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Protein

Lysophospholipase

Gene
N/A
Organism
Torulaspora delbrueckii (Yeast) (Candida colliculosa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
OrganismiTorulaspora delbrueckii (Yeast) (Candida colliculosa)
Taxonomic identifieri4950 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002464522 – 649LysophospholipaseAdd BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Glycosylationi343N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi487N-linked (GlcNAc...)Sequence analysis1
Glycosylationi511N-linked (GlcNAc...)Sequence analysis1
Glycosylationi539N-linked (GlcNAc...)Sequence analysis1
Glycosylationi563N-linked (GlcNAc...)Sequence analysis1
Glycosylationi580N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi4950.XP_003683005.1.

Structurei

3D structure databases

ProteinModelPortaliQ11121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 584PLA2cPROSITE-ProRule annotationAdd BLAST551

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi612 – 617Poly-Ser6

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1325. Eukaryota.
ENOG410XR72. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00022. PLAc. 1 hit.
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS51210. PLA2C. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q11121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLKEWLLFS DAVFFAQGTL AWSPSNSYTP ANVSCDEDIN LIRQASGPSD
60 70 80 90 100
NETEWLKKRD VYTREALRSF LDRATSNFSD SSLVSQLFSN ASDIPRIAVA
110 120 130 140 150
CSGGGYRAML SGAGMLAAMD NRTDGANEHG LGGLLQSTTY LAGLSGGNWL
160 170 180 190 200
VGTLAWNNWT SVQDIVNNMT EDDSIWDISN SIINPGGFMI VTTIKRWDHI
210 220 230 240 250
SDAVEGKQDA GFNVSLTDIW GRALSYNFFP SLYRGGVAYT WSTLRDVEVF
260 270 280 290 300
QNGEMPFPIS VADGRYPGTQ IIDLNATVFE FNPFEMGSWD PTLNAFTDVK
310 320 330 340 350
YLGTKVSNGE PVNKGQCVAG YDNTGFIMGT SSSLFNQFLL QINSTSLPSF
360 370 380 390 400
IKNLVTGFLD DLSEDEDDIA IYAPNPFKDT SYIQDNFSKS ISESDYLYLV
410 420 430 440 450
DGGEDNQNIP LVPLVQDERN VDVIFALDNS ADTDYYWPDG ASLVSTYERQ
460 470 480 490 500
FSSQGLNMSF PYVPDKRTFV NLGLADKPSF FGCDAQNLTD LNYIPPLVVY
510 520 530 540 550
IPNARHSYNS NTSTFKLSYT DDERLKMIKN GFEAATRGNL TDDSSFMGCV
560 570 580 590 600
ACAVMRRKQQ SLNATLPEEC STCFTNYCWN GTIDDTPVSG LDNSDFDPTA
610 620 630 640
ASSAYSAYNT ESYSSSSATG SKKNGAGLPA TPTSFTSILT LLTAIAGFL
Length:649
Mass (Da):71,111
Last modified:November 1, 1997 - v1
Checksum:iCC6901D168D01459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32134 Genomic DNA. Translation: BAA06860.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32134 Genomic DNA. Translation: BAA06860.1.

3D structure databases

ProteinModelPortaliQ11121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4950.XP_003683005.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1325. Eukaryota.
ENOG410XR72. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00022. PLAc. 1 hit.
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS51210. PLA2C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLB1_TORDE
AccessioniPrimary (citable) accession number: Q11121
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 15, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.