 ↔ 2141 Publication
    Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi318 ↔ 3211 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ11130
    PeptideAtlasiQ11130
    PRIDEiQ11130

    PTM databases

    iPTMnetiQ11130
    PhosphoSitePlusiQ11130

    Expressioni

    Tissue specificityi

    Leukocytic/myeloid lineage cells.

    Gene expression databases

    BgeeiENSG00000180549
    CleanExiHS_FUT7
    GenevisibleiQ11130 HS

    Organism-specific databases

    HPAiHPA042780

    Interactioni

    Protein-protein interaction databases

    BioGridi108805, 3 interactors
    IntActiQ11130, 2 interactors
    STRINGi9606.ENSP00000318142

    Chemistry databases

    BindingDBiQ11130

    Structurei

    3D structure databases

    ProteinModelPortaliQ11130
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG2619 Eukaryota
    ENOG410ZIMX LUCA
    GeneTreeiENSGT00680000099679
    HOGENOMiHOG000045583
    HOVERGENiHBG000274
    InParanoidiQ11130
    KOiK07635
    OMAiHTHGLSH
    OrthoDBiEOG091G0846
    PhylomeDBiQ11130
    TreeFamiTF316348

    Family and domain databases

    Gene3Di3.40.50.11660, 1 hit
    InterProiView protein in InterPro
    IPR031481 Glyco_tran_10_N
    IPR001503 Glyco_trans_10
    IPR038577 GT10-like_sf
    PANTHERiPTHR11929 PTHR11929, 1 hit
    PfamiView protein in Pfam
    PF17039 Glyco_tran_10_N, 1 hit
    PF00852 Glyco_transf_10, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q11130-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MNNAGHGPTR RLRGLGVLAG VALLAALWLL WLLGSAPRGT PAPQPTITIL
    60 70 80 90 100
    VWHWPFTDQP PELPSDTCTR YGIARCHLSA NRSLLASADA VVFHHRELQT
    110 120 130 140 150
    RRSHLPLAQR PRGQPWVWAS MESPSHTHGL SHLRGIFNWV LSYRRDSDIF
    160 170 180 190 200
    VPYGRLEPHW GPSPPLPAKS RVAAWVVSNF QERQLRARLY RQLAPHLRVD
    210 220 230 240 250
    VFGRANGRPL CASCLVPTVA QYRFYLSFEN SQHRDYITEK FWRNALVAGT
    260 270 280 290 300
    VPVVLGPPRA TYEAFVPADA FVHVDDFGSA RELAAFLTGM NESRYQRFFA
    310 320 330 340
    WRDRLRVRLF TDWRERFCAI CDRYPHLPRS QVYEDLEGWF QA
    Length:342
    Mass (Da):39,239
    Last modified:October 1, 1996 - v1
    Checksum:iD31BFF90DD64DFAB
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti161 – 162GP → A in AAA56869 (PubMed:8207002).Curated2
    Sequence conflicti304 – 305RL → SV in AAA56869 (PubMed:8207002).Curated2

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_079131110R → Q Found in patients with ulcerative colitis; loss of alpha-(1,3)-fucosyltransferase activity. 1 PublicationCorresponds to variant dbSNP:rs545570871Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X78031 mRNA Translation: CAA54962.1
    U11282 mRNA Translation: AAA20468.1
    U08112 mRNA Translation: AAA56869.1
    AB012668 Genomic DNA Translation: BAA32819.1
    AK313124 mRNA Translation: BAG35944.1
    AL807752 Genomic DNA No translation available.
    BC074746 mRNA Translation: AAH74746.2
    BC086312 mRNA Translation: AAH86312.1
    CCDSiCCDS7022.1
    PIRiA54057
    RefSeqiNP_004470.1, NM_004479.3
    UniGeneiHs.457

    Genome annotation databases

    EnsembliENST00000314412; ENSP00000318142; ENSG00000180549
    GeneIDi2529
    KEGGihsa:2529
    UCSCiuc004ckq.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiFUT7_HUMAN
    AccessioniPrimary (citable) accession number: Q11130
    Secondary accession number(s): B2R7U7, Q6DK54
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: March 28, 2018
    This is version 156 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

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