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Protein

40 kDa peptidyl-prolyl cis-trans isomerase

Gene

wis2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
40 kDa peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin-40
Short name:
CYP-40
Rotamase
Gene namesi
Name:wis2
Synonyms:cyp5
ORF Names:SPAC1B3.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.03c
PomBaseiSPAC1B3.03c wis2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641771 – 35640 kDa peptidyl-prolyl cis-trans isomeraseAdd BLAST356

Proteomic databases

MaxQBiQ11004
PaxDbiQ11004
PRIDEiQ11004

PTM databases

iPTMnetiQ11004

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

BioGridi278998, 55 interactors
STRINGi4896.SPAC1B3.03c.1

Structurei

3D structure databases

ProteinModelPortaliQ11004
SMRiQ11004
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 166PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161
Repeati204 – 237TPR 1Add BLAST34
Repeati259 – 292TPR 2Add BLAST34
Repeati297 – 330TPR 3Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili328 – 354Sequence analysisAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

HOGENOMiHOG000065980
InParanoidiQ11004
KOiK05864
OMAiAMCAIKL
OrthoDBiEOG092C5DG5
PhylomeDBiQ11004

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR11071 PTHR11071, 2 hits
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q11004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYAYFKIS IDGKIQPTIY FELFDNVVPK TVKNFASLCN GFEKDGRCLT
60 70 80 90 100
YKGSRFHRVI KNFMLQGGDF TRGNGTGGES IYGEKFEDEN FELKHDKPFL
110 120 130 140 150
LSMANAGPNT NGSQFFITTV PTPHLDGKHV VFGKVIQGKS TVRTIENLET
160 170 180 190 200
KNDDPVVPVV IEECGTCTKD QIEAPKPDVT GDSLEEFPDD YEGDKSETAI
210 220 230 240 250
FKIASDLKGI ANKQFAQQNL DTAVAKWQKA LRYLMEYPVP NDDSKESPDF
260 270 280 290 300
WKEYNALRYS IYANLALVAL KQNKPQEAIR NANIVIEASN STELEKQKAY
310 320 330 340 350
YRLGCAQGLL KNFEESEKAL AKAGNDPAIS KKLAEIRQKK KDYKKRQQKA

YAKMFQ
Length:356
Mass (Da):40,162
Last modified:November 1, 1996 - v1
Checksum:i8418E3255F48B8DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91981 Genomic DNA Translation: CAA63034.1
CU329670 Genomic DNA Translation: CAB11232.1
PIRiS62327
RefSeqiNP_594787.1, NM_001020215.2

Genome annotation databases

EnsemblFungiiSPAC1B3.03c.1; SPAC1B3.03c.1:pep; SPAC1B3.03c
GeneIDi2542541
KEGGispo:SPAC1B3.03c

Similar proteinsi

Entry informationi

Entry nameiPPID_SCHPO
AccessioniPrimary (citable) accession number: Q11004
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health