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Protein

Armadillo repeat-containing protein wrm-1

Gene

wrm-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1-dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome positioning and can activation transcription in yeast. Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells (PubMed:17476329).10 Publications

GO - Molecular functioni

  • nuclear hormone receptor binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: WormBase
  • transcription coactivator activity Source: WormBase
  • transcription factor binding Source: WormBase

GO - Biological processi

  • activation of MAPK activity Source: WormBase
  • asymmetric protein localization involved in cell fate determination Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • embryonic body morphogenesis Source: WormBase
  • endodermal cell fate specification Source: WormBase
  • endodermal digestive tract morphogenesis Source: UniProtKB
  • endoderm development Source: UniProtKB
  • establishment of mitotic spindle orientation Source: UniProtKB
  • left/right axis specification Source: UniProtKB
  • negative regulation of cell division Source: UniProtKB
  • negative regulation of DNA binding transcription factor activity Source: UniProtKB
  • pharyngeal muscle development Source: UniProtKB
  • polarity specification of proximal/distal axis Source: WormBase
  • positive regulation of asymmetric protein localization involved in cell fate determination Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB
  • positive regulation of endodermal cell differentiation Source: UniProtKB
  • positive regulation of protein homooligomerization Source: WormBase
  • positive regulation of protein kinase activity Source: WormBase
  • positive regulation of protein localization to nucleus Source: WormBase
  • positive regulation of protein phosphorylation Source: WormBase
  • positive regulation of protein serine/threonine kinase activity Source: WormBase
  • positive regulation of transcription by RNA polymerase II Source: WormBase
  • protein phosphorylation Source: GOC
  • regulation of embryonic development Source: UniProtKB
  • regulation of endodermal cell differentiation Source: UniProtKB
  • regulation of mesodermal cell fate specification Source: UniProtKB
  • regulation of protein localization Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • Wnt signaling pathway Source: WormBase
  • Wnt signaling pathway involved in digestive tract morphogenesis Source: UniProtKB
  • Wnt signaling pathway involved in dorsal/ventral axis specification Source: UniProtKB

Keywordsi

Molecular functionActivator, Developmental protein
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

SignaLinkiQ10953

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein wrm-1
Alternative name(s):
Worm armadillo protein 1
Gene namesi
Name:wrm-1Imported
ORF Names:B0336.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0336.1 ; CE26743 ; WBGene00006943 ; wrm-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Worms exhibit premature cell cleavage during embryogenesis, symmetrical cell division during gonadogenesis and undifferentiated intestines. Embryos show a defect in centrosome positioning that delays ABar spindle alignment and appear to lack endoderm.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003427011 – 796Armadillo repeat-containing protein wrm-1Add BLAST796

Proteomic databases

EPDiQ10953
PaxDbiQ10953
PeptideAtlasiQ10953
PRIDEiQ10953

Expressioni

Developmental stagei

Expressed in the developing cells of the embryo including hypodermal cells, neuroblasts, and mesodermal cells (PubMed:15572126). Expressed in seam cells in hermaphrodites at the L2 stage of larval development (PubMed:25569233).1 Publication

Gene expression databases

BgeeiWBGene00006943
ExpressionAtlasiQ10953 baseline and differential

Interactioni

Subunit structurei

Interacts (independently of ARM repeat) with nhr-25. Interacts (via N-terminus) with lit-1; activates lit-1 kinase activity and the wrm-1/lit-1 dimer phosphorylates pop-1 which promotes pop-1 interaction with par-5 and translocation of pop-1 from the nucleus to the cytoplasm.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • nuclear hormone receptor binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • transcription factor binding Source: WormBase

Protein-protein interaction databases

BioGridi41028, 4 interactors
IntActiQ10953, 22 interactors
MINTiQ10953
STRINGi6239.B0336.1

Structurei

3D structure databases

ProteinModelPortaliQ10953
SMRiQ10953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati462 – 504ARMSequence analysisAdd BLAST43

Phylogenomic databases

eggNOGiENOG410K88M Eukaryota
ENOG4110KM8 LUCA
HOGENOMiHOG000154864
InParanoidiQ10953
KOiK02105
OMAiSIYENCL
OrthoDBiEOG091G05X9

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
SMARTiView protein in SMART
SM00185 ARM, 3 hits
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Q10953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVDCAETFS QPCTPLNFNP MTPSTSRVST PVRPSSTMSA RQYSGSPFKA
60 70 80 90 100
QPQNMEPSNS RVQELREAAV GKRSYTNAWM QGTYAPPQMA GQQQRFSRPP
110 120 130 140 150
SVIGSTMSHM TNMSEMTAYS YGGLSMLSVN TEMGEFNNFV NQAPYQRALT
160 170 180 190 200
RVSQVSENQD PTNRQYPMTA PEIIENLEST ELINQAAAIR ALEPIVKAGG
210 220 230 240 250
MLQTWGPKGA EPIIRALFQV LIPRPVENEN VIRKAFEILH HSILLSNKEI
260 270 280 290 300
RRIDRMFFRL NAALMDPNGP PVFNVPKPYS IYEIVMTRAI QLDTKFESSA
310 320 330 340 350
MVLLVHLCCK PHFMKIFFGE DETQQSPAHR RLHKIVIEFA IGNLRRPETK
360 370 380 390 400
SKNKGLCVSI IKNLSNKNAT IKDMSERLGV VSLFHQIMQN EVIHEDLLWS
410 420 430 440 450
TMQALTVFCG DVKNGTHFVQ MGGAQVLCGL LSHGSTRLLH ELLKCLRRVS
460 470 480 490 500
DLPAIQEQDM KESIHCIVQL IGCSDVTIVE LATGTLRNIG LHNKMNKAFM
510 520 530 540 550
VQDGVTSHAI AVLRTSEQFT YQPHANIDLY RKQILSIYEN CLSVLNNVTS
560 570 580 590 600
MAPQDIKESA VSACRMISEN ADSAYVLLHY FNVGNRKCRK LAVTVMKRVI
610 620 630 640 650
ETVPAFADPF VDLLGTTNEP LPILLLQRAF QSLDEWRKTS VEMMNCDGRS
660 670 680 690 700
AEQRRELDDR RKDHEDIVKR SVGLLTNLCS QANPRFFHSL KLVLTNGTLN
710 720 730 740 750
PFQWLTHEMS DGILQEWLAF ILSICSRDES LQTFMMYRFL EQAKMTEAFF
760 770 780 790
AELKARRQNS NIQTMLSKII DLGRHQQRIV SQQHQQHQMQ HHRQLM
Length:796
Mass (Da):90,349
Last modified:June 1, 2001 - v2
Checksum:iB517C7A804A7DEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013951 mRNA Translation: AAC47748.1
FO080138 Genomic DNA Translation: CCD61515.1
PIRiT03746
RefSeqiNP_498236.1, NM_065835.6
UniGeneiCel.16964

Genome annotation databases

EnsemblMetazoaiB0336.1a.1; B0336.1a.1; WBGene00006943
B0336.1a.2; B0336.1a.2; WBGene00006943
GeneIDi175802
KEGGicel:CELE_B0336.1
UCSCiB0336.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiWRM1_CAEEL
AccessioniPrimary (citable) accession number: Q10953
Secondary accession number(s): O16145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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