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Q10P01

- LCB1A_ORYSJ

UniProt

Q10P01 - LCB1A_ORYSJ

Protein

Long chain base biosynthesis protein 1a

Gene

Os03g0252800

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Serine palmitoyltransferase (SPT). The heterodimer formed with LCB2 constitutes the catalytic core By similarity.By similarity

    Catalytic activityi

    Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. cell growth Source: EnsemblPlants/Gramene
    3. regulation of programmed cell death Source: EnsemblPlants/Gramene
    4. sphingolipid metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_220105. Sphingolipid de novo biosynthesis.
    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long chain base biosynthesis protein 1a (EC:2.3.1.50)
    Gene namesi
    Ordered Locus Names:Os03g0252800, LOC_Os03g14800
    ORF Names:OsJ_10166
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 3

    Organism-specific databases

    GrameneiQ10P01.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Long chain base biosynthesis protein 1aPRO_0000419147Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer with LCB2. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1 and LCB2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi39946.BGIOSIBCE010384.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10P01.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000216602.
    KOiK00654.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q10P01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDMALPIVNA TAAVLARVSA AFNAPFARAV VFGVHIDGHL VVEGLLIAVI    50
    VFQLSRKSYK PPKKPLSEKE IDELCDEWEP EPLCPPIKDG ARIDTPMLES 100
    AAAPHTTIDG KEVINFASAN YLGLIGNEKI IDSCVGSLEK YGVGSCGPRG 150
    FYGTIDVHLD CEAKIAKFLG TPDSILYSYG ISTIFSVIPA FCKKGDIIVA 200
    DEGVHWAVQN GLHLSRSTVV YFKHNDMASL ANTLEKLTRG NKRAEKIRRY 250
    IVVESIYQNS GQIAPLDEIV RLKEKYRFRV ILEESHSFGV LGQSGRGLAE 300
    HYGVPIDKID IITAGMGNAL ATDGGFCTGS VRVVDHQRLS SSGYVFSASL 350
    PPYLASAAVS AVSYLEGNPS VLADLRSNIS FLHKELSGTP GLEISSHVLS 400
    PIVFLKLKKS TGSSNTDIDL LETIAERVLK EDSVFIVASK RSPLDRCKLP 450
    VGIRLFMSAG HTDSDISKVS SSLKRVSASV LSDYI 485
    Length:485
    Mass (Da):52,426
    Last modified:August 22, 2006 - v1
    Checksum:iCC3E17D2310E76CF
    GO

    Sequence cautioni

    The sequence ABF95003.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence ABF95004.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence ABF95005.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000009 Genomic DNA. Translation: ABF95002.1.
    DP000009 Genomic DNA. Translation: ABF95003.1. Sequence problems.
    DP000009 Genomic DNA. Translation: ABF95004.1. Sequence problems.
    DP000009 Genomic DNA. Translation: ABF95005.1. Sequence problems.
    AP008209 Genomic DNA. Translation: BAF11490.1.
    CM000140 Genomic DNA. Translation: EAZ26297.1.
    AK065537 mRNA. Translation: BAG89556.1.
    AK067765 mRNA. Translation: BAG90585.1.
    RefSeqiNP_001049576.1. NM_001056111.1.
    UniGeneiOs.8513.

    Genome annotation databases

    EnsemblPlantsiOS03T0252800-01; OS03T0252800-01; OS03G0252800.
    GeneIDi4332274.
    KEGGiosa:4332274.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000009 Genomic DNA. Translation: ABF95002.1 .
    DP000009 Genomic DNA. Translation: ABF95003.1 . Sequence problems.
    DP000009 Genomic DNA. Translation: ABF95004.1 . Sequence problems.
    DP000009 Genomic DNA. Translation: ABF95005.1 . Sequence problems.
    AP008209 Genomic DNA. Translation: BAF11490.1 .
    CM000140 Genomic DNA. Translation: EAZ26297.1 .
    AK065537 mRNA. Translation: BAG89556.1 .
    AK067765 mRNA. Translation: BAG90585.1 .
    RefSeqi NP_001049576.1. NM_001056111.1.
    UniGenei Os.8513.

    3D structure databases

    ProteinModelPortali Q10P01.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39946.BGIOSIBCE010384.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS03T0252800-01 ; OS03T0252800-01 ; OS03G0252800 .
    GeneIDi 4332274.
    KEGGi osa:4332274.

    Organism-specific databases

    Gramenei Q10P01.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000216602.
    KOi K00654.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    Reactomei REACT_220105. Sphingolipid de novo biosynthesis.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
      The rice chromosome 3 sequencing consortium
      Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
      , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
      Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLCB1A_ORYSJ
    AccessioniPrimary (citable) accession number: Q10P01
    Secondary accession number(s): Q10P00, Q10P02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2012
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3