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Q10QA5

- D14_ORYSJ

UniProt

Q10QA5 - D14_ORYSJ

Protein

Probable strigolactone esterase D14

Gene

D14

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Involved in strigolactone signaling pathway. May function downstream of strigolactone synthesis, as a component of hormone signaling or as an enzyme that participates in the conversion of strigolactones to the bioactive form. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei147 – 1471NucleophileCurated
    Active sitei268 – 2681By similarity
    Active sitei297 – 2971By similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    GO - Biological processi

    1. secondary shoot formation Source: UniProtKB
    2. strigolactone biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable strigolactone esterase D14 (EC:3.1.-.-)
    Alternative name(s):
    Protein DWARF-14
    Protein DWARF-88
    Protein HIGH-TILLERING DWARF 2
    Gene namesi
    Name:D14
    Synonyms:D88, HTD2
    Ordered Locus Names:Os03g0203200, LOC_Os03g10620
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 3

    Organism-specific databases

    GrameneiQ10QA5.

    Pathology & Biotechi

    Disruption phenotypei

    Increased tillers and reduced plant height, elevated levels of strigolactones.4 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi79 – 791G → R in d88; dwarf and high tillering phenotypes. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Probable strigolactone esterase D14PRO_0000422054Add
    BLAST

    Proteomic databases

    PRIDEiQ10QA5.

    Expressioni

    Tissue specificityi

    Expressed in the parenchyma cells of the root stele and lateral roots, vascular tissues of vein and leaf sheath, ligule base, auricle base and stem base.2 Publications

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os03g10620.1.

    Structurei

    Secondary structure

    1
    318
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi56 – 594
    Beta strandi63 – 664
    Beta strandi69 – 757
    Helixi82 – 854
    Turni86 – 883
    Helixi89 – 913
    Turni92 – 954
    Beta strandi97 – 1004
    Helixi111 – 1133
    Helixi118 – 1203
    Helixi122 – 13514
    Beta strandi141 – 1466
    Helixi148 – 15912
    Turni161 – 1633
    Beta strandi164 – 1718
    Helixi188 – 20013
    Helixi202 – 21413
    Helixi219 – 23012
    Helixi234 – 24512
    Helixi250 – 2556
    Beta strandi260 – 2645
    Helixi274 – 2829
    Beta strandi287 – 2915
    Helixi299 – 3024
    Helixi304 – 31411

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VXKX-ray1.75A/B54-318[»]
    3W04X-ray1.45A/B55-318[»]
    3W05X-ray1.58A/B55-318[»]
    3WIOX-ray2.10A/B54-318[»]
    4IH9X-ray1.55A/B51-318[»]
    4IHAX-ray1.55A/B51-318[»]
    ProteinModelPortaliQ10QA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 5344Gly/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000251386.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q10QA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRSTHPPPS SPSSSSSGGG GGGGSSASSS SEKTMVGGGG GGGGGSGSAA    50
    PSGAKLLQIL NVRVVGSGER VVVLSHGFGT DQSAWSRVLP YLTRDHRVVL 100
    YDLVCAGSVN PDHFDFRRYD NLDAYVDDLL AILDALRIPR CAFVGHSVSA 150
    MIGILASIRR PDLFAKLVLI GASPRFLNDS DYHGGFELEE IQQVFDAMGA 200
    NYSAWATGYA PLAVGADVPA AVQEFSRTLF NMRPDISLHV CQTVFKTDLR 250
    GVLGMVRAPC VVVQTTRDVS VPASVAAYLK AHLGGRTTVE FLQTEGHLPH 300
    LSAPSLLAQV LRRALARY 318
    Length:318
    Mass (Da):33,508
    Last modified:August 22, 2006 - v1
    Checksum:i996A6044670563EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ406388 Genomic DNA. Translation: ACV30015.1.
    DP000009 Genomic DNA. Translation: ABF94525.1.
    DP000009 Genomic DNA. Translation: ABF94526.1.
    AP008209 Genomic DNA. Translation: BAF11220.1.
    AK070827 mRNA. Translation: BAG92161.1.
    RefSeqiNP_001049306.1. NM_001055841.1.
    UniGeneiOs.11186.

    Genome annotation databases

    EnsemblPlantsiOS03T0203200-01; OS03T0203200-01; OS03G0203200.
    GeneIDi4331983.
    KEGGiosa:4331983.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ406388 Genomic DNA. Translation: ACV30015.1 .
    DP000009 Genomic DNA. Translation: ABF94525.1 .
    DP000009 Genomic DNA. Translation: ABF94526.1 .
    AP008209 Genomic DNA. Translation: BAF11220.1 .
    AK070827 mRNA. Translation: BAG92161.1 .
    RefSeqi NP_001049306.1. NM_001055841.1.
    UniGenei Os.11186.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VXK X-ray 1.75 A/B 54-318 [» ]
    3W04 X-ray 1.45 A/B 55-318 [» ]
    3W05 X-ray 1.58 A/B 55-318 [» ]
    3WIO X-ray 2.10 A/B 54-318 [» ]
    4IH9 X-ray 1.55 A/B 51-318 [» ]
    4IHA X-ray 1.55 A/B 51-318 [» ]
    ProteinModelPortali Q10QA5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os03g10620.1.

    Proteomic databases

    PRIDEi Q10QA5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS03T0203200-01 ; OS03T0203200-01 ; OS03G0203200 .
    GeneIDi 4331983.
    KEGGi osa:4331983.

    Organism-specific databases

    Gramenei Q10QA5.

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000251386.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Dwarf 88, a novel putative esterase gene affecting architecture of rice plant."
      Gao Z., Qian Q., Liu X., Yan M., Feng Q., Dong G., Liu J., Han B.
      Plant Mol. Biol. 71:265-276(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, MUTAGENESIS OF GLY-79, DISRUPTION PHENOTYPE.
      Strain: cv. Lansheng.
    2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
      The rice chromosome 3 sequencing consortium
      Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
      , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
      Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.
    6. "Suppression of tiller bud activity in tillering dwarf mutants of rice."
      Ishikawa S., Maekawa M., Arite T., Onishi K., Takamure I., Kyozuka J.
      Plant Cell Physiol. 46:79-86(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
      Strain: cv. Shiokari.
    7. "DWARF10, an RMS1/MAX4/DAD1 ortholog, controls lateral bud outgrowth in rice."
      Arite T., Iwata H., Ohshima K., Maekawa M., Nakajima M., Kojima M., Sakakibara H., Kyozuka J.
      Plant J. 51:1019-1029(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
      Strain: cv. Shiokari.
    8. "d14, a strigolactone-insensitive mutant of rice, shows an accelerated outgrowth of tillers."
      Arite T., Umehara M., Ishikawa S., Hanada A., Maekawa M., Yamaguchi S., Kyozuka J.
      Plant Cell Physiol. 50:1416-1424(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    9. "The computational-based structure of Dwarf14 provides evidence for its role as potential strigolactone receptor in plants."
      Gaiji N., Cardinale F., Prandi C., Bonfante P., Ranghino G.
      BMC Res. Notes 5:307-307(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.
    10. "Structures of D14 and D14L in the strigolactone and karrikin signaling pathways."
      Kagiyama M., Hirano Y., Mori T., Kim S.Y., Kyozuka J., Seto Y., Yamaguchi S., Hakoshima T.
      Genes Cells 18:147-160(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 55-318 IN COMPLEX WITH INHIBITOR, FUNCTION.

    Entry informationi

    Entry nameiD14_ORYSJ
    AccessioniPrimary (citable) accession number: Q10QA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2013
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3