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Q10QR9

- HEM4_ORYSJ

UniProt

Q10QR9 - HEM4_ORYSJ

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Protein

Uroporphyrinogen-III synthase, chloroplastic

Gene

UROS

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, a precursor of tetrapyrroles such as chlorophyll, heme and phycobilins.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-KW
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
  3. uroporphyrinogen III biosynthetic process Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase, chloroplastic (EC:4.2.1.75)
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:UROS
Synonyms:HEMD
Ordered Locus Names:Os03g0186100, LOC_Os03g08730
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ10QR9.

Subcellular locationi

Plastidchloroplast By similarity

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5050ChloroplastSequence AnalysisAdd
BLAST
Chaini51 – 302252Uroporphyrinogen-III synthase, chloroplasticPRO_0000376068Add
BLAST

Proteomic databases

PaxDbiQ10QR9.
PRIDEiQ10QR9.

Expressioni

Gene expression databases

ExpressionAtlasiQ10QR9. baseline.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG117493.
InParanoidiQ10QR9.
KOiK01719.
OMAiWIIITSP.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10QR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSSSSHLL PFSRPPATFP RARHAGGGRG RAGATGRFIA CSSPPPPDVV
60 70 80 90 100
VTRERGKNAK LIAALEKHNV QSLELPLIKH VEGPDTDRLS AVLRDEKFDW
110 120 130 140 150
ITITSPEAAA VFLEGWKAAG NPKVRIAVVG AGTERVFDEV IQYNDGSLEV
160 170 180 190 200
AFSPSKAMGK FLASELPRTT ETTCKVLYPA SAKAGHEIQN GLSNRGFEVT
210 220 230 240 250
RLNTYTTVSV QDVDPLILKP ALSAPVVAVA SPSALRAWLN LASQVDNWGN
260 270 280 290 300
AIACIGETTA SAAKKFGLKS IYYPTTPGLD GWVESILEAL RAHGQSKEAP

GC
Length:302
Mass (Da):32,123
Last modified:August 22, 2006 - v1
Checksum:iE9964659A861998B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000009 Genomic DNA. Translation: ABF94358.1.
AP008209 Genomic DNA. Translation: BAF11115.1.
AK107127 mRNA. Translation: BAG97962.1.
RefSeqiNP_001049201.1. NM_001055736.1.
UniGeneiOs.31563.

Genome annotation databases

EnsemblPlantsiOS03T0186100-01; OS03T0186100-01; OS03G0186100.
GeneIDi4331869.
KEGGiosa:4331869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000009 Genomic DNA. Translation: ABF94358.1 .
AP008209 Genomic DNA. Translation: BAF11115.1 .
AK107127 mRNA. Translation: BAG97962.1 .
RefSeqi NP_001049201.1. NM_001055736.1.
UniGenei Os.31563.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q10QR9.
PRIDEi Q10QR9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS03T0186100-01 ; OS03T0186100-01 ; OS03G0186100 .
GeneIDi 4331869.
KEGGi osa:4331869.

Organism-specific databases

Gramenei Q10QR9.

Phylogenomic databases

eggNOGi NOG117493.
InParanoidi Q10QR9.
KOi K01719.
OMAi WIIITSP.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .

Gene expression databases

ExpressionAtlasi Q10QR9. baseline.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHEM4_ORYSJ
AccessioniPrimary (citable) accession number: Q10QR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3