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Q10QA5

- D14_ORYSJ

UniProt

Q10QA5 - D14_ORYSJ

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Protein

Probable strigolactone esterase D14

Gene

D14

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in strigolactone signaling pathway. May function downstream of strigolactone synthesis, as a component of hormone signaling or as an enzyme that participates in the conversion of strigolactones to the bioactive form. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471NucleophileCurated
Active sitei268 – 2681By similarity
Active sitei297 – 2971By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  1. coumarin biosynthetic process Source: EnsemblPlants/Gramene
  2. proline transport Source: EnsemblPlants/Gramene
  3. response to wounding Source: EnsemblPlants/Gramene
  4. secondary shoot formation Source: UniProtKB
  5. strigolactone biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable strigolactone esterase D14 (EC:3.1.-.-)
Alternative name(s):
Protein DWARF-14
Protein DWARF-88
Protein HIGH-TILLERING DWARF 2
Gene namesi
Name:D14
Synonyms:D88, HTD2
Ordered Locus Names:Os03g0203200, LOC_Os03g10620
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ10QA5.

Pathology & Biotechi

Disruption phenotypei

Increased tillers and reduced plant height, elevated levels of strigolactones.4 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi79 – 791G → R in d88; dwarf and high tillering phenotypes. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Probable strigolactone esterase D14PRO_0000422054Add
BLAST

Proteomic databases

PRIDEiQ10QA5.

Expressioni

Tissue specificityi

Expressed in the parenchyma cells of the root stele and lateral roots, vascular tissues of vein and leaf sheath, ligule base, auricle base and stem base.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g10620.1.

Structurei

Secondary structure

1
318
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi56 – 594Combined sources
Beta strandi63 – 664Combined sources
Beta strandi69 – 757Combined sources
Helixi82 – 854Combined sources
Turni86 – 883Combined sources
Helixi89 – 913Combined sources
Turni92 – 954Combined sources
Beta strandi97 – 1004Combined sources
Helixi111 – 1133Combined sources
Helixi118 – 1203Combined sources
Helixi122 – 13514Combined sources
Beta strandi141 – 1466Combined sources
Helixi148 – 15912Combined sources
Turni161 – 1633Combined sources
Beta strandi164 – 1718Combined sources
Helixi188 – 20013Combined sources
Helixi202 – 21413Combined sources
Helixi219 – 23012Combined sources
Helixi234 – 24512Combined sources
Helixi250 – 2556Combined sources
Beta strandi260 – 2645Combined sources
Helixi274 – 2829Combined sources
Beta strandi287 – 2915Combined sources
Helixi299 – 3024Combined sources
Helixi304 – 31411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VXKX-ray1.75A/B54-318[»]
3W04X-ray1.45A/B55-318[»]
3W05X-ray1.58A/B55-318[»]
3WIOX-ray2.10A/B54-318[»]
4IH9X-ray1.55A/B51-318[»]
4IHAX-ray1.55A/B51-318[»]
ProteinModelPortaliQ10QA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 5344Gly/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000251386.
InParanoidiQ10QA5.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10QA5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRSTHPPPS SPSSSSSGGG GGGGSSASSS SEKTMVGGGG GGGGGSGSAA
60 70 80 90 100
PSGAKLLQIL NVRVVGSGER VVVLSHGFGT DQSAWSRVLP YLTRDHRVVL
110 120 130 140 150
YDLVCAGSVN PDHFDFRRYD NLDAYVDDLL AILDALRIPR CAFVGHSVSA
160 170 180 190 200
MIGILASIRR PDLFAKLVLI GASPRFLNDS DYHGGFELEE IQQVFDAMGA
210 220 230 240 250
NYSAWATGYA PLAVGADVPA AVQEFSRTLF NMRPDISLHV CQTVFKTDLR
260 270 280 290 300
GVLGMVRAPC VVVQTTRDVS VPASVAAYLK AHLGGRTTVE FLQTEGHLPH
310
LSAPSLLAQV LRRALARY
Length:318
Mass (Da):33,508
Last modified:August 22, 2006 - v1
Checksum:i996A6044670563EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ406388 Genomic DNA. Translation: ACV30015.1.
DP000009 Genomic DNA. Translation: ABF94525.1.
DP000009 Genomic DNA. Translation: ABF94526.1.
AP008209 Genomic DNA. Translation: BAF11220.1.
AK070827 mRNA. Translation: BAG92161.1.
RefSeqiNP_001049306.1. NM_001055841.1.
UniGeneiOs.11186.

