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Protein

Armadillo repeat-containing protein wrm-1

Gene

wrm-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1-dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome positioning and can activation transcription in yeast. Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells (PubMed:17476329).10 Publications

GO - Molecular functioni

  • nuclear hormone receptor binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • transcription coactivator activity Source: WormBase
  • transcription factor binding Source: WormBase

GO - Biological processi

  • asymmetric protein localization involved in cell fate determination Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • embryonic body morphogenesis Source: WormBase
  • endodermal cell fate specification Source: WormBase
  • endoderm development Source: UniProtKB
  • establishment of mitotic spindle orientation Source: UniProtKB
  • left/right axis specification Source: UniProtKB
  • negative regulation of cell division Source: UniProtKB
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • polarity specification of proximal/distal axis Source: WormBase
  • positive regulation of asymmetric protein localization involved in cell fate determination Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB
  • positive regulation of protein kinase activity Source: WormBase
  • positive regulation of protein phosphorylation Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • protein phosphorylation Source: GOC
  • regulation of embryonic development Source: UniProtKB
  • regulation of protein localization Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • Wnt signaling pathway Source: WormBase
  • Wnt signaling pathway involved in digestive tract morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

SignaLinkiQ10953.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein wrm-1
Alternative name(s):
Worm armadillo protein 1
Gene namesi
Name:wrm-1Imported
ORF Names:B0336.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0336.1; CE26743; WBGene00006943; wrm-1.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: WormBase
  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • serine/threonine protein kinase complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Worms exhibit premature cell cleavage during embryogenesis, symmetrical cell division during gonadogenesis and undifferentiated intestines. Embryos show a defect in centrosome positioning that delays ABar spindle alignment and appear to lack endoderm.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003427011 – 796Armadillo repeat-containing protein wrm-1Add BLAST796

Proteomic databases

EPDiQ10953.
PaxDbiQ10953.
PeptideAtlasiQ10953.

Expressioni

Developmental stagei

Expressed in the developing cells of the embryo including hypodermal cells, neuroblasts, and mesodermal cells (PubMed:15572126). Expressed in seam cells in hermaphrodites at the L2 stage of larval development (PubMed:25569233).1 Publication

Gene expression databases

BgeeiWBGene00006943.
ExpressionAtlasiQ10953. differential.

Interactioni

Subunit structurei

Interacts (independently of ARM repeat) with nhr-25. Interacts (via N-terminus) with lit-1; activates lit-1 kinase activity and the wrm-1/lit-1 dimer phosphorylates pop-1 which promotes pop-1 interaction with par-5 and translocation of pop-1 from the nucleus to the cytoplasm.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
lit-1Q9U9Y88EBI-2530558,EBI-318513
nhr-25Q193453EBI-2530558,EBI-3871243

GO - Molecular functioni

  • nuclear hormone receptor binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • transcription factor binding Source: WormBase

Protein-protein interaction databases

BioGridi41028. 4 interactors.
IntActiQ10953. 22 interactors.
MINTiMINT-3384368.
STRINGi6239.B0336.1.

Structurei

3D structure databases

ProteinModelPortaliQ10953.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati462 – 504ARMSequence analysisAdd BLAST43

