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Q11119

- UBP14_SCHPO

UniProt

Q11119 - UBP14_SCHPO

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Protein
Ubiquitin carboxyl-terminal hydrolase 14
Gene
ubp14, ucp2, SPBC6B1.06c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei309 – 3091Nucleophile By similarity
Active sitei730 – 7301Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 9166UBP-type 1
Add
BLAST
Zinc fingeri172 – 24574UBP-type 2
Add
BLAST

GO - Molecular functioni

  1. omega peptidase activity Source: InterPro
  2. ubiquitin-specific protease activity Source: PomBase
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase
  2. protein deubiquitination Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.A65.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 14 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 14
UBA domain-containing protein 2
Ubiquitin thioesterase 14
Ubiquitin-specific-processing protease 14
Gene namesi
Name:ubp14
Synonyms:ucp2
ORF Names:SPBC6B1.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC6B1.06c.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775Ubiquitin carboxyl-terminal hydrolase 14
PRO_0000080613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei456 – 4561Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ11119.

Interactioni

Protein-protein interaction databases

MINTiMINT-4699892.
STRINGi4896.SPBC6B1.06c-1.

Structurei

3D structure databases

ProteinModelPortaliQ11119.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 774475USP
Add
BLAST
Domaini576 – 61742UBA 1
Add
BLAST
Domaini639 – 67941UBA 2
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 2 UBA domains.
Contains 1 USP domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5207.
HOGENOMiHOG000162311.
KOiK11836.
OMAiGWKCSMC.
OrthoDBiEOG74TX7J.
PhylomeDBiQ11119.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR016652. Ubiquitinyl_hydrolase.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00627. UBA. 2 hits.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 2 hits.
[Graphical view]
PIRSFiPIRSF016308. UBP. 1 hit.
SMARTiSM00165. UBA. 2 hits.
SM00290. ZnF_UBP. 2 hits.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS50030. UBA. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11119-1 [UniParc]FASTAAdd to Basket

« Hide

MSCPHLTETN VVIPDNSQVI YREECVRCFN SQDEEGGIDL CLTCFQSGCG    50
ETGLKHSLVH FEQTLHPIVV TIARQPKQKI NDEPPQKITK LEIREDSDED 100
LYDYFYVPKC LVCNIILDIQ DPLLSLSLEA MKNATKASNK SQLTAWENEL 150
TTCDHIINLP ENETYVTNLD NATCSKCDLA ENLWMCLTCG ALSCGRKQYG 200
GGGGNGHALS HYDDTGHPLA VKLKSISPDG QADIYCYSCD EERIDPNIKT 250
HMLNFGIDIA KLNKTEKSLA ELQLEQNLNW DFGASEEDDA SKRLFGPGLT 300
GLKNLGNSCY LASTMQSLFS IKEFAIHELN LFNTYNSVCQ TPTTDLQCQL 350
GKLADGLVSG KFSKPSKIGL LNNPSSSILP YQDGLRPFMF KDVVGQGHSE 400
FGTSQQQDAY EFLLYLLGKI RKSSIAKTDI TKIFDFETEQ KLSCLSCKRV 450
RYSSFSSQGL TLTVPRVKIG EIEGEQIYEE VSIDQCLDAT IQPDQMEYTC 500
EACKSKLGAT TTTAMKSFPK VLILQANRFD LQGYQVKKLS IPIIVNEDGI 550
YNFDRLMAKD HPNDEDYLPE KTETIEWNQS AIEQLQAMGF PLVRCQRALL 600
ATGNSDTETA MNWLFEHMED PEIDKPIEVS ELLPKADSSV SEENVQSLCE 650
FGFTVAQARK GLLESNNNIE RAVDWILNHP DESFEEPPLE GSDSSIKNEN 700
MGSWESTNVP VNYNLKAIIS HKGSSAHAGH YVAFIRKEID GKQQWVLFND 750
EKVLQVASLE EAKTTGYVYL FERLD 775
Length:775
Mass (Da):86,783
Last modified:August 1, 1999 - v2
Checksum:iEFF8942E925CF7C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17049.1.
D83659 Genomic DNA. Translation: BAA12032.1.
PIRiT40647.
RefSeqiNP_596085.1. NM_001021999.2.

Genome annotation databases

EnsemblFungiiSPBC6B1.06c.1; SPBC6B1.06c.1:pep; SPBC6B1.06c.
GeneIDi2541157.
KEGGispo:SPBC6B1.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17049.1 .
D83659 Genomic DNA. Translation: BAA12032.1 .
PIRi T40647.
RefSeqi NP_596085.1. NM_001021999.2.

3D structure databases

ProteinModelPortali Q11119.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4699892.
STRINGi 4896.SPBC6B1.06c-1.

Protein family/group databases

MEROPSi C19.A65.

Proteomic databases

MaxQBi Q11119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC6B1.06c.1 ; SPBC6B1.06c.1:pep ; SPBC6B1.06c .
GeneIDi 2541157.
KEGGi spo:SPBC6B1.06c.

Organism-specific databases

PomBasei SPBC6B1.06c.

Phylogenomic databases

eggNOGi COG5207.
HOGENOMi HOG000162311.
KOi K11836.
OMAi GWKCSMC.
OrthoDBi EOG74TX7J.
PhylomeDBi Q11119.

Miscellaneous databases

NextBioi 20802270.
PROi Q11119.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR016652. Ubiquitinyl_hydrolase.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00627. UBA. 2 hits.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 2 hits.
[Graphical view ]
PIRSFi PIRSF016308. UBP. 1 hit.
SMARTi SM00165. UBA. 2 hits.
SM00290. ZnF_UBP. 2 hits.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
PROSITEi PS50030. UBA. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Fission yeast TPR gene involved in G0 transition."
    Okazaki K., Okayama H.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-386.
  3. "Proteins containing the UBA domain are able to bind to multi-ubiquitin chains."
    Wilkinson C.R.M., Seeger M., Hartmann-Petersen R., Stone M., Wallace M., Semple C., Gordon C.
    Nat. Cell Biol. 3:939-943(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiUBP14_SCHPO
AccessioniPrimary (citable) accession number: Q11119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: August 1, 1999
Last modified: May 14, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi