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Q10WR6 (HEMH_TRIEI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Tery_4313
OrganismTrichodesmium erythraeum (strain IMS101) [Complete proteome] [HAMAP]
Taxonomic identifier203124 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriales › Trichodesmium

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Ferrochelatase HAMAP MF_00323
PRO_1000019382

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q10WR6 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: E6BA861D69E4072B

FASTA38744,320
        10         20         30         40         50         60 
MSRVGILLLN LGGPEQLEDV RPFLFNLFSD PEIIRLPFPW LQKPLAWFIS TMRFQKSQEN 

        70         80         90        100        110        120 
YKEIGGGSPL RSITEEQALA IQQQLEQKGL LTQMYIGMRY WHPFTEEALT RIKREQVEKL 

       130        140        150        160        170        180 
VILPLYPQYS ISTSGSSFRL LDKLWEKDSE LKKIEYTVIP SWHQRPGYVQ AMVELITQQL 

       190        200        210        220        230        240 
DQSPNPDQVH IFFSAHGVPV SYVEEAGDPY QAEIEECVDK IMKTLNCSNP HTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLKPYTE DAIEELAAGG VKDLLVVPIS FVSEHIETLQ EIDIEYRELA EEAGISNFYR 

       310        320        330        340        350        360 
VPALNTHPVF INDLADLVME ALDAPSRDFS DAIQMKKIIK MYPQERWQWG LTTTAEVWNG 

       370        380 
RLAMVGFMAL LLELITGYGP LHFAGLL

« Hide

References

[1]"Complete sequence of Trichodesmium erythraeum IMS101."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IMS101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000393 Genomic DNA. Translation: ABG53308.1.
RefSeqYP_723781.1. NC_008312.1.

3D structure databases

ProteinModelPortalQ10WR6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ10WR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4245965.
GenomeReviewsGene locus Tery_4313 in contig CP000393_GR.
KEGGter:Tery_4313.
NMPDRfig|203124.1.peg.3124.
PATRIC23994135. VBITriEry99848_5471.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBQ10WR6.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycTERY203124:TERY_4313-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR023329. Chlorophyll_a/b-bd_dom.
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
Gene3DG3DSA:1.10.3460.10. G3DSA:1.10.3460.10. 1 hit.
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
SUPFAMSSF103511. SSF103511. 1 hit.
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_TRIEI
AccessionPrimary (citable) accession number: Q10WR6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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