Sequence similaritiesi

Contains 1 ARM repeat.Sequence analysis

Phylogenomic databases

eggNOGiENOG410K88M. Eukaryota.
ENOG4110KM8. LUCA.
HOGENOMiHOG000154864.
InParanoidiQ10953.
KOiK02105.
OMAiSIYENCL.
OrthoDBiEOG091G05X9.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q10953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVDCAETFS QPCTPLNFNP MTPSTSRVST PVRPSSTMSA RQYSGSPFKA
60 70 80 90 100
QPQNMEPSNS RVQELREAAV GKRSYTNAWM QGTYAPPQMA GQQQRFSRPP
110 120 130 140 150
SVIGSTMSHM TNMSEMTAYS YGGLSMLSVN TEMGEFNNFV NQAPYQRALT
160 170 180 190 200
RVSQVSENQD PTNRQYPMTA PEIIENLEST ELINQAAAIR ALEPIVKAGG
210 220 230 240 250
MLQTWGPKGA EPIIRALFQV LIPRPVENEN VIRKAFEILH HSILLSNKEI
260 270 280 290 300
RRIDRMFFRL NAALMDPNGP PVFNVPKPYS IYEIVMTRAI QLDTKFESSA
310 320 330 340 350
MVLLVHLCCK PHFMKIFFGE DETQQSPAHR RLHKIVIEFA IGNLRRPETK
360 370 380 390 400
SKNKGLCVSI IKNLSNKNAT IKDMSERLGV VSLFHQIMQN EVIHEDLLWS
410 420 430 440 450
TMQALTVFCG DVKNGTHFVQ MGGAQVLCGL LSHGSTRLLH ELLKCLRRVS
460 470 480 490 500
DLPAIQEQDM KESIHCIVQL IGCSDVTIVE LATGTLRNIG LHNKMNKAFM
510 520 530 540 550
VQDGVTSHAI AVLRTSEQFT YQPHANIDLY RKQILSIYEN CLSVLNNVTS
560 570 580 590 600
MAPQDIKESA VSACRMISEN ADSAYVLLHY FNVGNRKCRK LAVTVMKRVI
610 620 630 640 650
ETVPAFADPF VDLLGTTNEP LPILLLQRAF QSLDEWRKTS VEMMNCDGRS
660 670 680 690 700
AEQRRELDDR RKDHEDIVKR SVGLLTNLCS QANPRFFHSL KLVLTNGTLN
710 720 730 740 750
PFQWLTHEMS DGILQEWLAF ILSICSRDES LQTFMMYRFL EQAKMTEAFF
760 770 780 790
AELKARRQNS NIQTMLSKII DLGRHQQRIV SQQHQQHQMQ HHRQLM
Length:796
Mass (Da):90,349
Last modified:June 1, 2001 - v2
Checksum:iB517C7A804A7DEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013951 mRNA. Translation: AAC47748.1.
FO080138 Genomic DNA. Translation: CCD61515.1.
PIRiT03746.
RefSeqiNP_498236.1. NM_065835.6.
UniGeneiCel.16964.

Genome annotation databases

EnsemblMetazoaiB0336.1a; B0336.1a; WBGene00006943.
GeneIDi175802.
KEGGicel:CELE_B0336.1.
UCSCiB0336.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013951 mRNA. Translation: AAC47748.1.
FO080138 Genomic DNA. Translation: CCD61515.1.
PIRiT03746.
RefSeqiNP_498236.1. NM_065835.6.
UniGeneiCel.16964.

3D structure databases

ProteinModelPortaliQ10953.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41028. 4 interactors.
IntActiQ10953. 22 interactors.
MINTiMINT-3384368.
STRINGi6239.B0336.1.

Proteomic databases

EPDiQ10953.
PaxDbiQ10953.
PeptideAtlasiQ10953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0336.1a; B0336.1a; WBGene00006943.
GeneIDi175802.
KEGGicel:CELE_B0336.1.
UCSCiB0336.1. c. elegans.

Organism-specific databases

CTDi175802.
WormBaseiB0336.1; CE26743; WBGene00006943; wrm-1.

Phylogenomic databases

eggNOGiENOG410K88M. Eukaryota.
ENOG4110KM8. LUCA.
HOGENOMiHOG000154864.
InParanoidiQ10953.
KOiK02105.
OMAiSIYENCL.
OrthoDBiEOG091G05X9.

Enzyme and pathway databases

SignaLinkiQ10953.

Miscellaneous databases

PROiQ10953.

Gene expression databases

BgeeiWBGene00006943.
ExpressionAtlasiQ10953. differential.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiWRM1_CAEEL
AccessioniPrimary (citable) accession number: Q10953
Secondary accession number(s): O16145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.