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Q11119

- UBP14_SCHPO

UniProt

Q11119 - UBP14_SCHPO

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Protein

Ubiquitin carboxyl-terminal hydrolase 14

Gene

ubp14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei309 – 3091NucleophilePROSITE-ProRule annotation
Active sitei730 – 7301Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 9166UBP-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 24574UBP-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. omega peptidase activity Source: InterPro
  2. ubiquitin-specific protease activity Source: PomBase
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase
  2. protein deubiquitination Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.A65.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 14 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 14
UBA domain-containing protein 2
Ubiquitin thioesterase 14
Ubiquitin-specific-processing protease 14
Gene namesi
Name:ubp14
Synonyms:ucp2
ORF Names:SPBC6B1.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC6B1.06c.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775Ubiquitin carboxyl-terminal hydrolase 14PRO_0000080613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei456 – 4561Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ11119.

Interactioni

Protein-protein interaction databases

BioGridi277672. 1 interaction.
MINTiMINT-4699892.
STRINGi4896.SPBC6B1.06c-1.

Structurei

3D structure databases

ProteinModelPortaliQ11119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 774475USPAdd
BLAST
Domaini576 – 61742UBA 1PROSITE-ProRule annotationAdd
BLAST
Domaini639 – 67941UBA 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 2 UBA domains.PROSITE-ProRule annotation
Contains 2 UBP-type zinc fingers.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 9166UBP-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 24574UBP-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5207.
HOGENOMiHOG000162311.
InParanoidiQ11119.
KOiK11836.
OMAiGWKCSMC.
OrthoDBiEOG74TX7J.
PhylomeDBiQ11119.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR016652. Ubiquitinyl_hydrolase.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00627. UBA. 2 hits.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 2 hits.
[Graphical view]
PIRSFiPIRSF016308. UBP. 1 hit.
SMARTiSM00165. UBA. 2 hits.
SM00290. ZnF_UBP. 2 hits.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS50030. UBA. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11119-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCPHLTETN VVIPDNSQVI YREECVRCFN SQDEEGGIDL CLTCFQSGCG
60 70 80 90 100
ETGLKHSLVH FEQTLHPIVV TIARQPKQKI NDEPPQKITK LEIREDSDED
110 120 130 140 150
LYDYFYVPKC LVCNIILDIQ DPLLSLSLEA MKNATKASNK SQLTAWENEL
160 170 180 190 200
TTCDHIINLP ENETYVTNLD NATCSKCDLA ENLWMCLTCG ALSCGRKQYG
210 220 230 240 250
GGGGNGHALS HYDDTGHPLA VKLKSISPDG QADIYCYSCD EERIDPNIKT
260 270 280 290 300
HMLNFGIDIA KLNKTEKSLA ELQLEQNLNW DFGASEEDDA SKRLFGPGLT
310 320 330 340 350
GLKNLGNSCY LASTMQSLFS IKEFAIHELN LFNTYNSVCQ TPTTDLQCQL
360 370 380 390 400
GKLADGLVSG KFSKPSKIGL LNNPSSSILP YQDGLRPFMF KDVVGQGHSE
410 420 430 440 450
FGTSQQQDAY EFLLYLLGKI RKSSIAKTDI TKIFDFETEQ KLSCLSCKRV
460 470 480 490 500
RYSSFSSQGL TLTVPRVKIG EIEGEQIYEE VSIDQCLDAT IQPDQMEYTC
510 520 530 540 550
EACKSKLGAT TTTAMKSFPK VLILQANRFD LQGYQVKKLS IPIIVNEDGI
560 570 580 590 600
YNFDRLMAKD HPNDEDYLPE KTETIEWNQS AIEQLQAMGF PLVRCQRALL
610 620 630 640 650
ATGNSDTETA MNWLFEHMED PEIDKPIEVS ELLPKADSSV SEENVQSLCE
660 670 680 690 700
FGFTVAQARK GLLESNNNIE RAVDWILNHP DESFEEPPLE GSDSSIKNEN
710 720 730 740 750
MGSWESTNVP VNYNLKAIIS HKGSSAHAGH YVAFIRKEID GKQQWVLFND
760 770
EKVLQVASLE EAKTTGYVYL FERLD
Length:775
Mass (Da):86,783
Last modified:August 1, 1999 - v2
Checksum:iEFF8942E925CF7C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17049.1.
D83659 Genomic DNA. Translation: BAA12032.1.
PIRiT40647.
RefSeqiNP_596085.1. NM_001021999.2.

Genome annotation databases

EnsemblFungiiSPBC6B1.06c.1; SPBC6B1.06c.1:pep; SPBC6B1.06c.
GeneIDi2541157.
KEGGispo:SPBC6B1.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17049.1 .
D83659 Genomic DNA. Translation: BAA12032.1 .
PIRi T40647.
RefSeqi NP_596085.1. NM_001021999.2.

3D structure databases

ProteinModelPortali Q11119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277672. 1 interaction.
MINTi MINT-4699892.
STRINGi 4896.SPBC6B1.06c-1.

Protein family/group databases

MEROPSi C19.A65.

Proteomic databases

MaxQBi Q11119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC6B1.06c.1 ; SPBC6B1.06c.1:pep ; SPBC6B1.06c .
GeneIDi 2541157.
KEGGi spo:SPBC6B1.06c.

Organism-specific databases

PomBasei SPBC6B1.06c.

Phylogenomic databases

eggNOGi COG5207.
HOGENOMi HOG000162311.
InParanoidi Q11119.
KOi K11836.
OMAi GWKCSMC.
OrthoDBi EOG74TX7J.
PhylomeDBi Q11119.

Miscellaneous databases

NextBioi 20802270.
PROi Q11119.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR016652. Ubiquitinyl_hydrolase.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00627. UBA. 2 hits.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 2 hits.
[Graphical view ]
PIRSFi PIRSF016308. UBP. 1 hit.
SMARTi SM00165. UBA. 2 hits.
SM00290. ZnF_UBP. 2 hits.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
PROSITEi PS50030. UBA. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Fission yeast TPR gene involved in G0 transition."
    Okazaki K., Okayama H.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-386.
  3. "Proteins containing the UBA domain are able to bind to multi-ubiquitin chains."
    Wilkinson C.R.M., Seeger M., Hartmann-Petersen R., Stone M., Wallace M., Semple C., Gordon C.
    Nat. Cell Biol. 3:939-943(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiUBP14_SCHPO
AccessioniPrimary (citable) accession number: Q11119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: August 1, 1999
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3