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Q11112

- YX05_CAEEL

UniProt

Q11112 - YX05_CAEEL

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Protein
Putative tyrosine-protein kinase C03B1.5
Gene
C03B1.5
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621ATP By similarity
Active sitei155 – 1551Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: RefGenome
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. MAPK cascade Source: GOC
  2. activation of MAPKK activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ11112.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein kinase C03B1.5 (EC:2.7.10.2)
Gene namesi
ORF Names:C03B1.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC03B1.5; CE37605; WBGene00015376.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Putative tyrosine-protein kinase C03B1.5
PRO_0000088187Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.C03B1.5.

Structurei

3D structure databases

ProteinModelPortaliQ11112.
SMRiQ11112. Positions 20-308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 288264Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00670000097939.
HOGENOMiHOG000076925.
InParanoidiQ11112.
OMAiMCLEYAA.
OrthoDBiEOG7GN2S0.
PhylomeDBiQ11112.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11112-1 [UniParc]FASTAAdd to Basket

« Hide

MQSAQKSKTN GDTSLFLMKD IPQYWSPALK IGSGAFGEVM LVHSDRLDAR    50
GEQILHNEFA LKVIRFPECD YHKIIREVNT HTLCRHHDNV LFIGSIYCQT 100
FQQGLRVQMC LEYAALSDLS LLASSETFES HVAYICKNLI SALIHIHNLG 150
IVHGDLSVKN ILMTHEGVVK LSDFGMANTF EQTRKSKNQS ILGTPGFIAP 200
EIINLQGYDG KADLWGLGIL SLFLLKGENP FKKCTQFDLE SYKVSISESF 250
YPDYSNYSTP LQEFMSSLKD YNPEFRSSAL HASSQTYLKT SCSQSEILNY 300
YKRLRRTRGM DLPWPEEIHT FSVPVSLE 328
Length:328
Mass (Da):37,213
Last modified:May 10, 2005 - v3
Checksum:iB709F2DA658F309F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080304 Genomic DNA. Translation: CCD62741.1.
PIRiT15383.
RefSeqiNP_509065.2. NM_076664.4.
UniGeneiCel.11493.

Genome annotation databases

EnsemblMetazoaiC03B1.5; C03B1.5; WBGene00015376.
GeneIDi182148.
KEGGicel:CELE_C03B1.5.
UCSCiC03B1.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080304 Genomic DNA. Translation: CCD62741.1 .
PIRi T15383.
RefSeqi NP_509065.2. NM_076664.4.
UniGenei Cel.11493.

3D structure databases

ProteinModelPortali Q11112.
SMRi Q11112. Positions 20-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.C03B1.5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C03B1.5 ; C03B1.5 ; WBGene00015376 .
GeneIDi 182148.
KEGGi cel:CELE_C03B1.5.
UCSCi C03B1.5. c. elegans.

Organism-specific databases

CTDi 182148.
WormBasei C03B1.5 ; CE37605 ; WBGene00015376 .

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00670000097939.
HOGENOMi HOG000076925.
InParanoidi Q11112.
OMAi MCLEYAA.
OrthoDBi EOG7GN2S0.
PhylomeDBi Q11112.

Enzyme and pathway databases

SignaLinki Q11112.

Miscellaneous databases

NextBioi 916560.
PROi Q11112.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYX05_CAEEL
AccessioniPrimary (citable) accession number: Q11112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 10, 2005
Last modified: June 11, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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