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Q10KF0

- PSA2_ORYSJ

UniProt

Q10KF0 - PSA2_ORYSJ

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Protein

Proteasome subunit alpha type-2

Gene

PAB1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
REACT_212204. Separation of Sister Chromatids.
REACT_214064. ER-Phagosome pathway.
REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_229639. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_233422. Ubiquitin-dependent degradation of Cyclin D1.
REACT_235410. CDK-mediated phosphorylation and removal of Cdc6.
REACT_243301. Autodegradation of Cdh1 by Cdh1:APC/C.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-2 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit B
20S proteasome subunit alpha-2
Gene namesi
Name:PAB1
Ordered Locus Names:Os03g0387100, LOC_Os03g26970
ORF Names:OSJNBb0058G04.11
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ10KF0.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Proteasome subunit alpha type-2PRO_0000124087Add
BLAST

Proteomic databases

PRIDEiQ10KF0.

Expressioni

Gene expression databases

ExpressionAtlasiQ10KF0. baseline.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ10KF0.
SMRiQ10KF0. Positions 6-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
InParanoidiQ10KF0.
KOiK02726.
OMAiWKATALG.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10KF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDSQYSFSL TTFSPSGKLV QIEHALTAVG SGQTSLGIKA ANGVVIATEK
60 70 80 90 100
KLPSILVDET SVQKIQSLTP NIGVVYSGMG PDFRVLVRKS RKQAQQYYRL
110 120 130 140 150
YKETIPVTQL VRETAAVMQE FTQSGGVRPF GVSLLIAGYD DNGPQLYQVD
160 170 180 190 200
PSGSYFSWKA SAMGKNVSNA KTFLEKRYTE DMELDDAIHT AILTLKEGYE
210 220 230
GQISANNIEI GIIRSDREFK VLSPAEIKDF LEEVE
Length:235
Mass (Da):25,844
Last modified:August 22, 2006 - v1
Checksum:iD98998C0BC6CD676
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026559 mRNA. Translation: BAA96830.1.
AC103551 Genomic DNA. Translation: AAT78811.1.
DP000009 Genomic DNA. Translation: ABF96319.1.
AP008209 Genomic DNA. Translation: BAF12173.1.
RefSeqiNP_001050259.1. NM_001056794.1.
UniGeneiOs.7900.

Genome annotation databases

EnsemblPlantsiOS03T0387100-01; OS03T0387100-01; OS03G0387100.
GeneIDi4333000.
KEGGiosa:4333000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026559 mRNA. Translation: BAA96830.1 .
AC103551 Genomic DNA. Translation: AAT78811.1 .
DP000009 Genomic DNA. Translation: ABF96319.1 .
AP008209 Genomic DNA. Translation: BAF12173.1 .
RefSeqi NP_001050259.1. NM_001056794.1.
UniGenei Os.7900.

3D structure databases

ProteinModelPortali Q10KF0.
SMRi Q10KF0. Positions 6-234.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q10KF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS03T0387100-01 ; OS03T0387100-01 ; OS03G0387100 .
GeneIDi 4333000.
KEGGi osa:4333000.

Organism-specific databases

Gramenei Q10KF0.

Phylogenomic databases

eggNOGi COG0638.
InParanoidi Q10KF0.
KOi K02726.
OMAi WKATALG.

Enzyme and pathway databases

Reactomei REACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
REACT_212204. Separation of Sister Chromatids.
REACT_214064. ER-Phagosome pathway.
REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_229639. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_233422. Ubiquitin-dependent degradation of Cyclin D1.
REACT_235410. CDK-mediated phosphorylation and removal of Cdc6.
REACT_243301. Autodegradation of Cdh1 by Cdh1:APC/C.

Gene expression databases

ExpressionAtlasi Q10KF0. baseline.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structural features of the 20S proteasome subunits of rice (Oryza sativa)."
    Sassa H., Oguchi S., Inoue T., Hirano H.
    Gene 250:61-66(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Nipponbare.
  2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPSA2_ORYSJ
AccessioniPrimary (citable) accession number: Q10KF0
Secondary accession number(s): O22539, Q6AVF6, Q9LSU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 22, 2006
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3