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Protein

Galactoside 2-alpha-L-fucosyltransferase 2

Gene

FUT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).5 Publications

Miscellaneous

There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R.1 Publication
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.1 Publication

Kineticsi

  1. KM=11.5 mM for phenyl-beta-D-galactoside1 Publication
  2. KM=3.6 mM for lacto-N-biose1 Publication
  3. KM=3.8 mM for N-acetyllactosamine1 Publication
  4. KM=197 µM for GDP-fucose1 Publication

    Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    GO - Molecular functioni

    • fucosyltransferase activity Source: ProtInc
    • galactoside 2-alpha-L-fucosyltransferase activity Source: UniProtKB

    GO - Biological processi

    • carbohydrate metabolic process Source: ProtInc
    • L-fucose catabolic process Source: UniProtKB
    • protein glycosylation Source: UniProtKB

    Keywordsi

    Molecular functionBlood group antigen, Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMetaCyc:HS11104-MONOMER
    BRENDAi2.4.1.69 2681
    SIGNORiQ10981
    UniPathwayiUPA00378

    Protein family/group databases

    CAZyiGT11 Glycosyltransferase Family 11

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 2 (EC:2.4.1.3441 Publication, EC:2.4.1.691 Publication)
    Alternative name(s):
    Alpha(1,2)FT 2
    Fucosyltransferase 2
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
    SE2
    Secretor blood group alpha-2-fucosyltransferase
    Secretor factor
    Short name:
    Se
    Gene namesi
    Name:FUT2
    Synonyms:SEC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 19

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000176920.11
    HGNCiHGNC:4013 FUT2
    MIMi182100 gene+phenotype
    neXtProtiNX_Q10981

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
    Transmembranei15 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST14
    Topological domaini29 – 343LumenalSequence analysisAdd BLAST315

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi2524
    MalaCardsiFUT2
    MIMi182100 gene+phenotype
    612542 phenotype
    OpenTargetsiENSG00000176920
    PharmGKBiPA28429

    Polymorphism and mutation databases

    BioMutaiFUT2
    DMDMi1730125

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000121401 – 343Galactoside 2-alpha-L-fucosyltransferase 2Add BLAST343

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ10981
    PeptideAtlasiQ10981
    PRIDEiQ10981

    PTM databases

    iPTMnetiQ10981
    PhosphoSitePlusiQ10981

    Expressioni

    Tissue specificityi

    Small intestine, colon and lung.

    Gene expression databases

    BgeeiENSG00000176920
    CleanExiHS_FUT2
    ExpressionAtlasiQ10981 baseline and differential
    GenevisibleiQ10981 HS

    Organism-specific databases

    HPAiHPA014402

    Interactioni

    Protein-protein interaction databases

    BioGridi108800, 1 interactor
    IntActiQ10981, 1 interactor
    STRINGi9606.ENSP00000375748

    Structurei

    3D structure databases

    ProteinModelPortaliQ10981
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 11 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiENOG410IFKR Eukaryota
    ENOG4111HG3 LUCA
    GeneTreeiENSGT00390000001450
    HOGENOMiHOG000261621
    HOVERGENiHBG004338
    InParanoidiQ10981
    KOiK00718
    OMAiAFLPEWT
    OrthoDBiEOG091G0X2P
    PhylomeDBiQ10981
    TreeFamiTF315810

    Family and domain databases

    InterProiView protein in InterPro
    IPR002516 Glyco_trans_11
    PANTHERiPTHR11927 PTHR11927, 1 hit
    PfamiView protein in Pfam
    PF01531 Glyco_transf_11, 1 hit

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

    Isoform Long (identifier: Q10981-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS
    60 70 80 90 100
    TSKALGPSQL RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH
    110 120 130 140 150
    STLAPIFRIT LPVLHSATAS RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY
    160 170 180 190 200
    PCSWTFYHHL RQEILQEFTL HDHVREEAQK FLRGLQVNGS RPGTFVGVHV
    210 220 230 240 250
    RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSLIFV VTSNGMAWCR
    260 270 280 290 300
    ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG
    310 320 330 340
    GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH
    Length:343
    Mass (Da):39,017
    Last modified:October 1, 1996 - v1
    Checksum:i12066D9CF175E13A
    GO
    Isoform Short (identifier: Q10981-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.

    Show »
    Length:332
    Mass (Da):37,740
    Checksum:i96DE97ED89807A8A
    GO

    Sequence cautioni

    The sequence BAA11638 differs from that shown. Reason: Erroneous initiation.Curated

    Polymorphismi

    Three alleles have been identified in the Japanese population: Se1, Se2, and Sej.1 Publication
    Common polymorphisms in FUT2 define the vitamin B12 plasma level quantitative trait locus 1 (B12QTL1) [MIMi:612542]. Vitamin B12 found in meat and milk products is necessary for the formation of red blood cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodegenerative disorders, is often related to poor intestinal B12 absorption rather than direct dietary deficiency.1 Publication
    Genetic variation in FUT2 results in the non-secretor phenotype which gives rise to non-functional FUT2, resulting in a lack of the H type-1 oligosaccharide ligand in secretions, and this prevents Norwalk virus binding contributing to resistance to Norwalk virus infection.1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_00342225I → V Polymorphism found in Xhosa population. 2 PublicationsCorresponds to variant dbSNP:rs1800021Ensembl.1
    Natural variantiVAR_003423138R → C Polymorphism found in Xhosa population. 2 PublicationsCorresponds to variant dbSNP:rs1800022Ensembl.1
    Natural variantiVAR_003424140I → F in allele Sej; non-secretor phenotype. 3 PublicationsCorresponds to variant dbSNP:rs1047781EnsemblClinVar.1
    Natural variantiVAR_003425172D → N Polymorphism found in Xhosa population. 2 PublicationsCorresponds to variant dbSNP:rs1800025Ensembl.1
    Natural variantiVAR_022187258G → S1 PublicationCorresponds to variant dbSNP:rs602662Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0187361 – 11Missing in isoform Short. CuratedAdd BLAST11

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U17894 Genomic DNA Translation: AAC24453.1
    D89327 Genomic DNA Translation: BAA13944.1
    D87942 mRNA Translation: BAA21684.1
    AY937240 Genomic DNA Translation: AAX14047.1
    BC121066 mRNA No translation available.
    D82933 Genomic DNA Translation: BAA11638.1 Different initiation.
    CCDSiCCDS33069.1 [Q10981-1]
    PIRiA56098
    RefSeqiNP_000502.4, NM_000511.5 [Q10981-1]
    NP_001091107.1, NM_001097638.2 [Q10981-1]
    UniGeneiHs.579928

    Genome annotation databases

    EnsembliENST00000391876; ENSP00000375748; ENSG00000176920 [Q10981-1]
    ENST00000425340; ENSP00000387498; ENSG00000176920 [Q10981-1]
    GeneIDi2524
    KEGGihsa:2524
    UCSCiuc010emc.4 human [Q10981-1]

    Keywords - Coding sequence diversityi

    Alternative initiation, Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiFUT2_HUMAN
    AccessioniPrimary (citable) accession number: Q10981
    Secondary accession number(s): Q0VAG5, Q14338, Q5D0G2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: May 23, 2018
    This is version 165 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. SIMILARITY comments
      Index of protein domains and families

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