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Q10FF9

- DUT_ORYSJ

UniProt

Q10FF9 - DUT_ORYSJ

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP, preventing uracil incorporation into DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) per trimer.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi143 – 1431Magnesium; shared with trimeric partnersBy similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: EnsemblPlants/Gramene

GO - Biological processi

  1. DNA-dependent DNA replication Source: EnsemblPlants/Gramene
  2. DNA repair Source: EnsemblPlants/Gramene
  3. dUMP biosynthetic process Source: UniProtKB-UniPathway
  4. dUTP metabolic process Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_230742. Pyrimidine biosynthesis.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT
Ordered Locus Names:Os03g0669100, LOC_Os03g46640
ORF Names:OSJNBa0039O18.10
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ10FF9.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000401367Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ10FF9. baseline.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os03g46640.1.

Structurei

3D structure databases

ProteinModelPortaliQ10FF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Phylogenomic databases

eggNOGiCOG0756.
HOGENOMiHOG000028966.
InParanoidiQ10FF9.
KOiK01520.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10FF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATATNGNAS AAAAAADSAV QEPPHKIAKV APLLKVKKLS ENAVLPSRGS
60 70 80 90 100
ALAAGYDLSS AAEVVVPARG KAMVPTDLSI AIPEGTYARV APRSGLALKH
110 120 130 140 150
SIDVGAGVID ADYRGPVGVI LFNHSDTDFA VKPGDRIAQM IIEVIVTPEV
160 170
AEVEDLDATV RGEGGFGSTG V
Length:171
Mass (Da):17,340
Last modified:August 22, 2006 - v1
Checksum:iA8B02A3D668C2ECD
GO

Sequence cautioni

The sequence AAP44642.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence ABF98100.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAF12776.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133930 Genomic DNA. Translation: AAP44642.1. Sequence problems.
DP000009 Genomic DNA. Translation: ABF98100.1. Sequence problems.
DP000009 Genomic DNA. Translation: ABF98101.1.
AP008209 Genomic DNA. Translation: BAF12776.1. Sequence problems.
RefSeqiNP_001050862.1. NM_001057397.1.
UniGeneiOs.59170.

Genome annotation databases

GeneIDi4333679.
KEGGiosa:4333679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133930 Genomic DNA. Translation: AAP44642.1 . Sequence problems.
DP000009 Genomic DNA. Translation: ABF98100.1 . Sequence problems.
DP000009 Genomic DNA. Translation: ABF98101.1 .
AP008209 Genomic DNA. Translation: BAF12776.1 . Sequence problems.
RefSeqi NP_001050862.1. NM_001057397.1.
UniGenei Os.59170.

3D structure databases

ProteinModelPortali Q10FF9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os03g46640.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4333679.
KEGGi osa:4333679.

Organism-specific databases

Gramenei Q10FF9.

Phylogenomic databases

eggNOGi COG0756.
HOGENOMi HOG000028966.
InParanoidi Q10FF9.
KOi K01520.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
Reactomei REACT_230742. Pyrimidine biosynthesis.

Gene expression databases

ExpressionAtlasi Q10FF9. baseline.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiDUT_ORYSJ
AccessioniPrimary (citable) accession number: Q10FF9
Secondary accession number(s): Q0DPR2, Q10FG0, Q7Y196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: August 22, 2006
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3