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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP, preventing uracil incorporation into DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ per trimer.By similarity

Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (DUT)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Magnesium; shared with trimeric partnersBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT
Ordered Locus Names:Os03g0669100, LOC_Os03g46640
ORF Names:OSJNBa0039O18.10
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004013671 – 171Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST171

Proteomic databases

PaxDbiQ10FF9.
PRIDEiQ10FF9.

Expressioni

Gene expression databases

GenevisibleiQ10FF9. OS.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os03g46640.1.

Structurei

3D structure databases

ProteinModelPortaliQ10FF9.
SMRiQ10FF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Phylogenomic databases

eggNOGiKOG3370. Eukaryota.
COG0756. LUCA.
HOGENOMiHOG000028966.
InParanoidiQ10FF9.
KOiK01520.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10FF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATATNGNAS AAAAAADSAV QEPPHKIAKV APLLKVKKLS ENAVLPSRGS
60 70 80 90 100
ALAAGYDLSS AAEVVVPARG KAMVPTDLSI AIPEGTYARV APRSGLALKH
110 120 130 140 150
SIDVGAGVID ADYRGPVGVI LFNHSDTDFA VKPGDRIAQM IIEVIVTPEV
160 170
AEVEDLDATV RGEGGFGSTG V
Length:171
Mass (Da):17,340
Last modified:August 22, 2006 - v1
Checksum:iA8B02A3D668C2ECD
GO

Sequence cautioni

The sequence AAP44642 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABF98100 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF12776 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133930 Genomic DNA. Translation: AAP44642.1. Sequence problems.
DP000009 Genomic DNA. Translation: ABF98100.1. Sequence problems.
DP000009 Genomic DNA. Translation: ABF98101.1.
AP008209 Genomic DNA. Translation: BAF12776.1. Sequence problems.
AP014959 Genomic DNA. No translation available.
RefSeqiXP_015628906.1. XM_015773420.1.
UniGeneiOs.59170.

Genome annotation databases

GeneIDi4333679.
KEGGiosa:4333679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133930 Genomic DNA. Translation: AAP44642.1. Sequence problems.
DP000009 Genomic DNA. Translation: ABF98100.1. Sequence problems.
DP000009 Genomic DNA. Translation: ABF98101.1.
AP008209 Genomic DNA. Translation: BAF12776.1. Sequence problems.
AP014959 Genomic DNA. No translation available.
RefSeqiXP_015628906.1. XM_015773420.1.
UniGeneiOs.59170.

3D structure databases

ProteinModelPortaliQ10FF9.
SMRiQ10FF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g46640.1.

Proteomic databases

PaxDbiQ10FF9.
PRIDEiQ10FF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4333679.
KEGGiosa:4333679.

Phylogenomic databases

eggNOGiKOG3370. Eukaryota.
COG0756. LUCA.
HOGENOMiHOG000028966.
InParanoidiQ10FF9.
KOiK01520.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Gene expression databases

GenevisibleiQ10FF9. OS.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDUT_ORYSJ
AccessioniPrimary (citable) accession number: Q10FF9
Secondary accession number(s): Q0DPR2, Q10FG0, Q7Y196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: August 22, 2006
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.