PP2A2

Functionⁱ

Catalytic activityⁱ

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Cofactorⁱ

Mn²⁺By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	55	Manganese 1By similarity	1
Metal bindingⁱ	57	Manganese 1By similarity	1
Metal bindingⁱ	83	Manganese 1By similarity	1
Metal bindingⁱ	83	Manganese 2By similarity	1
Metal bindingⁱ	115	Manganese 2By similarity	1
Active siteⁱ	116	Proton donorBy similarity	1
Metal bindingⁱ	165	Manganese 2By similarity	1
Metal bindingⁱ	239	Manganese 2By similarity	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
phosphoprotein phosphatase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Ligand	Manganese, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC:3.1.3.16)
Gene namesⁱ	Name:PP2A2 Ordered Locus Names:Os03g0805300, LOC_Os03g59060 ORF Names:OsJ_012457, OSJNBb0015I02.15
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 3

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058862	1 – 307	Serine/threonine-protein phosphatase PP2A-2 catalytic subunitAdd BLAST		307

Proteomic databases

PaxDbⁱ	Q10BT5.

PaxDbⁱ

Q10BT5.

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q10BT5. baseline and differential.
Genevisibleⁱ	Q10BT5. OS.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os03g59060.1.

STRINGⁱ

39947.LOC_Os03g59060.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q10BT5.
SMRⁱ	Q10BT5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0371. Eukaryota. COG0639. LUCA.
InParanoidⁱ	Q10BT5.
KEGG Orthology (KO) More...KOⁱ	K04382.
OMAⁱ	NKIFCPH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360EXD.

Family and domain databases

Gene3Dⁱ	3.60.21.10. 1 hit.
InterProⁱ	View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR006186. Ser/Thr-sp_prot-phosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit.
PRINTSⁱ	PR00114. STPHPHTASE.
SMARTⁱ	View protein in SMART SM00156. PP2Ac. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q10BT5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSPHGGLDD QIERLMQCKP LPEPEVRALC EKAKEILMEE SNVQPVKSPV 
        60         70         80         90        100
TICGDIHGQF HDLAELFRIG GKCPDTNYLF MGDYVDRGYY SVETVTLLVA 
       110        120        130        140        150
LKVRYPQRIT ILRGNHESRQ ITQVYGFYDE CLRKYGNANV WKTFTDLFDY 
       160        170        180        190        200
FPLTALVESE IFCLHGGLSP SIETLDNIRN FDRVQEVPHE GPMCDLLWSD 
       210        220        230        240        250
PDDRCGWGIS PRGAGYTFGQ DISEQFNHTN NLRLIARAHQ LVMEGFNWAH 
       260        270        280        290        300
EQKVVTIFSA PNYCYRCGNM ASILEVDDCR EHTFIQFEPA PRRGEPDVTR 

RTPDYFL

Length:307

Mass (Da):35,243

Last modified:August 22, 2006 - v1

Checksum:ⁱABD1A94EDDFAC2EE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC135563 Genomic DNA. Translation: AAS07220.1. DP000009 Genomic DNA. Translation: ABF99431.1. DP000009 Genomic DNA. Translation: ABF99432.1. AP008209 Genomic DNA. Translation: BAF13541.1. AP014959 Genomic DNA. Translation: BAS86935.1. CM000140 Genomic DNA. Translation: EAZ28974.1. AK060885 mRNA. Translation: BAG87595.1. AK099257 mRNA. Translation: BAG94025.1. AK100350 mRNA. Translation: BAG94563.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015631518.1. XM_015776032.1. XP_015631519.1. XM_015776033.1.
UniGeneⁱ	Os.9183.

