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Q110U9

- PANCY_TRIEI

UniProt

Q110U9 - PANCY_TRIEI

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Protein
Bifunctional pantoate ligase/cytidylate kinase
Gene
panC/cmk, Tery_2799
Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation
Displays a CMP kinase activity By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton donor By similarity
Binding sitei65 – 651Beta-alanine By similarity
Binding sitei65 – 651Pantoate By similarity
Binding sitei166 – 1661Pantoate By similarity
Binding sitei189 – 1891ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418ATP By similarity
Nucleotide bindingi160 – 1634ATP By similarity
Nucleotide bindingi197 – 2004ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTERY203124:GJDR-2825-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:Tery_2799
OrganismiTrichodesmium erythraeum (strain IMS101)
Taxonomic identifieri203124 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium
ProteomesiUP000008878: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
PRO_0000333303Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203124.Tery_2799.

Structurei

3D structure databases

ProteinModelPortaliQ110U9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 293293Pantoate--beta-alanine ligaseUniRule annotation
Add
BLAST
Regioni294 – 528235Cytidylate kinaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q110U9-1 [UniParc]FASTAAdd to Basket

« Hide

MRLFTTIAGL NCYLNLLRNE QKKSPDTIGL VPTMGALHKG HLSLIKRARE    50
ENTITVVSIF INPLQFAPRE DFKEYPRQLE IDKEFCEKEG VDVIFAPTPE 100
TMGMKNALST DAQDSTTTVV SPSHMTSIMC GVSRPNFFQG VATIVTKLLN 150
IVKPNNAYFG QKDAQQLAII KQLVKDLSLP VNIVYCPIIR EASGLAISSR 200
NQYLTPEQKE QASMLYASLC YGRKIFLENQ DTPNILETVE NAVKEKLASQ 250
PVLKLEYLEI VDPETLKPLE NIQNIGLLAI AAYIGSCRLI DNILLRNRKP 300
IIAIDGPAGA GKSTVTKLVG QSLGLLYLDT GAMYRAVTWM VLQSGVPVTD 350
QAQVAELVSQ CQISFNSPEN NHVVINGQDV TVAIRSREVT NNVSIVAAQP 400
TVRYFMVKQQ QQFGAKGGIV AEGRDIGSHV FPNAELKIFL TASLKERSRR 450
RLVELKQKGQ TNISLEEVEK EIICRDQKDT NRKISPLRKS SDAVEISTDG 500
LSIGEVTQKI VDIFKTTCYG KSSVNNII 528
Length:528
Mass (Da):58,427
Last modified:August 22, 2006 - v1
Checksum:iEC536758F6078812
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000393 Genomic DNA. Translation: ABG51975.1.
RefSeqiWP_011612336.1. NC_008312.1.
YP_722448.1. NC_008312.1.

Genome annotation databases

EnsemblBacteriaiABG51975; ABG51975; Tery_2799.
GeneIDi4245333.
KEGGiter:Tery_2799.
PATRICi23990266. VBITriEry99848_3558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000393 Genomic DNA. Translation: ABG51975.1 .
RefSeqi WP_011612336.1. NC_008312.1.
YP_722448.1. NC_008312.1.

3D structure databases

ProteinModelPortali Q110U9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 203124.Tery_2799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG51975 ; ABG51975 ; Tery_2799 .
GeneIDi 4245333.
KEGGi ter:Tery_2799.
PATRICi 23990266. VBITriEry99848_3558.

Phylogenomic databases

eggNOGi COG0283.
HOGENOMi HOG000233355.
KOi K13799.
OMAi LGEKDWQ.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci TERY203124:GJDR-2825-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProi IPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IMS101.

Entry informationi

Entry nameiPANCY_TRIEI
AccessioniPrimary (citable) accession number: Q110U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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