Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

Fut4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.152 3474
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 4
Fucosyltransferase IV
Short name:
Fuc-TIV
Short name:
FucT-IV
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut4
Synonyms:Elft
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:95594 Fut4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 74Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
Topological domaini75 – 433LumenalSequence analysisAdd BLAST359

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211011 – 433Alpha-(1,3)-fucosyltransferase 4Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ11127
PRIDEiQ11127

PTM databases

iPTMnetiQ11127
PhosphoSitePlusiQ11127

Expressioni

Tissue specificityi

Highest expression in stomach and colon. It is also expressed in the lung, testis, uterus, small intestine and to a lesser extent in spleen, and ovary. Present in trace amounts in brain, thymus, heart, smooth muscle, kidney and bone marrow. Not found in liver, salivary gland and pancreas.

Gene expression databases

BgeeiENSMUSG00000049307
CleanExiMM_FUT4
ExpressionAtlasiQ11127 baseline and differential
GenevisibleiQ11127 MM

Interactioni

Protein-protein interaction databases

IntActiQ11127, 1 interactor
STRINGi10090.ENSMUSP00000053027

Structurei

3D structure databases

ProteinModelPortaliQ11127
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00680000099679
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiQ11127
KOiK07632
OMAiCRLRFNI
OrthoDBiEOG091G0846
PhylomeDBiQ11127
TreeFamiTF316348

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q11127-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPARQELQH ESRCRPSRTV DAWRAAVATR GRHMETPGYR RRTRCGGWGL
60 70 80 90 100
PRSVSSLAAV GLLCTALTTF ICWGQLPPLP WASPAPQRLV GVLLWWEPFR
110 120 130 140 150
GRGGYPKSPP DCSLRFNISG CRLLTDRAAY GEAQAVLFHH RDLVKELHDW
160 170 180 190 200
PPPWGARERT DKALVLRVFD DQEGAVTLTG KALETVGSRP PGQRWVWMNF
210 220 230 240 250
ESPSHTPGLR GLAKDLFNWT LSYRTDSDVF VPYGFLYSRS DPTEQPSGLG
260 270 280 290 300
PQLARKRGLV AWVVSNWNEH QARVRYYHQL SRHVSVDVFG RTGPGRPVPA
310 320 330 340 350
IGLLHTVARY KFYLAFENSR HVDYITEKLW RNAFLAGAVP VVLGPDRANY
360 370 380 390 400
ERFVPRGAFI HVDDFPNAAS LAAYLLFLDR NVAVYRRYFR WRRSFAVHIT
410 420 430
SFWDEQWCRT CQAVQTSGDQ PKSIHNLADW FQR
Length:433
Mass (Da):49,481
Last modified:October 1, 1996 - v1
Checksum:i2401822F02B5D021
GO
Isoform Short (identifier: Q11127-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:400
Mass (Da):45,698
Checksum:iDD4E8BA7D2614B39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252Q → P in BAA09697 (PubMed:8882722).Curated1
Sequence conflicti257R → Q in BAA09697 (PubMed:8882722).Curated1
Sequence conflicti260V → E in BAA09697 (PubMed:8882722).Curated1
Sequence conflicti273R → Q in BAA09697 (PubMed:8882722).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0017781 – 33Missing in isoform Short. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33457 Genomic DNA Translation: AAC52269.1
D63380 Genomic DNA Translation: BAA09697.1
D63379 mRNA Translation: BAA09696.1
CCDSiCCDS22825.1 [Q11127-1]
PIRiA57596
RefSeqiNP_034372.1, NM_010242.3 [Q11127-1]
UniGeneiMm.63450

Genome annotation databases

EnsembliENSMUST00000061498; ENSMUSP00000053027; ENSMUSG00000049307 [Q11127-1]
GeneIDi14345
KEGGimmu:14345
UCSCiuc009oew.1 mouse [Q11127-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFUT4_MOUSE
AccessioniPrimary (citable) accession number: Q11127
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health