ID   GLND_MYCTU              Reviewed;         808 AA.
AC   Q10961;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 57.
DE   RecName: Full=[Protein-PII] uridylyltransferase;
DE            Short=PII uridylyl-transferase;
DE            EC=2.7.7.59;
DE   AltName: Full=Uridylyl-removing enzyme;
DE   AltName: Full=UTase;
GN   Name=glnD; OrderedLocusNames=Rv2918c, MT2986; ORFNames=MTCY338.07c;
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   MEDLINE=98295987; PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA   Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA   Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA   Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA   Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA   Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA   Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the
RT   complete genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   MEDLINE=22206494; PubMed=12218036;
RX   DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA   Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA   Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA   Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA   Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Modifies, by uridylylation or deuridylylation the PII
CC       (glnB) regulatory protein (By similarity).
CC   -!- CATALYTIC ACTIVITY: UTP + [protein-PII] = diphosphate + uridylyl-
CC       [protein-PII].
CC   -!- SIMILARITY: Belongs to the glnD family.
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DR   EMBL; BX842581; CAA98971.1; -; Genomic_DNA.
DR   EMBL; AE000516; AAK47312.1; -; Genomic_DNA.
DR   PIR; F70747; F70747.
DR   RefSeq; NP_217434.1; -.
DR   RefSeq; NP_337498.1; -.
DR   GeneID; 888621; -.
DR   GeneID; 925289; -.
DR   GenomeReviews; AE000516_GR; MT2986.
DR   GenomeReviews; AL123456_GR; Rv2918c.
DR   KEGG; mtc:MT2986; -.
DR   KEGG; mtu:Rv2918c; -.
DR   TIGR; MT2986; -.
DR   TubercuList; Rv2918c; -.
DR   HOGENOM; Q10961; -.
DR   OMA; Q10961; RTIAYHA.
DR   BRENDA; 2.7.7.59; 809.
DR   GO; GO:0008773; F:[protein-PII] uridylyltransferase activity; IEA:HAMAP.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_00277; -; 1.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR010043; GlnD_Uridyltrans.
DR   InterPro; IPR003607; Met-dep_phosphohydro_HD.
DR   InterPro; IPR006674; Met-dep_phosphohydro_HD_sub.
DR   InterPro; IPR013546; PII_UdlTrfase/GS_AdlTrfase.
DR   PANTHER; PTHR13734:SF1; GlnD_Uridyltrans; 1.
DR   Pfam; PF01842; ACT; 2.
DR   Pfam; PF08335; GlnD_UR_UTase; 1.
DR   Pfam; PF01966; HD; 1.
DR   PIRSF; PIRSF006288; PII_uridyltransf; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR01693; UTase_glnD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Nucleotidyltransferase; Transferase.
FT   CHAIN         1    808       [Protein-PII] uridylyltransferase.
FT                                /FTId=PRO_0000192745.
SQ   SEQUENCE   808 AA;  86438 MW;  9B1F14D01C29F0B0 CRC64;
     MEAESPCAAS DLAVARRELL SGNHRELDPV GLRQTWLDLH ESWLIDKADE IGIADASGFA
     IVGVGGLGRR ELLPYSDLDV LLLHDGKPAD ILRPVADRLW YPLWDANIRL DHSVRTVSEA
     LTIANSDLMA ALGMLEARHI AGDQQLSFAL IDGVRRQWRN GIRSRMGELV EMTYARWRRC
     GRIAQRAEPD LKLGRGGLRD VQLLDALALA QLIDRHGIGH TDLPAGSLDG AYRTLLDVRT
     ELHRVSGRGR DHLLAQFADE ISAALGFGDR FDLARTLSSA GRTIGYHAEA GLRTAANALP
     RRGISALVRR PKRRPLDEGV VEYAGEIVLA RDAEPEHDPG LVLRVAAASA DTGLPIGAAT
     LSRLAASVPD LPTPWPQEAL DDLLVVLSAG PTTVATIEAL DRTGLWGRLL PEWEPIRDLP
     PRDVAHKWTV DRHVVETAVH AAPLATRVAR PDLLALGALL HDIGKGRGTD HSVLGAELVI
     PVCTRLGLSP PDVRTLSKLV RHHLLLPITA TRRDLNDPKT IEAVSEALGG DPQLLEVLHA
     LSEADSKATG PGVWSDWKAS LVDDLVRRCR MVMAGESLPQ AEPTAPHYLS LAADHGVHVE
     ISPRDGERID AVIVAPDERG LVSKAAAVLA LNSLRVHSAS VNVHQGVAIT EFVVSPLFGS
     PPAAELVRQQ FVGALNGDVD VLGMLQKRDS DAASLVSARA GDVQAGVPVT RTAAPPRILW
     LDTAAPAKLI LEVRAMDRAG LLALLAGALE GAGAGIVWAK VNTFGSTAAD VFCVTVPAEL
     DARAAVEQHL LEVLGASVDV VVDEPVGD
//