Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-(1,3)-fucosyltransferase 7

Gene

FUT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.3 Publications

Catalytic activityi

GDP-L-fucose + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-R.3 Publications

Kineticsi

  1. KM=5 µM for GDP-fucose1 Publication

    Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    GO - Molecular functioni

    • alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
    • fucosyltransferase activity Source: UniProtKB

    GO - Biological processi

    • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Source: Ensembl
    • ceramide metabolic process Source: BHF-UCL
    • leukocyte migration involved in immune response Source: Ensembl
    • L-fucose catabolic process Source: UniProtKB
    • protein glycosylation Source: UniProtKB

    Keywordsi

    Molecular functionGlycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.214. 2681.
    2.4.1.65. 2681.
    SABIO-RKiQ11130.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT10. Glycosyltransferase Family 10.

    Chemistry databases

    SwissLipidsiSLP:000001438.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 7 (EC:2.4.1.-2 Publications)
    Alternative name(s):
    Fucosyltransferase 7
    Fucosyltransferase VII1 Publication
    Short name:
    Fuc-TVII1 Publication
    Short name:
    FucT-VII
    Galactoside 3-L-fucosyltransferase
    Selectin ligand synthase
    Gene namesi
    Name:FUT7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 9

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000180549.7.
    HGNCiHGNC:4018. FUT7.

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
    Transmembranei15 – 36Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
    Topological domaini37 – 342LumenalSequence analysisAdd BLAST306

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi2529.
    OpenTargetsiENSG00000180549.
    PharmGKBiPA28434.

    Chemistry databases

    ChEMBLiCHEMBL3596077.

    Polymorphism and mutation databases

    BioMutaiFUT7.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002211131 – 342Alpha-(1,3)-fucosyltransferase 7Add BLAST342

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Disulfide bondi68 ↔ 761 Publication
    Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi211 ↔ 2141 Publication
    Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi318 ↔ 3211 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ11130.
    PeptideAtlasiQ11130.
    PRIDEiQ11130.

    PTM databases

    iPTMnetiQ11130.
    PhosphoSitePlusiQ11130.

    Expressioni

    Tissue specificityi

    Leukocytic/myeloid lineage cells.

    Gene expression databases

    BgeeiENSG00000180549.
    CleanExiHS_FUT7.
    GenevisibleiQ11130. HS.

    Organism-specific databases

    HPAiHPA042780.

    Interactioni

    Protein-protein interaction databases

    BioGridi108805. 3 interactors.
    IntActiQ11130. 2 interactors.
    STRINGi9606.ENSP00000318142.

    Chemistry databases

    BindingDBiQ11130.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG2619. Eukaryota.
    ENOG410ZIMX. LUCA.
    GeneTreeiENSGT00680000099679.
    HOGENOMiHOG000045583.
    HOVERGENiHBG000274.
    InParanoidiQ11130.
    KOiK07635.
    OMAiHTHGLSH.
    OrthoDBiEOG091G0846.
    PhylomeDBiQ11130.
    TreeFamiTF316348.

    Family and domain databases

    InterProiView protein in InterPro
    IPR031481. Glyco_tran_10_N.
    IPR001503. Glyco_trans_10.
    PANTHERiPTHR11929. PTHR11929. 1 hit.
    PfamiView protein in Pfam
    PF17039. Glyco_tran_10_N. 1 hit.
    PF00852. Glyco_transf_10. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q11130-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MNNAGHGPTR RLRGLGVLAG VALLAALWLL WLLGSAPRGT PAPQPTITIL
    60 70 80 90 100
    VWHWPFTDQP PELPSDTCTR YGIARCHLSA NRSLLASADA VVFHHRELQT
    110 120 130 140 150
    RRSHLPLAQR PRGQPWVWAS MESPSHTHGL SHLRGIFNWV LSYRRDSDIF
    160 170 180 190 200
    VPYGRLEPHW GPSPPLPAKS RVAAWVVSNF QERQLRARLY RQLAPHLRVD
    210 220 230 240 250
    VFGRANGRPL CASCLVPTVA QYRFYLSFEN SQHRDYITEK FWRNALVAGT
    260 270 280 290 300
    VPVVLGPPRA TYEAFVPADA FVHVDDFGSA RELAAFLTGM NESRYQRFFA
    310 320 330 340
    WRDRLRVRLF TDWRERFCAI CDRYPHLPRS QVYEDLEGWF QA
    Length:342
    Mass (Da):39,239
    Last modified:October 1, 1996 - v1
    Checksum:iD31BFF90DD64DFAB
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti161 – 162GP → A in AAA56869 (PubMed:8207002).Curated2
    Sequence conflicti304 – 305RL → SV in AAA56869 (PubMed:8207002).Curated2

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_079131110R → Q Found in patients with ulcerative colitis; loss of alpha-(1,3)-fucosyltransferase activity. 1 Publication1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X78031 mRNA. Translation: CAA54962.1.
    U11282 mRNA. Translation: AAA20468.1.
    U08112 mRNA. Translation: AAA56869.1.
    AB012668 Genomic DNA. Translation: BAA32819.1.
    AK313124 mRNA. Translation: BAG35944.1.
    AL807752 Genomic DNA. No translation available.
    BC074746 mRNA. Translation: AAH74746.2.
    BC086312 mRNA. Translation: AAH86312.1.
    CCDSiCCDS7022.1.
    PIRiA54057.
    RefSeqiNP_004470.1. NM_004479.3.
    UniGeneiHs.457.

    Genome annotation databases

    EnsembliENST00000314412; ENSP00000318142; ENSG00000180549.
    GeneIDi2529.
    KEGGihsa:2529.
    UCSCiuc004ckq.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiFUT7_HUMAN
    AccessioniPrimary (citable) accession number: Q11130
    Secondary accession number(s): B2R7U7, Q6DK54
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 25, 2017
    This is version 153 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families