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Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

Fut4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.152. 3474.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 4
Fucosyltransferase IV
Short name:
Fuc-TIV
Short name:
FucT-IV
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut4
Synonyms:Elft
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:95594. Fut4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7422Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini75 – 433359LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell periphery Source: MGI
  • cell surface Source: MGI
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Alpha-(1,3)-fucosyltransferase 4PRO_0000221101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ11127.
PaxDbiQ11127.
PRIDEiQ11127.

PTM databases

PhosphoSiteiQ11127.

Expressioni

Tissue specificityi

Highest expression in stomach and colon. It is also expressed in the lung, testis, uterus, small intestine and to a lesser extent in spleen, and ovary. Present in trace amounts in brain, thymus, heart, smooth muscle, kidney and bone marrow. Not found in liver, salivary gland and pancreas.

Gene expression databases

BgeeiENSMUSG00000049307.
CleanExiMM_FUT4.
ExpressionAtlasiQ11127. baseline and differential.
GenevisibleiQ11127. MM.

Interactioni

Protein-protein interaction databases

IntActiQ11127. 1 interaction.
STRINGi10090.ENSMUSP00000053027.

Structurei

3D structure databases

ProteinModelPortaliQ11127.
SMRiQ11127. Positions 255-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ11127.
KOiK07632.
OMAiFHWRRRY.
OrthoDBiEOG091G0846.
PhylomeDBiQ11127.
TreeFamiTF316348.

Family and domain databases

InterProiIPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 2 hits.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q11127-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPARQELQH ESRCRPSRTV DAWRAAVATR GRHMETPGYR RRTRCGGWGL
60 70 80 90 100
PRSVSSLAAV GLLCTALTTF ICWGQLPPLP WASPAPQRLV GVLLWWEPFR
110 120 130 140 150
GRGGYPKSPP DCSLRFNISG CRLLTDRAAY GEAQAVLFHH RDLVKELHDW
160 170 180 190 200
PPPWGARERT DKALVLRVFD DQEGAVTLTG KALETVGSRP PGQRWVWMNF
210 220 230 240 250
ESPSHTPGLR GLAKDLFNWT LSYRTDSDVF VPYGFLYSRS DPTEQPSGLG
260 270 280 290 300
PQLARKRGLV AWVVSNWNEH QARVRYYHQL SRHVSVDVFG RTGPGRPVPA
310 320 330 340 350
IGLLHTVARY KFYLAFENSR HVDYITEKLW RNAFLAGAVP VVLGPDRANY
360 370 380 390 400
ERFVPRGAFI HVDDFPNAAS LAAYLLFLDR NVAVYRRYFR WRRSFAVHIT
410 420 430
SFWDEQWCRT CQAVQTSGDQ PKSIHNLADW FQR
Length:433
Mass (Da):49,481
Last modified:October 1, 1996 - v1
Checksum:i2401822F02B5D021
GO
Isoform Short (identifier: Q11127-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:400
Mass (Da):45,698
Checksum:iDD4E8BA7D2614B39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521Q → P in BAA09697 (PubMed:8882722).Curated
Sequence conflicti257 – 2571R → Q in BAA09697 (PubMed:8882722).Curated
Sequence conflicti260 – 2601V → E in BAA09697 (PubMed:8882722).Curated
Sequence conflicti273 – 2731R → Q in BAA09697 (PubMed:8882722).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3333Missing in isoform Short. 1 PublicationVSP_001778Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33457 Genomic DNA. Translation: AAC52269.1.
D63380 Genomic DNA. Translation: BAA09697.1.
D63379 mRNA. Translation: BAA09696.1.
CCDSiCCDS22825.1. [Q11127-1]
PIRiA57596.
RefSeqiNP_034372.1. NM_010242.3. [Q11127-1]
UniGeneiMm.63450.

Genome annotation databases

EnsembliENSMUST00000061498; ENSMUSP00000053027; ENSMUSG00000049307. [Q11127-1]
GeneIDi14345.
KEGGimmu:14345.
UCSCiuc009oew.1. mouse. [Q11127-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33457 Genomic DNA. Translation: AAC52269.1.
D63380 Genomic DNA. Translation: BAA09697.1.
D63379 mRNA. Translation: BAA09696.1.
CCDSiCCDS22825.1. [Q11127-1]
PIRiA57596.
RefSeqiNP_034372.1. NM_010242.3. [Q11127-1]
UniGeneiMm.63450.

3D structure databases

ProteinModelPortaliQ11127.
SMRiQ11127. Positions 255-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ11127. 1 interaction.
STRINGi10090.ENSMUSP00000053027.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSiteiQ11127.

Proteomic databases

MaxQBiQ11127.
PaxDbiQ11127.
PRIDEiQ11127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061498; ENSMUSP00000053027; ENSMUSG00000049307. [Q11127-1]
GeneIDi14345.
KEGGimmu:14345.
UCSCiuc009oew.1. mouse. [Q11127-1]

Organism-specific databases

CTDi2526.
MGIiMGI:95594. Fut4.

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ11127.
KOiK07632.
OMAiFHWRRRY.
OrthoDBiEOG091G0846.
PhylomeDBiQ11127.
TreeFamiTF316348.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.152. 3474.

Miscellaneous databases

PROiQ11127.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049307.
CleanExiMM_FUT4.
ExpressionAtlasiQ11127. baseline and differential.
GenevisibleiQ11127. MM.

Family and domain databases

InterProiIPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 2 hits.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUT4_MOUSE
AccessioniPrimary (citable) accession number: Q11127
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.