Q11112 (YX05_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein kinase C03B1.5
EC=2.7.10.2

Gene names

ORF Names:

C03B1.5

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Putative tyrosine-protein kinase C03B1.5		PRO_0000088187
Regions
	Domain	25 – 288	264	Protein kinase
	Nucleotide binding	31 – 39	9	ATP By similarity
Sites
	Active site	155	1	Proton acceptor By similarity
	Binding site	62	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11112 [UniParc]. Last modified May 10, 2005. Version 3. Checksum: B709F2DA658F309F	FASTA	328	37,213
	10 20 30 40 50 60 MQSAQKSKTN GDTSLFLMKD IPQYWSPALK IGSGAFGEVM LVHSDRLDAR GEQILHNEFA 70 80 90 100 110 120 LKVIRFPECD YHKIIREVNT HTLCRHHDNV LFIGSIYCQT FQQGLRVQMC LEYAALSDLS 130 140 150 160 170 180 LLASSETFES HVAYICKNLI SALIHIHNLG IVHGDLSVKN ILMTHEGVVK LSDFGMANTF 190 200 210 220 230 240 EQTRKSKNQS ILGTPGFIAP EIINLQGYDG KADLWGLGIL SLFLLKGENP FKKCTQFDLE 250 260 270 280 290 300 SYKVSISESF YPDYSNYSTP LQEFMSSLKD YNPEFRSSAL HASSQTYLKT SCSQSEILNY 310 320 YKRLRRTRGM DLPWPEEIHT FSVPVSLE

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080304 Genomic DNA. Translation: CCD62741.1.
PIR	T15383.
RefSeq	NP_509065.2. NM_076664.4.
3D structure databases
ProteinModelPortal	Q11112.
SMR	Q11112. Positions 20-308.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C03B1.5; C03B1.5; C03B1.5.
GeneID	182148.
KEGG	cel:CELE_C03B1.5.
UCSC	C03B1.5. c. elegans.
Organism-specific databases
CTD	182148.
WormBase	C03B1.5; CE37605; WBGene00015376.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00680000099789.
HOGENOM	HOG000076925.
InParanoid	Q11112.
OMA	MCLEYAA.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	916560.

Entry information

Entry name

YX05_CAEEL

Accession

Primary (citable) accession number: Q11112

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 91 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project