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Protein

Lysophospholipase

Gene
N/A
Organism
Torulaspora delbrueckii (Yeast) (Candida colliculosa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
OrganismiTorulaspora delbrueckii (Yeast) (Candida colliculosa)
Taxonomic identifieri4950 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 649628LysophospholipasePRO_0000024645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi539 – 5391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ11121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 584551PLA2cPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi612 – 6176Poly-Ser

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q11121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLKEWLLFS DAVFFAQGTL AWSPSNSYTP ANVSCDEDIN LIRQASGPSD
60 70 80 90 100
NETEWLKKRD VYTREALRSF LDRATSNFSD SSLVSQLFSN ASDIPRIAVA
110 120 130 140 150
CSGGGYRAML SGAGMLAAMD NRTDGANEHG LGGLLQSTTY LAGLSGGNWL
160 170 180 190 200
VGTLAWNNWT SVQDIVNNMT EDDSIWDISN SIINPGGFMI VTTIKRWDHI
210 220 230 240 250
SDAVEGKQDA GFNVSLTDIW GRALSYNFFP SLYRGGVAYT WSTLRDVEVF
260 270 280 290 300
QNGEMPFPIS VADGRYPGTQ IIDLNATVFE FNPFEMGSWD PTLNAFTDVK
310 320 330 340 350
YLGTKVSNGE PVNKGQCVAG YDNTGFIMGT SSSLFNQFLL QINSTSLPSF
360 370 380 390 400
IKNLVTGFLD DLSEDEDDIA IYAPNPFKDT SYIQDNFSKS ISESDYLYLV
410 420 430 440 450
DGGEDNQNIP LVPLVQDERN VDVIFALDNS ADTDYYWPDG ASLVSTYERQ
460 470 480 490 500
FSSQGLNMSF PYVPDKRTFV NLGLADKPSF FGCDAQNLTD LNYIPPLVVY
510 520 530 540 550
IPNARHSYNS NTSTFKLSYT DDERLKMIKN GFEAATRGNL TDDSSFMGCV
560 570 580 590 600
ACAVMRRKQQ SLNATLPEEC STCFTNYCWN GTIDDTPVSG LDNSDFDPTA
610 620 630 640
ASSAYSAYNT ESYSSSSATG SKKNGAGLPA TPTSFTSILT LLTAIAGFL
Length:649
Mass (Da):71,111
Last modified:November 1, 1997 - v1
Checksum:iCC6901D168D01459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32134 Genomic DNA. Translation: BAA06860.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32134 Genomic DNA. Translation: BAA06860.1.

3D structure databases

ProteinModelPortaliQ11121.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of phospholipase B gene from the yeast Torulaspora delbrueckii."
    Watanabe Y., Yashiki Y., Sultana G.N., Maruyama M., Kangawa K., Tamai Y.
    FEMS Microbiol. Lett. 124:29-34(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: YL-32.

Entry informationi

Entry nameiPLB1_TORDE
AccessioniPrimary (citable) accession number: Q11121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.