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Protein

Galactoside 2-alpha-L-fucosyltransferase 1

Gene

Fut1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.69. 5301.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 1 (EC:2.4.1.69)
Alternative name(s):
Alpha 1,2-fucosyltransferase A
Alpha(1,2)FT 1
Fucosyltransferase 1
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
Gene namesi
Name:Fut1
Synonyms:Fta
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2638. Fut1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence analysisAdd
BLAST
Transmembranei13 – 2917Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini30 – 376347LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Galactoside 2-alpha-L-fucosyltransferase 1PRO_0000149102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence analysis
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ10980.
PRIDEiQ10980.

PTM databases

iPTMnetiQ10980.
PhosphoSiteiQ10980.

Expressioni

Gene expression databases

GenevisibleiQ10980. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028494.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 11 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
GeneTreeiENSGT00390000001450.
HOGENOMiHOG000261621.
HOVERGENiHBG004338.
InParanoidiQ10980.
KOiK00718.
OMAiFLHIHQD.
OrthoDBiEOG7C5M8F.
PhylomeDBiQ10980.
TreeFamiTF315810.

Family and domain databases

InterProiIPR002516. Glyco_trans_11.
[Graphical view]
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiPF01531. Glyco_transf_11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTPSRKQLC LAFLSVCVLS AGSFFFHLNG GNFFQNALTF SVLCPDYHLL
60 70 80 90 100
KSPVAMVCLP YPSNASSGSP SCPEQSLLSG TWTITPGGRF GNQMGQYATL
110 120 130 140 150
LALAQLNGRR AFIQPEMHTT LAPVFRISLP VLDPEVDSLT PWQHLVLHDW
160 170 180 190 200
MSEEYSHLED PFLKLSGFPC SWTFFHHLRE QIRREFTLHD HLREDAQRLL
210 220 230 240 250
SGLRIGPAGI RPRTYVGVHV RRGDYLEVMP NRWKGVVGDR AYLQKAMDWF
260 270 280 290 300
RARHKDPIFV VTSNGMRWCL ENIDTSHGDV VFAGNGQEGT PGKDFALLTQ
310 320 330 340 350
CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF RPKAAFLPEW
360 370
VGINADLSPL QAQFDPWETD SLFRLA
Length:376
Mass (Da):42,417
Last modified:July 15, 1999 - v2
Checksum:iC350C737C758B7F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015637 Genomic DNA. Translation: BAA31130.1.
AB006137 mRNA. Translation: BAA21741.1.
AF131237 Genomic DNA. Translation: AAD24468.1.
L26009 mRNA. Translation: AAB41514.1.
PIRiS51582.
RefSeqiNP_112515.1. NM_031236.1.
XP_008757642.1. XM_008759420.1.
UniGeneiRn.11382.

Genome annotation databases

EnsembliENSRNOT00000028494; ENSRNOP00000028494; ENSRNOG00000020995.
GeneIDi81919.
KEGGirno:81919.
UCSCiRGD:2638. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015637 Genomic DNA. Translation: BAA31130.1.
AB006137 mRNA. Translation: BAA21741.1.
AF131237 Genomic DNA. Translation: AAD24468.1.
L26009 mRNA. Translation: AAB41514.1.
PIRiS51582.
RefSeqiNP_112515.1. NM_031236.1.
XP_008757642.1. XM_008759420.1.
UniGeneiRn.11382.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028494.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

PTM databases

iPTMnetiQ10980.
PhosphoSiteiQ10980.

Proteomic databases

PaxDbiQ10980.
PRIDEiQ10980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028494; ENSRNOP00000028494; ENSRNOG00000020995.
GeneIDi81919.
KEGGirno:81919.
UCSCiRGD:2638. rat.

Organism-specific databases

CTDi2523.
RGDi2638. Fut1.

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
GeneTreeiENSGT00390000001450.
HOGENOMiHOG000261621.
HOVERGENiHBG004338.
InParanoidiQ10980.
KOiK00718.
OMAiFLHIHQD.
OrthoDBiEOG7C5M8F.
PhylomeDBiQ10980.
TreeFamiTF315810.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.69. 5301.

Miscellaneous databases

PROiQ10980.

Gene expression databases

GenevisibleiQ10980. RN.

Family and domain databases

InterProiIPR002516. Glyco_trans_11.
[Graphical view]
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiPF01531. Glyco_transf_11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two distinct rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase genes."
    Soejima M., Wang B., Koda Y., Kimura H.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Colon cancer.
  2. "Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC."
    Bureau V., Marionneau S., Cailleau-Thomas A., Le Moullac-Vaidye B., Liehr T., Le Pendu J.
    Eur. J. Biochem. 268:1006-1019(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: BDIX.
  3. "Evidence for two distinct alpha(1,2)-fucosyltransferase genes differentially expressed throughout the rat colon."
    Piau J.-P., Labarriere N., Dabouis G., Denis M.G.
    Biochem. J. 300:623-626(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 169-310.
    Strain: BDIX.

Entry informationi

Entry nameiFUT1_RAT
AccessioniPrimary (citable) accession number: Q10980
Secondary accession number(s): Q549F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two genes (Fut1 and Fut2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.