Q10WL4 (PYRB_TRIEI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Tery_4368

Organism

Trichodesmium erythraeum (strain IMS101) [Complete proteome] [HAMAP]

Taxonomic identifier

203124 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Oscillatoriales › Trichodesmium

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321178

Sequences

	Sequence		Length	Mass (Da)
	Q10WL4 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: FBC321F4BDD3F58D	FASTA	331	36,670
	10 20 30 40 50 60 MSTNIWTPRH ILSLAEFTPT EYNIILQTAT SFQEVLGRRM KKVPALQGQV VANLFFEPST 70 80 90 100 110 120 RTRNSFELAA KRLSADTLNF APGTSSLTKG ETILDTAMTY LAMGTDMMVI RHRNAGVPAA 130 140 150 160 170 180 IASAMDRNGH QVRVLNAGDG QHEHPSQALL DLFTICKLLN STEPRIELLE TKKIAIVGDI 190 200 210 220 230 240 LHSRVARSNI WSLTASGAEV HLAGTPTLLP KYFGEFGKLR PSKLFVHWDI EPALEKADFV 250 260 270 280 290 300 MTLRLQKERM SQHLLPSLRE YHQLFGITRD RLKLCQPGVK ILHPGPVNRG VEISSDLMDD 310 320 330 PQLSLISQQV TSGIAVRMAL LYLLGGGKAD Q

References

[1]

"Complete sequence of Trichodesmium erythraeum IMS101." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IMS101.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000393 Genomic DNA. Translation: ABG53360.1.
RefSeq	YP_723833.1. NC_008312.1.
3D structure databases
ProteinModelPortal	Q10WL4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q10WL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4246021.
GenomeReviews	Gene locus Tery_4368 in contig CP000393_GR.
KEGG	ter:Tery_4368.
NMPDR	fig|203124.1.peg.3052.
PATRIC	23994273. VBITriEry99848_5539.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	VGIPIIN.
PhylomeDB	Q10WL4.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	TERY203124:TERY_4368-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_TRIEI

Accession

Primary (citable) accession number: Q10WL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program