Q11087 (PLC12_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-12
Short name=1-AGP acyltransferase
Short name=1-AGPAT
EC=2.3.1.51

Alternative name(s):
Lysophosphatidic acid acyltransferase
Short name=LPAAT

Gene names

Name:	acl-12
ORF Names:	C01C10.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid storage Inferred from mutant phenotype. Source: WormBase phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-12		PRO_0000065097
Regions
	Transmembrane	47 – 67	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Motif	124 – 129	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q11087 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: FB5C062A0172A8C1	FASTA	391	44,718
	10 20 30 40 50 60 MLKSGLMDTD DQKVGVRVAN IDMSERTDNV HLIEIRRIIS LVGAAYFFFM TAWVVPVACV 70 80 90 100 110 120 ITVSLLFPLM LFSTPLFNYL EHKLCAMVNA HWNAVSVFVG ATVTEYGTNL AGYAEEKCLL 130 140 150 160 170 180 LANHLGLLDH FVLMQSLNGK GSIRSRWMWV IYNIWKYTPL GVMWTSHGNF FVNGGVSKRD 190 200 210 220 230 240 SVLSSFRDHL KNSFYKYDYG WVIMYPEGSR LYLVKNSGRT FAEKNGLKPL DNCVYPRTGA 250 260 270 280 290 300 AHAVLDVLGP TDDSLSMSKC GKGEPIKYII DATIGYRKGA VPDICDVMMG DWESVEASQF 310 320 330 340 350 360 AVHYDVIPVK PEWSDENLLK EFLYERYIIK DKLLAEFYKT GHFPGDKTKV IPNNYEMMFA 370 380 390 QVFWGCLYYA HYVYWLRPLI VHSWTSFLSI F

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080255 Genomic DNA. Translation: CCD62384.1.
PIR	T15366.
RefSeq	NP_509260.1. NM_076859.3.
UniGene	Cel.7660.
3D structure databases
ProteinModelPortal	Q11087.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C01C10.3.1; C01C10.3.1; C01C10.3. C01C10.3.2; C01C10.3.2; C01C10.3.
GeneID	181001.
KEGG	cel:C01C10.3.
NMPDR	fig|6239.3.peg.23768.
UCSC	C01C10.3. c. elegans.
Organism-specific databases
CTD	181001.
WormBase	C01C10.3; CE02449; WBGene00015295; acl-12.
Phylogenomic databases
eggNOG	meNOG07015.
GeneTree	EMGT00050000014205.
HOGENOM	HBG388516.
InParanoid	Q11087.
OMA	WVIYNIW.
PhylomeDB	Q11087.
Gene expression databases
ArrayExpress	Q11087.
Family and domain databases
InterPro	IPR002123. Acyltransferase. [Graphical view]
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	911926.

Entry information

Entry name

PLC12_CAEEL

Accession

Primary (citable) accession number: Q11087

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project