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Q10X06 (DDL_TRIEI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Tery_4217
OrganismTrichodesmium erythraeum (strain IMS101) [Complete proteome] [HAMAP]
Taxonomic identifier203124 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesTrichodesmium

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000030518

Regions

Domain149 – 358210ATP-grasp
Nucleotide binding185 – 24056ATP By similarity

Sites

Metal binding3111Magnesium or manganese 1 By similarity
Metal binding3251Magnesium or manganese 1 By similarity
Metal binding3251Magnesium or manganese 2 By similarity
Metal binding3271Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q10X06 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 3FF8DEF47165703D

FASTA36640,267
        10         20         30         40         50         60 
MTKLRVGLLF GGCSGEHEVS IRSAKVIATA LTKVQNKEKY ELIPIYIQKN GLWQPSDFSQ 

        70         80         90        100        110        120 
KVLNSDHPSL LQLTNENNHD LNTSLTQQSS SPLWQIPPQA AQVDVWFPIL HGPNGEDGTI 

       130        140        150        160        170        180 
QGLLKLMQVP FVGSGVLGSA MGMDKIAMKI AFDHAGLPQV KYQVVTRSQI WSNSCVFPKL 

       190        200        210        220        230        240 
CDDIETTLEY PCFVKPANLG SSVGIAKVRS RSELETALDN AASYDRRIIV EAGVEAKELE 

       250        260        270        280        290        300 
CAVLGNDMPK ASIVGEITYN SDFYDYETKY TEGKADLHIP ARVSEAIATK IKEMATQAFL 

       310        320        330        340        350        360 
AVDAAGLARV DFFYVEKTGE ILINEINTMP GFTSSSMYPM LWEASGIPFS ELVDTLIQLA 


LERHSK 

« Hide

References

[1]"Complete sequence of Trichodesmium erythraeum IMS101."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IMS101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000393 Genomic DNA. Translation: ABG53218.1.
RefSeqYP_723691.1. NC_008312.1.

3D structure databases

ProteinModelPortalQ10X06.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203124.Tery_4217.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG53218; ABG53218; Tery_4217.
GeneID4245869.
KEGGter:Tery_4217.
PATRIC23993887. VBITriEry99848_5347.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycTERY203124:GJDR-4262-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_TRIEI
AccessionPrimary (citable) accession number: Q10X06
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways