Reviewed, UniProtKB/Swiss-Prot Q10979 (FUT1_RABIT)

Names and origin

Protein names

Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 1
    EC=2.4.1.69
Alternative name(s):
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
    Alpha(1,2)FT 1
    Fucosyltransferase 1

Gene names

Name:	FUT1
Synonyms:	RFT-I

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein. Note: Membrane-bound form in trans cisternae of Golgi.
Tissue specificity	Brain.
Miscellaneous	There are two genes (Fut1 and Fut2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.
Sequence similarities	Belongs to the glycosyltransferase 11 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Galactoside 2-alpha-L-fucosyltransferase 1		PRO_0000149101
Regions
	Topological domain	1 – 12	12	Cytoplasmic Potential
	Transmembrane	13 – 29	17	Signal-anchor for type II membrane protein Potential
	Topological domain	30 – 373	344	Lumenal Potential
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	327	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q10979-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0A47A1786231525C	FASTA	373	42,099
	10 20 30 40 50 60 MWPPSRRQLC LAFLLVCALS AFSFLLHLHQ DLFRNGLALS LPCLERQPVP APVAIVCLPV 70 80 90 100 110 120 TSPASNASSC AGRPAAPSGI WTIHPDGRFG NQMGQYATLL ALAQLNGRRA FILPAMHAAL 130 140 150 160 170 180 APVFRITLPV LAPEVNRRTS WKQLLLHDWM SEEYSRLEDP FLKFTGFPCS WTFFHHVREQ 190 200 210 220 230 240 IRREFTLHDH LREEAQRLLG KLRLGRTGAR PRTFVGVHVR RGDYLQVMPQ RWKGVVGDRA 250 260 270 280 290 300 YLQQAMDWFR ARHEAPIFVV TSNGMKWCWE NIDASRGDVV FAGNGLESSP AKDFALLTQC 310 320 330 340 350 360 NHTVMTIGTF GFWAAYLAGG DTVYLANFTL PDSEFLKIFK PEAAFLPEWV GINADLSPVR 370 TLSGSWRPWR FLG

References

[1]	"Molecular cloning and expression of two types of rabbit beta-galactoside alpha 1,2-fucosyltransferase." Hitoshi S., Kusunoki S., Kanazawa I., Tsuji S. J. Biol. Chem. 270:8844-8850(1995) [PubMed: 7721792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X80226 mRNA. Translation: CAA56513.1.
PIR	A56392.
RefSeq	NP_001075872.1.
UniGene	Ocu.2106
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Genome annotation databases
Ensembl	ENSOCUT00000017162; ENSOCUP00000014751; ENSOCUG00000017168; Oryctolagus cuniculus. [Genome view]
GeneID	100009291.
Organism-specific databases
CTD	100009291.
Phylogenomic databases
HOVERGEN	Q10979.
Enzyme and pathway databases
BRENDA	2.4.1.69. 255.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT1_RABIT

Accession

Primary (citable) accession number: Q10979

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	October 13, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)