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Q11119 (UBP14_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 14

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 14
UBA domain-containing protein 2
Ubiquitin thioesterase 14
Ubiquitin-specific-processing protease 14
Gene names
Name:ubp14
Synonyms:ucp2
ORF Names:SPBC6B1.06c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length775 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 2 UBA domains.

Contains 2 UBP-type zinc fingers.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 775775Ubiquitin carboxyl-terminal hydrolase 14
PRO_0000080613

Regions

Domain300 – 774475USP
Domain576 – 61742UBA 1
Domain639 – 67941UBA 2
Zinc finger26 – 9166UBP-type 1
Zinc finger172 – 24574UBP-type 2

Sites

Active site3091Nucleophile By similarity
Active site7301Proton acceptor By similarity

Amino acid modifications

Modified residue4561Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q11119 [UniParc].

Last modified August 1, 1999. Version 2.
Checksum: EFF8942E925CF7C0

FASTA77586,783
        10         20         30         40         50         60 
MSCPHLTETN VVIPDNSQVI YREECVRCFN SQDEEGGIDL CLTCFQSGCG ETGLKHSLVH 

        70         80         90        100        110        120 
FEQTLHPIVV TIARQPKQKI NDEPPQKITK LEIREDSDED LYDYFYVPKC LVCNIILDIQ 

       130        140        150        160        170        180 
DPLLSLSLEA MKNATKASNK SQLTAWENEL TTCDHIINLP ENETYVTNLD NATCSKCDLA 

       190        200        210        220        230        240 
ENLWMCLTCG ALSCGRKQYG GGGGNGHALS HYDDTGHPLA VKLKSISPDG QADIYCYSCD 

       250        260        270        280        290        300 
EERIDPNIKT HMLNFGIDIA KLNKTEKSLA ELQLEQNLNW DFGASEEDDA SKRLFGPGLT 

       310        320        330        340        350        360 
GLKNLGNSCY LASTMQSLFS IKEFAIHELN LFNTYNSVCQ TPTTDLQCQL GKLADGLVSG 

       370        380        390        400        410        420 
KFSKPSKIGL LNNPSSSILP YQDGLRPFMF KDVVGQGHSE FGTSQQQDAY EFLLYLLGKI 

       430        440        450        460        470        480 
RKSSIAKTDI TKIFDFETEQ KLSCLSCKRV RYSSFSSQGL TLTVPRVKIG EIEGEQIYEE 

       490        500        510        520        530        540 
VSIDQCLDAT IQPDQMEYTC EACKSKLGAT TTTAMKSFPK VLILQANRFD LQGYQVKKLS 

       550        560        570        580        590        600 
IPIIVNEDGI YNFDRLMAKD HPNDEDYLPE KTETIEWNQS AIEQLQAMGF PLVRCQRALL 

       610        620        630        640        650        660 
ATGNSDTETA MNWLFEHMED PEIDKPIEVS ELLPKADSSV SEENVQSLCE FGFTVAQARK 

       670        680        690        700        710        720 
GLLESNNNIE RAVDWILNHP DESFEEPPLE GSDSSIKNEN MGSWESTNVP VNYNLKAIIS 

       730        740        750        760        770 
HKGSSAHAGH YVAFIRKEID GKQQWVLFND EKVLQVASLE EAKTTGYVYL FERLD 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Fission yeast TPR gene involved in G0 transition."
Okazaki K., Okayama H.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-386.
[3]"Proteins containing the UBA domain are able to bind to multi-ubiquitin chains."
Wilkinson C.R.M., Seeger M., Hartmann-Petersen R., Stone M., Wallace M., Semple C., Gordon C.
Nat. Cell Biol. 3:939-943(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAA17049.1.
D83659 Genomic DNA. Translation: BAA12032.1.
PIRT40647.
RefSeqNP_596085.1. NM_001021999.2.

3D structure databases

ProteinModelPortalQ11119.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4699892.
STRING4896.SPBC6B1.06c-1.

Protein family/group databases

MEROPSC19.A65.

Proteomic databases

MaxQBQ11119.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC6B1.06c.1; SPBC6B1.06c.1:pep; SPBC6B1.06c.
GeneID2541157.
KEGGspo:SPBC6B1.06c.

Organism-specific databases

PomBaseSPBC6B1.06c.

Phylogenomic databases

eggNOGCOG5207.
HOGENOMHOG000162311.
KOK11836.
OMAGWKCSMC.
OrthoDBEOG74TX7J.
PhylomeDBQ11119.

Family and domain databases

Gene3D3.30.40.10. 2 hits.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR016652. Ubiquitinyl_hydrolase.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00627. UBA. 2 hits.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 2 hits.
[Graphical view]
PIRSFPIRSF016308. UBP. 1 hit.
SMARTSM00165. UBA. 2 hits.
SM00290. ZnF_UBP. 2 hits.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
PROSITEPS50030. UBA. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802270.
PROQ11119.

Entry information

Entry nameUBP14_SCHPO
AccessionPrimary (citable) accession number: Q11119
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: August 1, 1999
Last modified: May 14, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Peptidase families

Classification of peptidase families and list of entries