Genome annotation databases

EnsemblPlantsⁱ	Os03t0805300-01; Os03t0805300-01; Os03g0805300.
GeneIDⁱ	4334494.
Grameneⁱ	Os03t0805300-01; Os03t0805300-01; Os03g0805300.
KEGGⁱ	osa:4334494.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q10BT5	A2XN40 A0A0E0KKE8 I1PGH2 A0A1E5UL43 A0A0E0D8I2 A0A0E0P2S7	Oryza sativa subsp. indica (Rice) Oryza punctata (Red rice) Oryza glaberrima (African rice) Dichanthelium oligosanthes Oryza meridionalis Oryza rufipogon (Brownbeard rice) (Asian wild rice)	307	UniRef100_A2XN40	Cluster: Serine/threonine-protein phosphatase PP2A-2 catalytic subunit	7

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q10BT5	A2XN40 A0A0E0KKE8 I1PGH2 A0A1E5UL43 A0A0E0D8I2 A0A0E0P2S7 A0A0E0GV72 A0A0D9ZEN9 A0A0D3FQE0 A0A0E0GV73 +19	Oryza sativa subsp. indica (Rice) Oryza punctata (Red rice) Oryza glaberrima (African rice) Dichanthelium oligosanthes Oryza meridionalis Oryza rufipogon (Brownbeard rice) (Asian wild rice) Oryza nivara (Indian wild rice) Oryza glumipatula Oryza barthii Brachypodium distachyon (Purple false brome) (Trachynia distachya) And more	307	UniRef90_A2XN40	Cluster: Serine/threonine-protein phosphatase PP2A-2 catalytic subunit	30

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q10BT5	P63330 P63331 F0X375 A0A1U7QHY3 Q5MKL3 L5JVK6 L5MJJ5 UPI000529F9A2 UPI000661F7BA Q6P365 +1223	Mus musculus (Mouse) Rattus norvegicus (Rat) Cricetidae sp. (Hamster) Mesocricetus auratus (Golden hamster) Pteropus alecto (Black flying fox) Myotis davidii (David's myotis) Chlamydotis macqueenii (Macqueen's bustard) Melopsittacus undulatus (Budgerigar) (Psittacus undulatus) Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Gavialis gangeticus (Indian gharial) And more	309	UniRef50_P63330	Cluster: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	1,234

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC135563 Genomic DNA. Translation: AAS07220.1. DP000009 Genomic DNA. Translation: ABF99431.1. DP000009 Genomic DNA. Translation: ABF99432.1. AP008209 Genomic DNA. Translation: BAF13541.1. AP014959 Genomic DNA. Translation: BAS86935.1. CM000140 Genomic DNA. Translation: EAZ28974.1. AK060885 mRNA. Translation: BAG87595.1. AK099257 mRNA. Translation: BAG94025.1. AK100350 mRNA. Translation: BAG94563.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015631518.1. XM_015776032.1. XP_015631519.1. XM_015776033.1.
UniGeneⁱ	Os.9183.

3D structure databases

ProteinModelPortalⁱ	Q10BT5.
SMRⁱ	Q10BT5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os03g59060.1.

STRINGⁱ

39947.LOC_Os03g59060.1.

Proteomic databases

PaxDbⁱ	Q10BT5.

PaxDbⁱ

Q10BT5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	Os03t0805300-01; Os03t0805300-01; Os03g0805300.
GeneIDⁱ	4334494.
Grameneⁱ	Os03t0805300-01; Os03t0805300-01; Os03g0805300.
KEGGⁱ	osa:4334494.

Phylogenomic databases

eggNOGⁱ	KOG0371. Eukaryota. COG0639. LUCA.
InParanoidⁱ	Q10BT5.
KEGG Orthology (KO) More...KOⁱ	K04382.
OMAⁱ	NKIFCPH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360EXD.

Gene expression databases

ExpressionAtlasⁱ	Q10BT5. baseline and differential.
Genevisibleⁱ	Q10BT5. OS.

Family and domain databases

Gene3Dⁱ	3.60.21.10. 1 hit.
InterProⁱ	View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR006186. Ser/Thr-sp_prot-phosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit.
PRINTSⁱ	PR00114. STPHPHTASE.
SMARTⁱ	View protein in SMART SM00156. PP2Ac. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00125. SER_THR_PHOSPHATASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PP2A2_ORYSJ
Accessionⁱ	Q10BT5Primary (citable) accession number: Q10BT5 Secondary accession number(s): B7E5E8, Q75HI9, Q9XF94
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	August 22, 2006
	Last modified:	March 28, 2018
	This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q10BT5 (PP2A2_ORYSJ)

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Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