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Q11130 (FUT7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-(1,3)-fucosyltransferase 7

EC=2.4.1.-
Alternative name(s):
Fucosyltransferase 7
Fucosyltransferase VII
Short name=Fuc-TVII
Short name=FucT-VII
Galactoside 3-L-fucosyltransferase
Selectin ligand synthase
Gene names
Name:FUT7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.

Catalytic activity

GDP-L-fucose + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-R.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein. Note: Membrane-bound form in trans cisternae of Golgi.

Tissue specificity

Leukocytic/myeloid lineage cells.

Sequence similarities

Belongs to the glycosyltransferase 10 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Alpha-(1,3)-fucosyltransferase 7
PRO_0000221113

Regions

Topological domain1 – 1414Cytoplasmic Potential
Transmembrane15 – 3622Helical; Signal-anchor for type II membrane protein; Potential
Topological domain37 – 342306Lumenal Potential

Amino acid modifications

Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Disulfide bond68 ↔ 76 Ref.8
Disulfide bond211 ↔ 214 Ref.8
Disulfide bond318 ↔ 321 Ref.8

Experimental info

Sequence conflict161 – 1622GP → A in AAA56869. Ref.1
Sequence conflict304 – 3052RL → SV in AAA56869. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q11130 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D31BFF90DD64DFAB

FASTA34239,239
        10         20         30         40         50         60 
MNNAGHGPTR RLRGLGVLAG VALLAALWLL WLLGSAPRGT PAPQPTITIL VWHWPFTDQP 

        70         80         90        100        110        120 
PELPSDTCTR YGIARCHLSA NRSLLASADA VVFHHRELQT RRSHLPLAQR PRGQPWVWAS 

       130        140        150        160        170        180 
MESPSHTHGL SHLRGIFNWV LSYRRDSDIF VPYGRLEPHW GPSPPLPAKS RVAAWVVSNF 

       190        200        210        220        230        240 
QERQLRARLY RQLAPHLRVD VFGRANGRPL CASCLVPTVA QYRFYLSFEN SQHRDYITEK 

       250        260        270        280        290        300 
FWRNALVAGT VPVVLGPPRA TYEAFVPADA FVHVDDFGSA RELAAFLTGM NESRYQRFFA 

       310        320        330        340 
WRDRLRVRLF TDWRERFCAI CDRYPHLPRS QVYEDLEGWF QA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant."
Natsuka S., Gersten K.M., Zenita K., Kannagi R., Lowe J.B.
J. Biol. Chem. 269:16789-16794(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant."
Natsuka S., Gersten K.M., Zenita K., Kannagi R., Lowe J.B.
J. Biol. Chem. 269:20806-20806(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes."
Sasaki K., Kurata K., Funayama K., Nagata M., Watanabe E., Ohta S., Hanai N., Nishi T.
J. Biol. Chem. 269:14730-14737(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The human selectin-ligand synthase (hFuc-T VII) gene structure and characterization of the promoter."
Hiraiwa N., Hiraiwa M., Kannagi R.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[6]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Mammary gland.
[8]"Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures."
de Vries T., Yen T.Y., Joshi R.K., Storm J., van Den Eijnden D.H., Knegtel R.M.A., Bunschoten H., Joziasse D.H., Macher B.A.
Glycobiology 11:423-432(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
+Additional computationally mapped references.

Web resources

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Fucosyltransferase 7

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78031 mRNA. Translation: CAA54962.1.
U11282 mRNA. Translation: AAA20468.1.
U08112 mRNA. Translation: AAA56869.1.
AB012668 Genomic DNA. Translation: BAA32819.1.
AK313124 mRNA. Translation: BAG35944.1.
AL807752 Genomic DNA. Translation: CAI12771.1.
BC074746 mRNA. Translation: AAH74746.2.
BC086312 mRNA. Translation: AAH86312.1.
CCDSCCDS7022.1.
PIRA54057.
RefSeqNP_004470.1. NM_004479.3.
UniGeneHs.457.

3D structure databases

ProteinModelPortalQ11130.
SMRQ11130. Positions 167-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108805. 1 interaction.
STRING9606.ENSP00000318142.

Protein family/group databases

CAZyGT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSiteQ11130.

Proteomic databases

PaxDbQ11130.
PRIDEQ11130.

Protocols and materials databases

DNASU2529.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314412; ENSP00000318142; ENSG00000180549.
GeneID2529.
KEGGhsa:2529.
UCSCuc004ckq.2. human.

Organism-specific databases

CTD2529.
GeneCardsGC09M139924.
HGNCHGNC:4018. FUT7.
MIM602030. gene.
neXtProtNX_Q11130.
PharmGKBPA28434.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG252779.
HOGENOMHOG000045583.
HOVERGENHBG000274.
InParanoidQ11130.
KOK07635.
OMAGAMDSAN.
OrthoDBEOG7Z69C9.
PhylomeDBQ11130.
TreeFamTF316348.

Enzyme and pathway databases

BRENDA2.4.1.65. 2681.
UniPathwayUPA00378.

Gene expression databases

BgeeQ11130.
CleanExHS_FUT7.
GenevestigatorQ11130.

Family and domain databases

InterProIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERPTHR11929. PTHR11929. 1 hit.
PfamPF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFUT7.
GenomeRNAi2529.
NextBio9967.
PROQ11130.
SOURCESearch...

Entry information

Entry nameFUT7_HUMAN
AccessionPrimary (citable) accession number: Q11130
Secondary accession number(s): B2R7U7, Q6DK54
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM