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Q11128

- FUT5_HUMAN

UniProt

Q11128 - FUT5_HUMAN

Protein

Alpha-(1,3)-fucosyltransferase 5

Gene

FUT5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

    Catalytic activityi

    GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.

    Pathwayi

    GO - Molecular functioni

    1. 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Source: UniProtKB-EC
    2. alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
    3. fucosyltransferase activity Source: ProtInc

    GO - Biological processi

    1. carbohydrate metabolic process Source: ProtInc
    2. fucosylation Source: GOC
    3. L-fucose catabolic process Source: UniProtKB
    4. protein glycosylation Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.65. 2681.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT10. Glycosyltransferase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 5 (EC:2.4.1.65)
    Alternative name(s):
    Fucosyltransferase 5
    Fucosyltransferase V
    Short name:
    Fuc-TV
    Short name:
    FucT-V
    Galactoside 3-L-fucosyltransferase
    Gene namesi
    Name:FUT5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4016. FUT5.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein
    Note: Membrane-bound form in trans cisternae of Golgi.

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi cisterna membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28432.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Alpha-(1,3)-fucosyltransferase 5PRO_0000221105Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ11128.
    PaxDbiQ11128.
    PRIDEiQ11128.

    PTM databases

    PhosphoSiteiQ11128.

    Expressioni

    Tissue specificityi

    Liver, colon and testis and trace amounts in T-cells and brain.

    Gene expression databases

    BgeeiQ11128.
    CleanExiHS_FUT5.
    GenevestigatoriQ11128.

    Organism-specific databases

    HPAiHPA046966.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000252675.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11128.
    SMRiQ11128. Positions 200-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 374340LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3419Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283180.
    HOGENOMiHOG000045583.
    HOVERGENiHBG000274.
    InParanoidiQ11128.
    KOiK07633.
    PhylomeDBiQ11128.

    Family and domain databases

    InterProiIPR001503. Glyco_trans_10.
    [Graphical view]
    PANTHERiPTHR11929. PTHR11929. 1 hit.
    PfamiPF00852. Glyco_transf_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q11128-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPLGPAKPQ WLWRRCLAGL LFQLLVAVCF FSYLRVSRDD ATGSPRPGLM    50
    AVEPVTGAPN GSRCQDSMAT PAHPTLLILL WTWPFNTPVA LPRCSEMVPG 100
    AADCNITADS SVYPQADAVI VHHWDIMYNP SANLPPPTRP QGQRWIWFSM 150
    ESPSNCRHLE ALDGYFNLTM SYRSDSDIFT PYGWLEPWSG QPAHPPLNLS 200
    AKTELVAWAV SNWKPDSARV RYYQSLQAHL KVDVYGRSHK PLPKGTMMET 250
    LSRYKFYLAF ENSLHPDYIT EKLWRNALEA WAVPVVLGPS RSNYERFLPP 300
    DAFIHVDDFQ SPKDLARYLQ ELDKDHARYL SYFRWRETLR PRSFSWALAF 350
    CKACWKLQQE SRYQTVRSIA AWFT 374
    Length:374
    Mass (Da):43,008
    Last modified:October 1, 1996 - v1
    Checksum:iB825281521B57939
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti187 – 1871P → L.
    Corresponds to variant rs778970 [ dbSNP | Ensembl ].
    VAR_022122
    Natural varianti338 – 3381T → M.
    Corresponds to variant rs4807054 [ dbSNP | Ensembl ].
    VAR_055845

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81485 Genomic DNA. Translation: AAA98117.1.
    U27329 mRNA. Translation: AAC50188.1.
    U27330 mRNA. Translation: AAC50189.1.
    AK291087 mRNA. Translation: BAF83776.1.
    AC024592 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69134.1.
    BC140905 mRNA. Translation: AAI40906.1.
    CCDSiCCDS12154.1.
    PIRiA42270.
    RefSeqiNP_002025.2. NM_002034.2.
    UniGeneiHs.631843.

    Genome annotation databases

    EnsembliENST00000252675; ENSP00000252675; ENSG00000130383.
    GeneIDi2527.
    KEGGihsa:2527.
    UCSCiuc002mdo.4. human.

    Polymorphism databases

    DMDMi1730135.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    Fucosyltransferase 5

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81485 Genomic DNA. Translation: AAA98117.1 .
    U27329 mRNA. Translation: AAC50188.1 .
    U27330 mRNA. Translation: AAC50189.1 .
    AK291087 mRNA. Translation: BAF83776.1 .
    AC024592 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69134.1 .
    BC140905 mRNA. Translation: AAI40906.1 .
    CCDSi CCDS12154.1.
    PIRi A42270.
    RefSeqi NP_002025.2. NM_002034.2.
    UniGenei Hs.631843.

    3D structure databases

    ProteinModelPortali Q11128.
    SMRi Q11128. Positions 200-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000252675.

    Chemistry

    BindingDBi Q11128.
    ChEMBLi CHEMBL3146.

    Protein family/group databases

    CAZyi GT10. Glycosyltransferase Family 10.

    PTM databases

    PhosphoSitei Q11128.

    Polymorphism databases

    DMDMi 1730135.

    Proteomic databases

    MaxQBi Q11128.
    PaxDbi Q11128.
    PRIDEi Q11128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252675 ; ENSP00000252675 ; ENSG00000130383 .
    GeneIDi 2527.
    KEGGi hsa:2527.
    UCSCi uc002mdo.4. human.

    Organism-specific databases

    CTDi 2527.
    GeneCardsi GC19M005865.
    H-InvDB HIX0213024.
    HGNCi HGNC:4016. FUT5.
    HPAi HPA046966.
    MIMi 136835. gene.
    neXtProti NX_Q11128.
    PharmGKBi PA28432.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283180.
    HOGENOMi HOG000045583.
    HOVERGENi HBG000274.
    InParanoidi Q11128.
    KOi K07633.
    PhylomeDBi Q11128.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.1.65. 2681.

    Miscellaneous databases

    ChiTaRSi FUT5. human.
    GeneWikii FUT5.
    GenomeRNAii 2527.
    NextBioi 9957.
    PROi Q11128.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q11128.
    CleanExi HS_FUT5.
    Genevestigatori Q11128.

    Family and domain databases

    InterProi IPR001503. Glyco_trans_10.
    [Graphical view ]
    PANTHERi PTHR11929. PTHR11929. 1 hit.
    Pfami PF00852. Glyco_transf_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities."
      Weston B.W., Nair R.P., Larsen R.D., Lowe J.B.
      J. Biol. Chem. 267:4152-4160(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Peripheral blood leukocyte.
    2. "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms."
      Cameron H.S., Szczepaniak D., Weston B.W.
      J. Biol. Chem. 270:20112-20122(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon, Kidney and Liver.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiFUT5_HUMAN
    AccessioniPrimary (citable) accession number: Q11128
    Secondary accession number(s): A8K4X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3