Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q11119

- UBP14_SCHPO

UniProt

Q11119 - UBP14_SCHPO

Protein

Ubiquitin carboxyl-terminal hydrolase 14

Gene

ubp14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Aug 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei309 – 3091NucleophilePROSITE-ProRule annotation
    Active sitei730 – 7301Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri26 – 9166UBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri172 – 24574UBP-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. omega peptidase activity Source: InterPro
    2. ubiquitin-specific protease activity Source: PomBase
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase
    2. protein deubiquitination Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC19.A65.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 14 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 14
    UBA domain-containing protein 2
    Ubiquitin thioesterase 14
    Ubiquitin-specific-processing protease 14
    Gene namesi
    Name:ubp14
    Synonyms:ucp2
    ORF Names:SPBC6B1.06c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC6B1.06c.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 775775Ubiquitin carboxyl-terminal hydrolase 14PRO_0000080613Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei456 – 4561Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ11119.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4699892.
    STRINGi4896.SPBC6B1.06c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini300 – 774475USPAdd
    BLAST
    Domaini576 – 61742UBA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini639 – 67941UBA 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 2 UBA domains.PROSITE-ProRule annotation
    Contains 2 UBP-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri26 – 9166UBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri172 – 24574UBP-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5207.
    HOGENOMiHOG000162311.
    KOiK11836.
    OMAiGWKCSMC.
    OrthoDBiEOG74TX7J.
    PhylomeDBiQ11119.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR016652. Ubiquitinyl_hydrolase.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00627. UBA. 2 hits.
    PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 2 hits.
    [Graphical view]
    PIRSFiPIRSF016308. UBP. 1 hit.
    SMARTiSM00165. UBA. 2 hits.
    SM00290. ZnF_UBP. 2 hits.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    PROSITEiPS50030. UBA. 2 hits.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q11119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSCPHLTETN VVIPDNSQVI YREECVRCFN SQDEEGGIDL CLTCFQSGCG    50
    ETGLKHSLVH FEQTLHPIVV TIARQPKQKI NDEPPQKITK LEIREDSDED 100
    LYDYFYVPKC LVCNIILDIQ DPLLSLSLEA MKNATKASNK SQLTAWENEL 150
    TTCDHIINLP ENETYVTNLD NATCSKCDLA ENLWMCLTCG ALSCGRKQYG 200
    GGGGNGHALS HYDDTGHPLA VKLKSISPDG QADIYCYSCD EERIDPNIKT 250
    HMLNFGIDIA KLNKTEKSLA ELQLEQNLNW DFGASEEDDA SKRLFGPGLT 300
    GLKNLGNSCY LASTMQSLFS IKEFAIHELN LFNTYNSVCQ TPTTDLQCQL 350
    GKLADGLVSG KFSKPSKIGL LNNPSSSILP YQDGLRPFMF KDVVGQGHSE 400
    FGTSQQQDAY EFLLYLLGKI RKSSIAKTDI TKIFDFETEQ KLSCLSCKRV 450
    RYSSFSSQGL TLTVPRVKIG EIEGEQIYEE VSIDQCLDAT IQPDQMEYTC 500
    EACKSKLGAT TTTAMKSFPK VLILQANRFD LQGYQVKKLS IPIIVNEDGI 550
    YNFDRLMAKD HPNDEDYLPE KTETIEWNQS AIEQLQAMGF PLVRCQRALL 600
    ATGNSDTETA MNWLFEHMED PEIDKPIEVS ELLPKADSSV SEENVQSLCE 650
    FGFTVAQARK GLLESNNNIE RAVDWILNHP DESFEEPPLE GSDSSIKNEN 700
    MGSWESTNVP VNYNLKAIIS HKGSSAHAGH YVAFIRKEID GKQQWVLFND 750
    EKVLQVASLE EAKTTGYVYL FERLD 775
    Length:775
    Mass (Da):86,783
    Last modified:August 1, 1999 - v2
    Checksum:iEFF8942E925CF7C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA17049.1.
    D83659 Genomic DNA. Translation: BAA12032.1.
    PIRiT40647.
    RefSeqiNP_596085.1. NM_001021999.2.

    Genome annotation databases

    EnsemblFungiiSPBC6B1.06c.1; SPBC6B1.06c.1:pep; SPBC6B1.06c.
    GeneIDi2541157.
    KEGGispo:SPBC6B1.06c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA17049.1 .
    D83659 Genomic DNA. Translation: BAA12032.1 .
    PIRi T40647.
    RefSeqi NP_596085.1. NM_001021999.2.

    3D structure databases

    ProteinModelPortali Q11119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4699892.
    STRINGi 4896.SPBC6B1.06c-1.

    Protein family/group databases

    MEROPSi C19.A65.

    Proteomic databases

    MaxQBi Q11119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC6B1.06c.1 ; SPBC6B1.06c.1:pep ; SPBC6B1.06c .
    GeneIDi 2541157.
    KEGGi spo:SPBC6B1.06c.

    Organism-specific databases

    PomBasei SPBC6B1.06c.

    Phylogenomic databases

    eggNOGi COG5207.
    HOGENOMi HOG000162311.
    KOi K11836.
    OMAi GWKCSMC.
    OrthoDBi EOG74TX7J.
    PhylomeDBi Q11119.

    Miscellaneous databases

    NextBioi 20802270.
    PROi Q11119.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR016652. Ubiquitinyl_hydrolase.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00627. UBA. 2 hits.
    PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF016308. UBP. 1 hit.
    SMARTi SM00165. UBA. 2 hits.
    SM00290. ZnF_UBP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    PROSITEi PS50030. UBA. 2 hits.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Fission yeast TPR gene involved in G0 transition."
      Okazaki K., Okayama H.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-386.
    3. "Proteins containing the UBA domain are able to bind to multi-ubiquitin chains."
      Wilkinson C.R.M., Seeger M., Hartmann-Petersen R., Stone M., Wallace M., Semple C., Gordon C.
      Nat. Cell Biol. 3:939-943(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiUBP14_SCHPO
    AccessioniPrimary (citable) accession number: Q11119
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: August 1, 1999
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3