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Protein

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Gene

PP2A2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi55Manganese 1By similarity1
Metal bindingi57Manganese 1By similarity1
Metal bindingi83Manganese 1By similarity1
Metal bindingi83Manganese 2By similarity1
Metal bindingi115Manganese 2By similarity1
Active sitei116Proton donorBy similarity1
Metal bindingi165Manganese 2By similarity1
Metal bindingi239Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-OSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-OSA-198753 ERK/MAPK targets
R-OSA-202670 ERKs are inactivated
R-OSA-69231 Cyclin D associated events in G1
R-OSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-OSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A2
Ordered Locus Names:Os03g0805300, LOC_Os03g59060
ORF Names:OsJ_012457, OSJNBb0015I02.15
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588621 – 307Serine/threonine-protein phosphatase PP2A-2 catalytic subunitAdd BLAST307

Proteomic databases

PaxDbiQ10BT5
PRIDEiQ10BT5

Expressioni

Gene expression databases

ExpressionAtlasiQ10BT5 differential
GenevisibleiQ10BT5 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g59060.1

Structurei

3D structure databases

ProteinModelPortaliQ10BT5
SMRiQ10BT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
InParanoidiQ10BT5
KOiK04382
OMAiNKIFCPH
OrthoDBiEOG09360EXD

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q10BT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPHGGLDD QIERLMQCKP LPEPEVRALC EKAKEILMEE SNVQPVKSPV
60 70 80 90 100
TICGDIHGQF HDLAELFRIG GKCPDTNYLF MGDYVDRGYY SVETVTLLVA
110 120 130 140 150
LKVRYPQRIT ILRGNHESRQ ITQVYGFYDE CLRKYGNANV WKTFTDLFDY
160 170 180 190 200
FPLTALVESE IFCLHGGLSP SIETLDNIRN FDRVQEVPHE GPMCDLLWSD
210 220 230 240 250
PDDRCGWGIS PRGAGYTFGQ DISEQFNHTN NLRLIARAHQ LVMEGFNWAH
260 270 280 290 300
EQKVVTIFSA PNYCYRCGNM ASILEVDDCR EHTFIQFEPA PRRGEPDVTR

RTPDYFL
Length:307
Mass (Da):35,243
Last modified:August 22, 2006 - v1
Checksum:iABD1A94EDDFAC2EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135563 Genomic DNA Translation: AAS07220.1
DP000009 Genomic DNA Translation: ABF99431.1
DP000009 Genomic DNA Translation: ABF99432.1
AP008209 Genomic DNA Translation: BAF13541.1
AP014959 Genomic DNA Translation: BAS86935.1
CM000140 Genomic DNA Translation: EAZ28974.1
AK060885 mRNA Translation: BAG87595.1
AK099257 mRNA Translation: BAG94025.1
AK100350 mRNA Translation: BAG94563.1
RefSeqiXP_015631518.1, XM_015776032.1
XP_015631519.1, XM_015776033.1
UniGeneiOs.9183

Genome annotation databases

EnsemblPlantsiOs03t0805300-01; Os03t0805300-01; Os03g0805300
GeneIDi4334494
GrameneiOs03t0805300-01; Os03t0805300-01; Os03g0805300
KEGGiosa:4334494

Entry informationi

Entry nameiPP2A2_ORYSJ
AccessioniPrimary (citable) accession number: Q10BT5
Secondary accession number(s): B7E5E8, Q75HI9, Q9XF94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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