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Protein

Galactoside 2-alpha-L-fucosyltransferase 2

Gene

Fut2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Creates a membrane-associated precursor oligosaccharide Fuc-alpha((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the membrane-associated A and B antigen synthesis pathway.1 Publication

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • galactoside 2-alpha-L-fucosyltransferase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.69. 5301.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Chemistry

SwissLipidsiSLP:000000796.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 2 (EC:2.4.1.69)
Alternative name(s):
Alpha 1,2-fucosyltransferase
Alpha 1,2-fucosyltransferase B
Alpha 1-2 fucosyltransferase
Alpha(1,2)FT 2
Fucosyltransferase 2
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
Secretor blood group alpha-2-fucosyltransferase
Gene namesi
Name:Fut2
Synonyms:Ftb, Sec1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2639. Fut2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence analysis
Transmembranei6 – 2621Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini27 – 354328LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Galactoside 2-alpha-L-fucosyltransferase 2PRO_0000149114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ10984.
PRIDEiQ10984.

Expressioni

Tissue specificityi

Specifically expressed in gut.1 Publication

Gene expression databases

BgeeiENSRNOG00000021011.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028519.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 11 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
HOGENOMiHOG000261621.
HOVERGENiHBG004338.
InParanoidiQ10984.
KOiK00718.
PhylomeDBiQ10984.
TreeFamiTF315810.

Family and domain databases

InterProiIPR002516. Glyco_trans_11.
[Graphical view]
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiPF01531. Glyco_transf_11. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q10984-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASAQVPFSF PLAHFLIFVF VTSTITHLQQ RIVKLQPLSE KELPMTTQMS
60 70 80 90 100
SGNTESPEMR RDSEQHGNGE LRGMFTINSI GRLGNQMGEY ATLFALARMN
110 120 130 140 150
GRLAFIPASM HNALAPIFRI SLPVLHSDTA KKIPWQNYHL NDWMEERYRH
160 170 180 190 200
IPGHFVRFTG YPCSWTFYHH LRPEILKEFT LHDHVREEAQ AFLRGLRVNG
210 220 230 240 250
SQPSTFVGVH VRRGDYVHVM PNVWKGVVAD RGYLEKALDM FRARYSSPVF
260 270 280 290 300
VVTSNGMAWC RENINASRGD VVFAGNGIEG SPAKDFALLT QCNHTIMTIG
310 320 330 340 350
TFGIWAAYLA GGDTIYLANY TLPDSPFLKV FKPEAAFLPE WVGIPADLSP

LLKH
Length:354
Mass (Da):39,983
Last modified:December 6, 2005 - v2
Checksum:i123E8C8379E8559E
GO
Isoform 2 (identifier: Q10984-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: H → ALTPACPRSHFHLKAKGVTCYVAGRAF

Show »
Length:380
Mass (Da):42,730
Checksum:i8183786AE8212EBE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → I (PubMed:11341836).Curated
Sequence conflicti26 – 261T → I (Ref. 3) Curated
Sequence conflicti271 – 2711V → G in AAB41515 (PubMed:8010942).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei354 – 3541H → ALTPACPRSHFHLKAKGVTC YVAGRAF in isoform 2. 2 PublicationsVSP_016526

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264005 mRNA. Translation: AAF72200.1.
AF131238 Genomic DNA. Translation: AAD24469.1.
AB006138 mRNA. Translation: BAA21742.1.
L26010 mRNA. Translation: AAB41515.1.
PIRiS46494.
RefSeqiNP_113823.1. NM_031635.1.
XP_006229192.1. XM_006229130.2.
XP_006229197.1. XM_006229135.2.
XP_006229198.1. XM_006229136.2.
XP_006229199.1. XM_006229137.2.
XP_006229200.1. XM_006229138.2.
XP_006229201.1. XM_006229139.2.
XP_006229202.1. XM_006229140.2.
XP_006229203.1. XM_006229141.2.
XP_008757634.1. XM_008759412.1.
UniGeneiRn.10678.

Genome annotation databases

GeneIDi58924.
KEGGirno:58924.
UCSCiRGD:2639. rat. [Q10984-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264005 mRNA. Translation: AAF72200.1.
AF131238 Genomic DNA. Translation: AAD24469.1.
AB006138 mRNA. Translation: BAA21742.1.
L26010 mRNA. Translation: AAB41515.1.
PIRiS46494.
RefSeqiNP_113823.1. NM_031635.1.
XP_006229192.1. XM_006229130.2.
XP_006229197.1. XM_006229135.2.
XP_006229198.1. XM_006229136.2.
XP_006229199.1. XM_006229137.2.
XP_006229200.1. XM_006229138.2.
XP_006229201.1. XM_006229139.2.
XP_006229202.1. XM_006229140.2.
XP_006229203.1. XM_006229141.2.
XP_008757634.1. XM_008759412.1.
UniGeneiRn.10678.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028519.

Chemistry

SwissLipidsiSLP:000000796.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Proteomic databases

PaxDbiQ10984.
PRIDEiQ10984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58924.
KEGGirno:58924.
UCSCiRGD:2639. rat. [Q10984-1]

Organism-specific databases

CTDi2524.
RGDi2639. Fut2.

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
HOGENOMiHOG000261621.
HOVERGENiHBG004338.
InParanoidiQ10984.
KOiK00718.
PhylomeDBiQ10984.
TreeFamiTF315810.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.69. 5301.

Miscellaneous databases

PROiQ10984.

Gene expression databases

BgeeiENSRNOG00000021011.

Family and domain databases

InterProiIPR002516. Glyco_trans_11.
[Graphical view]
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiPF01531. Glyco_transf_11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUT2_RAT
AccessioniPrimary (citable) accession number: Q10984
Secondary accession number(s): O35087, Q9JK44, Q9R275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In rat, there are three genes (Fut1/Fta, Fut2/Ftb and Ftc) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner and Ftc may have no enzymatic activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.