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Q110U9

- PANCY_TRIEI

UniProt

Q110U9 - PANCY_TRIEI

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
    Displays a CMP kinase activity.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
    ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411Proton donorUniRule annotation
    Binding sitei65 – 651Beta-alanineUniRule annotation
    Binding sitei65 – 651PantoateUniRule annotation
    Binding sitei166 – 1661PantoateUniRule annotation
    Binding sitei189 – 1891ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 418ATPUniRule annotation
    Nucleotide bindingi160 – 1634ATPUniRule annotation
    Nucleotide bindingi197 – 2004ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTERY203124:GJDR-2825-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
    Including the following 2 domains:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Cytidylate kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
    Short name:
    CKUniRule annotation
    Alternative name(s):
    Cytidine monophosphate kinaseUniRule annotation
    Short name:
    CMP kinaseUniRule annotation
    Gene namesi
    Name:panC/cmkUniRule annotation
    Ordered Locus Names:Tery_2799
    OrganismiTrichodesmium erythraeum (strain IMS101)
    Taxonomic identifieri203124 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium
    ProteomesiUP000008878: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528Bifunctional pantoate ligase/cytidylate kinasePRO_0000333303Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203124.Tery_2799.

    Structurei

    3D structure databases

    ProteinModelPortaliQ110U9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 293293Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni294 – 528235Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q110U9-1 [UniParc]FASTAAdd to Basket

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    MRLFTTIAGL NCYLNLLRNE QKKSPDTIGL VPTMGALHKG HLSLIKRARE    50
    ENTITVVSIF INPLQFAPRE DFKEYPRQLE IDKEFCEKEG VDVIFAPTPE 100
    TMGMKNALST DAQDSTTTVV SPSHMTSIMC GVSRPNFFQG VATIVTKLLN 150
    IVKPNNAYFG QKDAQQLAII KQLVKDLSLP VNIVYCPIIR EASGLAISSR 200
    NQYLTPEQKE QASMLYASLC YGRKIFLENQ DTPNILETVE NAVKEKLASQ 250
    PVLKLEYLEI VDPETLKPLE NIQNIGLLAI AAYIGSCRLI DNILLRNRKP 300
    IIAIDGPAGA GKSTVTKLVG QSLGLLYLDT GAMYRAVTWM VLQSGVPVTD 350
    QAQVAELVSQ CQISFNSPEN NHVVINGQDV TVAIRSREVT NNVSIVAAQP 400
    TVRYFMVKQQ QQFGAKGGIV AEGRDIGSHV FPNAELKIFL TASLKERSRR 450
    RLVELKQKGQ TNISLEEVEK EIICRDQKDT NRKISPLRKS SDAVEISTDG 500
    LSIGEVTQKI VDIFKTTCYG KSSVNNII 528
    Length:528
    Mass (Da):58,427
    Last modified:August 22, 2006 - v1
    Checksum:iEC536758F6078812
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000393 Genomic DNA. Translation: ABG51975.1.
    RefSeqiWP_011612336.1. NC_008312.1.
    YP_722448.1. NC_008312.1.

    Genome annotation databases

    EnsemblBacteriaiABG51975; ABG51975; Tery_2799.
    GeneIDi4245333.
    KEGGiter:Tery_2799.
    PATRICi23990266. VBITriEry99848_3558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000393 Genomic DNA. Translation: ABG51975.1 .
    RefSeqi WP_011612336.1. NC_008312.1.
    YP_722448.1. NC_008312.1.

    3D structure databases

    ProteinModelPortali Q110U9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203124.Tery_2799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG51975 ; ABG51975 ; Tery_2799 .
    GeneIDi 4245333.
    KEGGi ter:Tery_2799.
    PATRICi 23990266. VBITriEry99848_3558.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci TERY203124:GJDR-2825-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IMS101.

    Entry informationi

    Entry nameiPANCY_TRIEI
    AccessioniPrimary (citable) accession number: Q110U9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3