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Q10949 (PISD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd-1
ORF Names:B0361.5
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.

Cofactor

Pyruvoyl group By similarity.

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Coding sequence diversityAlternative splicing
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of growth rate

Inferred from mutant phenotype. Source: WormBase

   Molecular functionphosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform b (identifier: Q10949-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform a (identifier: Q10949-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-30: Missing.
     31-57: VRELTNQSKNVYATKEVIIGASQKKKR → LDIYSGGFLHPDSLMALNPFLIFVAFW
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000029841
Chain344 – 37734Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000029842

Sites

Site343 – 3442Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue3441Pyruvic acid (Ser) By similarity

Natural variations

Alternative sequence2 – 3029Missing in isoform a.
VSP_013776
Alternative sequence31 – 5727VRELT…QKKKR → LDIYSGGFLHPDSLMALNPF LIFVAFW in isoform a.
VSP_013777

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified May 24, 2005. Version 2.
Checksum: DDBD39AAC26C9D5B

FASTA37742,487
        10         20         30         40         50         60 
MMPLFNVLRS ARMLPAVSKK VVSPPMMLRS VRELTNQSKN VYATKEVIIG ASQKKKRSWV 

        70         80         90        100        110        120 
KWLSVSTLII GGASYVGYLF TPDWREIVDS KHYYSNWKIR VYLSLPFNTA SRVIGGLANQ 

       130        140        150        160        170        180 
EIPVWLREHL LGGFARMYDC RMDDCVDPDF KNYPSFAAFF NRKLKESTRP ISASPLVSPA 

       190        200        210        220        230        240 
DGTVLHFGKV EDNKIEYVKG HDYDVDKFLG DVDLPQKDEL DLYQVVIYLA PGDYHAFHSP 

       250        260        270        280        290        300 
ARWVANQCRH VPGLLLSVRP TLLSHVPHLF CLNERVVLNG SWRHGFFSMS AVAATNVGDI 

       310        320        330        340        350        360 
VVDAEPSLRT NIVRRKTQKI MNTETEIHAP YVSGERVGEF RLGSTIVLVF QAPPTIKFAI 

       370 
KAGDPLRYGQ SLVADGV

« Hide

Isoform a [UniParc].

Checksum: 62C3FE6DB78ADE35
Show »

FASTA34839,243

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO080185 Genomic DNA. Translation: CCD61819.1.
FO080185 Genomic DNA. Translation: CCD61820.1.
PIRA88504.
RefSeqNP_001021127.1. NM_001025956.2.
NP_001021128.1. NM_001025957.2.
UniGeneCel.10944.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ10949.

Proteomic databases

PRIDEQ10949.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0361.5b.1; B0361.5b.1; B0361.5.
B0361.5b.2; B0361.5b.2; B0361.5.
GeneID176027.
KEGGcel:B0361.5.
UCSCB0361.5b. c. elegans.

Organism-specific databases

CTD176027.
WormBaseB0361.5a; CE37696; WBGene00015159; psd-1.
B0361.5b; CE37076; WBGene00015159; psd-1.

Phylogenomic databases

eggNOGmeNOG06655.
GeneTreeEMGT00050000018014.
HOGENOMHBG395511.
InParanoidQ10949.
OMASELAFFR.
PhylomeDBQ10949.

Gene expression databases

ArrayExpressQ10949.

Family and domain databases

InterProIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
KOK01613.
PANTHERPTHR10067. PS_decarb. 1 hit.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00163. PS_decarb. 1 hit.
ProtoNetSearch...

Other

NextBio890802.

Entry information

Entry namePISD_CAEEL
AccessionPrimary (citable) accession number: Q10949
Secondary accession number(s): Q6AHR5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: December 14, 2011
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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