Q10ND7 (LAC10_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Laccase-10
EC=1.10.3.2

Alternative name(s):
Benzenediol:oxygen oxidoreductase 10
Diphenol oxidase 10
Urishiol oxidase 10

Gene names

Name:	LAC10
Ordered Locus Names:	Os03g0273200, LOC_Os03g16610
ORF Names:	OsJ_009911

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Lignin degradation and detoxification of lignin-derived products By similarity.
Catalytic activity	4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.
Cofactor	Binds 4 copper ions per monomer By similarity.
Subcellular location	Secreted › extracellular space › apoplast Potential.
Sequence similarities	Belongs to the multicopper oxidase family. Contains 3 plastocyanin-like domains.

Ontologies

Keywords
Biological process	Lignin degradation
Cellular component	Apoplast Secreted
Domain	Repeat Signal
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lignin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	apoplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	copper ion binding Inferred from electronic annotation. Source: InterPro hydroquinone:oxygen oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 578	549	Laccase-10		PRO_0000291895
Regions
	Domain	37 – 153	117	Plastocyanin-like 1
	Domain	163 – 319	157	Plastocyanin-like 2
	Domain	428 – 562	135	Plastocyanin-like 3
Sites
	Metal binding	87	1	Copper 1 By similarity
	Metal binding	89	1	Copper 2 By similarity
	Metal binding	132	1	Copper 2 By similarity
	Metal binding	134	1	Copper 3 By similarity
	Metal binding	479	1	Copper 4 By similarity
	Metal binding	482	1	Copper 1 By similarity
	Metal binding	484	1	Copper 3 By similarity
	Metal binding	541	1	Copper 3 By similarity
	Metal binding	542	1	Copper 4 By similarity
	Metal binding	543	1	Copper 2 By similarity
	Metal binding	547	1	Copper 4 By similarity
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	83	1	N-linked (GlcNAc...) Potential
	Glycosylation	119	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Glycosylation	208	1	N-linked (GlcNAc...) Potential
	Glycosylation	244	1	N-linked (GlcNAc...) Potential
	Glycosylation	307	1	N-linked (GlcNAc...) Potential
	Glycosylation	336	1	N-linked (GlcNAc...) Potential
	Glycosylation	384	1	N-linked (GlcNAc...) Potential
	Glycosylation	392	1	N-linked (GlcNAc...) Potential
	Glycosylation	402	1	N-linked (GlcNAc...) Potential
	Glycosylation	438	1	N-linked (GlcNAc...) Potential
	Glycosylation	445	1	N-linked (GlcNAc...) Potential
	Glycosylation	448	1	N-linked (GlcNAc...) Potential
	Glycosylation	451	1	N-linked (GlcNAc...) Potential
	Glycosylation	461	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q10ND7 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 4493AA05FF1E36D7	FASTA	578	62,829
	10 20 30 40 50 60 MGARCLALLL LYGTLLLLLL LPQLPLAGAA TRYYTFNVKL QNVTRLCNTR AIPTVNGKFP 70 80 90 100 110 120 GPKIVTREGD RVVVKVVNNI KDNITIHWHG VRQMRTGWSD GPAYVTQCPI QTGQSYVYNF 130 140 150 160 170 180 TINGQRGTLF WHAHVSWLRS TLYGPIIILP KAGLPLPFTE PHKDVPIIFG EWFNADPEAI 190 200 210 220 230 240 VAQALQTGGG PNVSDAYTIN GLPGPLYNCS SKDTFRLKVQ PGKMYLLRLI NAALNDELFF 250 260 270 280 290 300 SVANHTLTVV DVDASYVKPF DTDVVLITPG QTTNVLLRAK PTAEAAGATH LMMARPYATG 310 320 330 340 350 360 RPGTYDNTTV AAVLEYAPPG HIKSLPLLRP SLPALNDTAF AAGFAAKLRS LACPDYPSNV 370 380 390 400 410 420 PRRVDKPFFF AVGLGTTPCP GSNNQTCQGP TNTTKFTASI NNVSFDMPTT ALLQAHYTGQ 430 440 450 460 470 480 SAGVYTADFP ASPLEPFNYT GTPPNNTNVS NGTRVVVLPY NASVEVVLQD TSILGAESHP 490 500 510 520 530 540 LHLHGFDFFV VGQGTGNYDP SKHPAEFNLV DPVQRNTVGV PAGGWVAIRF FADNPGVWFM 550 560 570 HCHLEVHTTW GLKMAWVVND GPLPEQKLMP PPSDLPMC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species." The rice chromosome 3 sequencing consortium Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S. , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S. Genome Res. 15:1284-1291(2005) [PubMed: 16109971] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[5]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DP000009 Genomic DNA. Translation: ABF95230.1. AP008209 Genomic DNA. Translation: BAF11613.1. CM000140 Genomic DNA. No translation available. AK072397 mRNA. No translation available.
RefSeq	NP_001049699.1. NM_001056234.1.
UniGene	Os.5638.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q10ND7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os03g16610.1; LOC_Os03g16610.1; LOC_Os03g16610.
GeneID	4332400.
KEGG	osa:4332400.
Phylogenomic databases
GeneTree	EPGT00050000000260.
HOGENOM	HBG749556.
OMA	KIVTREG.
PhylomeDB	Q10ND7.
ProtClustDB	CLSN2693781.
Family and domain databases
InterPro	IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. IPR017761. Laccase. [Graphical view]
Gene3D	G3DSA:2.60.40.420. Cupredoxin. 3 hits.
PANTHER	PTHR11709:SF9. PTHR11709:SF9. 1 hit.
Pfam	PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 3 hits.
TIGRFAMs	TIGR03389. Laccase. 1 hit.
PROSITE	PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LAC10_ORYSJ

Accession

Primary (citable) accession number: Q10ND7
Secondary accession number(s): A3AGI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	August 22, 2006
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program