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Q10QR9

- HEM4_ORYSJ

UniProt

Q10QR9 - HEM4_ORYSJ

Protein

Uroporphyrinogen-III synthase, chloroplastic

Gene

UROS

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, a precursor of tetrapyrroles such as chlorophyll, heme and phycobilins.By similarity

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-KW
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    3. uroporphyrinogen III biosynthetic process Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00320.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III synthase, chloroplastic (EC:4.2.1.75)
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:UROS
    Synonyms:HEMD
    Ordered Locus Names:Os03g0186100, LOC_Os03g08730
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 3

    Organism-specific databases

    GrameneiQ10QR9.

    Subcellular locationi

    Plastidchloroplast By similarity

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5050ChloroplastSequence AnalysisAdd
    BLAST
    Chaini51 – 302252Uroporphyrinogen-III synthase, chloroplasticPRO_0000376068Add
    BLAST

    Proteomic databases

    PaxDbiQ10QR9.
    PRIDEiQ10QR9.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG117493.
    KOiK01719.
    OMAiWIIITSP.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10QR9-1 [UniParc]FASTAAdd to Basket

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    MALSSSSHLL PFSRPPATFP RARHAGGGRG RAGATGRFIA CSSPPPPDVV    50
    VTRERGKNAK LIAALEKHNV QSLELPLIKH VEGPDTDRLS AVLRDEKFDW 100
    ITITSPEAAA VFLEGWKAAG NPKVRIAVVG AGTERVFDEV IQYNDGSLEV 150
    AFSPSKAMGK FLASELPRTT ETTCKVLYPA SAKAGHEIQN GLSNRGFEVT 200
    RLNTYTTVSV QDVDPLILKP ALSAPVVAVA SPSALRAWLN LASQVDNWGN 250
    AIACIGETTA SAAKKFGLKS IYYPTTPGLD GWVESILEAL RAHGQSKEAP 300
    GC 302
    Length:302
    Mass (Da):32,123
    Last modified:August 22, 2006 - v1
    Checksum:iE9964659A861998B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000009 Genomic DNA. Translation: ABF94358.1.
    AP008209 Genomic DNA. Translation: BAF11115.1.
    AK107127 mRNA. Translation: BAG97962.1.
    RefSeqiNP_001049201.1. NM_001055736.1.
    UniGeneiOs.31563.

    Genome annotation databases

    EnsemblPlantsiOS03T0186100-01; OS03T0186100-01; OS03G0186100.
    GeneIDi4331869.
    KEGGiosa:4331869.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000009 Genomic DNA. Translation: ABF94358.1 .
    AP008209 Genomic DNA. Translation: BAF11115.1 .
    AK107127 mRNA. Translation: BAG97962.1 .
    RefSeqi NP_001049201.1. NM_001055736.1.
    UniGenei Os.31563.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q10QR9.
    PRIDEi Q10QR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS03T0186100-01 ; OS03T0186100-01 ; OS03G0186100 .
    GeneIDi 4331869.
    KEGGi osa:4331869.

    Organism-specific databases

    Gramenei Q10QR9.

    Phylogenomic databases

    eggNOGi NOG117493.
    KOi K01719.
    OMAi WIIITSP.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
      The rice chromosome 3 sequencing consortium
      Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
      , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
      Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiHEM4_ORYSJ
    AccessioniPrimary (citable) accession number: Q10QR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3