Genome annotation databases

EnsemblPlantsiOS03T0203200-01; OS03T0203200-01; OS03G0203200.
GeneIDi4331983.
KEGGiosa:4331983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ406388 Genomic DNA. Translation: ACV30015.1 .
DP000009 Genomic DNA. Translation: ABF94525.1 .
DP000009 Genomic DNA. Translation: ABF94526.1 .
AP008209 Genomic DNA. Translation: BAF11220.1 .
AK070827 mRNA. Translation: BAG92161.1 .
RefSeqi NP_001049306.1. NM_001055841.1.
UniGenei Os.11186.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VXK X-ray 1.75 A/B 54-318 [» ]
3W04 X-ray 1.45 A/B 55-318 [» ]
3W05 X-ray 1.58 A/B 55-318 [» ]
3WIO X-ray 2.10 A/B 54-318 [» ]
4IH9 X-ray 1.55 A/B 51-318 [» ]
4IHA X-ray 1.55 A/B 51-318 [» ]
ProteinModelPortali Q10QA5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os03g10620.1.

Proteomic databases

PRIDEi Q10QA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS03T0203200-01 ; OS03T0203200-01 ; OS03G0203200 .
GeneIDi 4331983.
KEGGi osa:4331983.

Organism-specific databases

Gramenei Q10QA5.

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000251386.
InParanoidi Q10QA5.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dwarf 88, a novel putative esterase gene affecting architecture of rice plant."
    Gao Z., Qian Q., Liu X., Yan M., Feng Q., Dong G., Liu J., Han B.
    Plant Mol. Biol. 71:265-276(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, MUTAGENESIS OF GLY-79, DISRUPTION PHENOTYPE.
    Strain: cv. Lansheng.
  2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  6. "Suppression of tiller bud activity in tillering dwarf mutants of rice."
    Ishikawa S., Maekawa M., Arite T., Onishi K., Takamure I., Kyozuka J.
    Plant Cell Physiol. 46:79-86(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
    Strain: cv. Shiokari.
  7. "DWARF10, an RMS1/MAX4/DAD1 ortholog, controls lateral bud outgrowth in rice."
    Arite T., Iwata H., Ohshima K., Maekawa M., Nakajima M., Kojima M., Sakakibara H., Kyozuka J.
    Plant J. 51:1019-1029(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
    Strain: cv. Shiokari.
  8. "d14, a strigolactone-insensitive mutant of rice, shows an accelerated outgrowth of tillers."
    Arite T., Umehara M., Ishikawa S., Hanada A., Maekawa M., Yamaguchi S., Kyozuka J.
    Plant Cell Physiol. 50:1416-1424(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  9. "The computational-based structure of Dwarf14 provides evidence for its role as potential strigolactone receptor in plants."
    Gaiji N., Cardinale F., Prandi C., Bonfante P., Ranghino G.
    BMC Res. Notes 5:307-307(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  10. "Structures of D14 and D14L in the strigolactone and karrikin signaling pathways."
    Kagiyama M., Hirano Y., Mori T., Kim S.Y., Kyozuka J., Seto Y., Yamaguchi S., Hakoshima T.
    Genes Cells 18:147-160(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 55-318 IN COMPLEX WITH INHIBITOR, FUNCTION.

Entry informationi

Entry nameiD14_ORYSJ
AccessioniPrimary (citable) accession number: Q10QA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: August 22, 2006
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3