ID   PISD_CAEEL              Reviewed;         377 AA.
AC   Q10949; Q6AHR5;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 2.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Phosphatidylserine decarboxylase proenzyme;
DE            EC=4.1.1.65;
DE   Contains:
DE     RecName: Full=Phosphatidylserine decarboxylase alpha chain;
DE   Contains:
DE     RecName: Full=Phosphatidylserine decarboxylase beta chain;
GN   Name=psd-1; ORFNames=B0361.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
RP   SPLICING.
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: Phosphatidyl-L-serine =
CC       phosphatidylethanolamine + CO(2).
CC   -!- COFACTOR: Pyruvoyl group (By similarity).
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC       biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol:
CC       step 2/2.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b;
CC         IsoId=Q10949-1; Sequence=Displayed;
CC         Note=No experimental confirmation available;
CC       Name=a;
CC         IsoId=Q10949-2; Sequence=VSP_013776, VSP_013777;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the phosphatidylserine decarboxylase
CC       family.
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DR   EMBL; U00031; AAK18866.2; -; Genomic_DNA.
DR   EMBL; U00031; AAT92090.1; -; Genomic_DNA.
DR   PIR; A88504; A88504.
DR   RefSeq; NP_001021128.1; -.
DR   UniGene; Cel.10944; -.
DR   PRIDE; Q10949; -.
DR   Ensembl; B0361.5; Caenorhabditis elegans.
DR   GeneID; 176027; -.
DR   WormBase; WBGene00015159; psd-1.
DR   WormPep; B0361.5a; CE37696.
DR   WormPep; B0361.5b; CE37076.
DR   OMA; Q10949; CLNERVV.
DR   BRENDA; 4.1.1.65; 672.
DR   NextBio; 890802; -.
DR   ArrayExpress; Q10949; -.
DR   GO; GO:0004609; F:phosphatidylserine decarboxylase activity; IEA:EC.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0040010; P:positive regulation of growth rate; IMP:WormBase.
DR   InterPro; IPR003817; PS_Dcarbxylase.
DR   InterPro; IPR005221; PS_decarb.
DR   PANTHER; PTHR10067; PS_decarb; 1.
DR   Pfam; PF02666; PS_Dcarbxylase; 1.
DR   TIGRFAMs; TIGR00163; PS_decarb; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Decarboxylase; Lyase;
KW   Phospholipid biosynthesis; Pyruvate; Zymogen.
FT   CHAIN         1    343       Phosphatidylserine decarboxylase beta
FT                                chain (By similarity).
FT                                /FTId=PRO_0000029841.
FT   CHAIN       344    377       Phosphatidylserine decarboxylase alpha
FT                                chain (By similarity).
FT                                /FTId=PRO_0000029842.
FT   SITE        343    344       Cleavage (non-hydrolytic) (By
FT                                similarity).
FT   MOD_RES     344    344       Pyruvic acid (Ser) (By similarity).
FT   VAR_SEQ       2     30       Missing (in isoform a).
FT                                /FTId=VSP_013776.
FT   VAR_SEQ      31     57       VRELTNQSKNVYATKEVIIGASQKKKR -> LDIYSGGFLH
FT                                PDSLMALNPFLIFVAFW (in isoform a).
FT                                /FTId=VSP_013777.
SQ   SEQUENCE   377 AA;  42487 MW;  DDBD39AAC26C9D5B CRC64;
     MMPLFNVLRS ARMLPAVSKK VVSPPMMLRS VRELTNQSKN VYATKEVIIG ASQKKKRSWV
     KWLSVSTLII GGASYVGYLF TPDWREIVDS KHYYSNWKIR VYLSLPFNTA SRVIGGLANQ
     EIPVWLREHL LGGFARMYDC RMDDCVDPDF KNYPSFAAFF NRKLKESTRP ISASPLVSPA
     DGTVLHFGKV EDNKIEYVKG HDYDVDKFLG DVDLPQKDEL DLYQVVIYLA PGDYHAFHSP
     ARWVANQCRH VPGLLLSVRP TLLSHVPHLF CLNERVVLNG SWRHGFFSMS AVAATNVGDI
     VVDAEPSLRT NIVRRKTQKI MNTETEIHAP YVSGERVGEF RLGSTIVLVF QAPPTIKFAI
     KAGDPLRYGQ SLVADGV
//