Q10VY5 (Q10VY5_TRIEI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 2 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I 2 HAMAP MF_00223

Gene names

Name:	folE2 HAMAP MF_00223
Ordered Locus Names:	Tery_4616

Organism

Trichodesmium erythraeum (strain IMS101) [Complete proteome] [HAMAP] EMBL ABG53589.1

Taxonomic identifier

203124 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Oscillatoriales › Trichodesmium

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 Nucleotide-binding Zinc HAMAP MF_00223
Molecular function	Hydrolase HAMAP MF_00223 EMBL ABG53589.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	98	1	Zinc By similarity HAMAP MF_00223
	Metal binding	101	1	Zinc By similarity HAMAP MF_00223
	Metal binding	169	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	Q10VY5 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 261D919292A36E4A	FASTA	212	23,579
	10 20 30 40 50 60 MNLPTVPDFV SPNDLKTKYQ TSVTEAEMVQ AVRTLLIGLG ENPDREGLLD TPKRVVKALK 70 80 90 100 110 120 FLTSGYNQSL DELLNGAVFS EDTSEMVLVR DIDLFSSCEH HILPIIGRAH VAYIPNGKVI 130 140 150 160 170 180 GLSKIARICE MYARRLQVQE RLTAQIADAL QGLLRPLGVA VVVEATHMCM VMRGVQKTGS 190 200 210 WTTTSAMRGV FADDVKTRQE FMSLIKHSHN FH

References

[1]

"Complete sequence of Trichodesmium erythraeum IMS101." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IMS101.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000393 Genomic DNA. Translation: ABG53589.1.
RefSeq	YP_724062.1. NC_008312.1.
3D structure databases
ProteinModelPortal	Q10VY5.
SMR	Q10VY5. Positions 22-207.
ModBase	Search...
Protein-protein interaction databases
STRING	Q10VY5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4246270.
GenomeReviews	Gene locus Tery_4616 in contig CP000393_GR.
KEGG	ter:Tery_4616.
NMPDR	fig|203124.1.peg.4332.
PATRIC	23994911. VBITriEry99848_5857.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HBG370191.
OMA	CEAKHLC.
PhylomeDB	Q10VY5.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	TERY203124:TERY_4616-MONOMER.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q10VY5_TRIEI

Accession

Primary (citable) accession number: Q10VY5

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)