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Protein

Alpha-(1,3)-fucosyltransferase 5

Gene

FUT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Source: UniProtKB-EC
  • alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
  • fucosyltransferase activity Source: BHF-UCL

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • ceramide metabolic process Source: BHF-UCL
  • L-fucose catabolic process Source: UniProtKB
  • protein glycosylation Source: UniProtKB

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.152. 2681.
2.4.1.65. 2681.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Chemistry databases

SwissLipidsiSLP:000001430.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 5 (EC:2.4.1.65)
Alternative name(s):
Fucosyltransferase 5
Fucosyltransferase V
Short name:
Fuc-TV
Short name:
FucT-V
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FUT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130383.7.
HGNCiHGNC:4016. FUT5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19
Topological domaini35 – 374LumenalSequence analysisAdd BLAST340

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2527.
PharmGKBiPA28432.

Chemistry databases

ChEMBLiCHEMBL3146.

Polymorphism and mutation databases

BioMutaiFUT5.
DMDMi1730135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211051 – 374Alpha-(1,3)-fucosyltransferase 5Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ11128.
PaxDbiQ11128.
PeptideAtlasiQ11128.
PRIDEiQ11128.

PTM databases

iPTMnetiQ11128.
PhosphoSitePlusiQ11128.

Expressioni

Tissue specificityi

Liver, colon and testis and trace amounts in T-cells and brain.

Gene expression databases

BgeeiENSG00000130383.
CleanExiHS_FUT5.
ExpressionAtlasiQ11128. baseline and differential.
GenevisibleiQ11128. HS.

Organism-specific databases

HPAiHPA046966.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252675.

Chemistry databases

BindingDBiQ11128.

Structurei

3D structure databases

ProteinModelPortaliQ11128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ11128.
KOiK07633.
OrthoDBiEOG091G0846.
PhylomeDBiQ11128.

Family and domain databases

InterProiView protein in InterPro
IPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiView protein in Pfam
PF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLGPAKPQ WLWRRCLAGL LFQLLVAVCF FSYLRVSRDD ATGSPRPGLM
60 70 80 90 100
AVEPVTGAPN GSRCQDSMAT PAHPTLLILL WTWPFNTPVA LPRCSEMVPG
110 120 130 140 150
AADCNITADS SVYPQADAVI VHHWDIMYNP SANLPPPTRP QGQRWIWFSM
160 170 180 190 200
ESPSNCRHLE ALDGYFNLTM SYRSDSDIFT PYGWLEPWSG QPAHPPLNLS
210 220 230 240 250
AKTELVAWAV SNWKPDSARV RYYQSLQAHL KVDVYGRSHK PLPKGTMMET
260 270 280 290 300
LSRYKFYLAF ENSLHPDYIT EKLWRNALEA WAVPVVLGPS RSNYERFLPP
310 320 330 340 350
DAFIHVDDFQ SPKDLARYLQ ELDKDHARYL SYFRWRETLR PRSFSWALAF
360 370
CKACWKLQQE SRYQTVRSIA AWFT
Length:374
Mass (Da):43,008
Last modified:October 1, 1996 - v1
Checksum:iB825281521B57939
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022122187P → L. Corresponds to variant dbSNP:rs778970Ensembl.1
Natural variantiVAR_055845338T → M. Corresponds to variant dbSNP:rs4807054Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81485 Genomic DNA. Translation: AAA98117.1.
U27329 mRNA. Translation: AAC50188.1.
U27330 mRNA. Translation: AAC50189.1.
AK291087 mRNA. Translation: BAF83776.1.
AC024592 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69134.1.
BC140905 mRNA. Translation: AAI40906.1.
CCDSiCCDS12154.1.
PIRiA42270.
RefSeqiNP_002025.2. NM_002034.2.
UniGeneiHs.631843.

Genome annotation databases

EnsembliENST00000252675; ENSP00000252675; ENSG00000130383.
GeneIDi2527.
KEGGihsa:2527.
UCSCiuc060sei.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFUT5_HUMAN
AccessioniPrimary (citable) accession number: Q11128
Secondary accession number(s): A8K4X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families