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Protein

40 kDa peptidyl-prolyl cis-trans isomerase

Gene

wis2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptide binding Source: UniProtKB-KW
  • peptidyl-prolyl cis-trans isomerase activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Cyclosporin

Names & Taxonomyi

Protein namesi
Recommended name:
40 kDa peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin-40
Short name:
CYP-40
Rotamase
Gene namesi
Name:wis2
Synonyms:cyp5
ORF Names:SPAC1B3.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.03c.
PomBaseiSPAC1B3.03c. wis2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • protein complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 35635640 kDa peptidyl-prolyl cis-trans isomerasePRO_0000064177Add
BLAST

Proteomic databases

MaxQBiQ11004.

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

BioGridi278998. 54 interactions.
MINTiMINT-4699862.

Structurei

3D structure databases

ProteinModelPortaliQ11004.
SMRiQ11004. Positions 6-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 166161PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST
Repeati204 – 23734TPR 1Add
BLAST
Repeati259 – 29234TPR 2Add
BLAST
Repeati297 – 33034TPR 3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili328 – 35427Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 3 TPR repeats.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

HOGENOMiHOG000065980.
InParanoidiQ11004.
KOiK05864.
OMAiANSSACK.
OrthoDBiEOG757D7G.
PhylomeDBiQ11004.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYAYFKIS IDGKIQPTIY FELFDNVVPK TVKNFASLCN GFEKDGRCLT
60 70 80 90 100
YKGSRFHRVI KNFMLQGGDF TRGNGTGGES IYGEKFEDEN FELKHDKPFL
110 120 130 140 150
LSMANAGPNT NGSQFFITTV PTPHLDGKHV VFGKVIQGKS TVRTIENLET
160 170 180 190 200
KNDDPVVPVV IEECGTCTKD QIEAPKPDVT GDSLEEFPDD YEGDKSETAI
210 220 230 240 250
FKIASDLKGI ANKQFAQQNL DTAVAKWQKA LRYLMEYPVP NDDSKESPDF
260 270 280 290 300
WKEYNALRYS IYANLALVAL KQNKPQEAIR NANIVIEASN STELEKQKAY
310 320 330 340 350
YRLGCAQGLL KNFEESEKAL AKAGNDPAIS KKLAEIRQKK KDYKKRQQKA

YAKMFQ
Length:356
Mass (Da):40,162
Last modified:November 1, 1996 - v1
Checksum:i8418E3255F48B8DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91981 Genomic DNA. Translation: CAA63034.1.
CU329670 Genomic DNA. Translation: CAB11232.1.
PIRiS62327.
RefSeqiNP_594787.1. NM_001020215.2.

Genome annotation databases

EnsemblFungiiSPAC1B3.03c.1; SPAC1B3.03c.1:pep; SPAC1B3.03c.
GeneIDi2542541.
KEGGispo:SPAC1B3.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91981 Genomic DNA. Translation: CAA63034.1.
CU329670 Genomic DNA. Translation: CAB11232.1.
PIRiS62327.
RefSeqiNP_594787.1. NM_001020215.2.

3D structure databases

ProteinModelPortaliQ11004.
SMRiQ11004. Positions 6-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278998. 54 interactions.
MINTiMINT-4699862.

Proteomic databases

MaxQBiQ11004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1B3.03c.1; SPAC1B3.03c.1:pep; SPAC1B3.03c.
GeneIDi2542541.
KEGGispo:SPAC1B3.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.03c.
PomBaseiSPAC1B3.03c. wis2.

Phylogenomic databases

HOGENOMiHOG000065980.
InParanoidiQ11004.
KOiK05864.
OMAiANSSACK.
OrthoDBiEOG757D7G.
PhylomeDBiQ11004.

Miscellaneous databases

PROiQ11004.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A multicopy suppressor of a cell cycle defect in S. pombe encodes a heat shock-inducible 40 kDa cyclophilin-like protein."
    Weisman R., Creanor J., Fantes P.A.
    EMBO J. 15:447-456(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPPID_SCHPO
AccessioniPrimary (citable) accession number: Q11004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.