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Protein

Uroporphyrinogen-III synthase, chloroplastic

Gene

UROS

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, a precursor of tetrapyrroles such as chlorophyll, heme and phycobilins.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase, chloroplastic (HEMB)
  2. Porphobilinogen deaminase, chloroplastic (HEMC)
  3. Uroporphyrinogen-III synthase, chloroplastic (UROS)
  4. Uroporphyrinogen decarboxylase 2, chloroplastic (Os03g0337600), Uroporphyrinogen decarboxylase 1, chloroplastic (Os01g0622300)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processChlorophyll biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase, chloroplastic (EC:4.2.1.75)
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:UROS
Synonyms:HEMD
Ordered Locus Names:Os03g0186100, LOC_Os03g08730
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 50ChloroplastSequence analysisAdd BLAST50
ChainiPRO_000037606851 – 302Uroporphyrinogen-III synthase, chloroplasticAdd BLAST252

Proteomic databases

PaxDbiQ10QR9.
PRIDEiQ10QR9.

Expressioni

Gene expression databases

GenevisibleiQ10QR9. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g08730.1.

Structurei

3D structure databases

SMRiQ10QR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IFS1. Eukaryota.
ENOG4111P6K. LUCA.
InParanoidiQ10QR9.
KOiK01719.
OMAiACIGETS.
OrthoDBiEOG09360IGG.

Family and domain databases

CDDicd06578. HemD. 1 hit.
InterProiView protein in InterPro
IPR036108. 4pyrrol_syn_uPrphyn_synt_sf.
IPR003754. 4pyrrol_synth_uPrphyn_synth.
PfamiView protein in Pfam
PF02602. HEM4. 1 hit.
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10QR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSSSSHLL PFSRPPATFP RARHAGGGRG RAGATGRFIA CSSPPPPDVV
60 70 80 90 100
VTRERGKNAK LIAALEKHNV QSLELPLIKH VEGPDTDRLS AVLRDEKFDW
110 120 130 140 150
ITITSPEAAA VFLEGWKAAG NPKVRIAVVG AGTERVFDEV IQYNDGSLEV
160 170 180 190 200
AFSPSKAMGK FLASELPRTT ETTCKVLYPA SAKAGHEIQN GLSNRGFEVT
210 220 230 240 250
RLNTYTTVSV QDVDPLILKP ALSAPVVAVA SPSALRAWLN LASQVDNWGN
260 270 280 290 300
AIACIGETTA SAAKKFGLKS IYYPTTPGLD GWVESILEAL RAHGQSKEAP

GC
Length:302
Mass (Da):32,123
Last modified:August 22, 2006 - v1
Checksum:iE9964659A861998B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000009 Genomic DNA. Translation: ABF94358.1.
AP008209 Genomic DNA. Translation: BAF11115.1.
AP014959 Genomic DNA. Translation: BAS82675.1.
AK107127 mRNA. Translation: BAG97962.1.
RefSeqiXP_015630608.1. XM_015775122.1.
UniGeneiOs.31563.

Genome annotation databases

EnsemblPlantsiOS03T0186100-01; OS03T0186100-01; OS03G0186100.
GeneIDi4331869.
GrameneiOS03T0186100-01; OS03T0186100-01; OS03G0186100.
KEGGiosa:4331869.

Similar proteinsi

Entry informationi

Entry nameiHEM4_ORYSJ
AccessioniPrimary (citable) accession number: Q10QR9
Secondary accession number(s): A0A0P0VU16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: August 22, 2006
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families