Reviewed, UniProtKB/Swiss-Prot Q10949 (PISD_CAEEL)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd-1
ORF Names:	B0361.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Coding sequence diversity	Alternative splicing
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase
Molecular function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform b (identifier: Q10949-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform a (identifier: Q10949-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-30: Missing.
     31-57: VRELTNQSKNVYATKEVIIGASQKKKR → LDIYSGGFLHPDSLMALNPFLIFVAFW

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029841
	Chain	344 – 377	34	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029842
Sites
	Site	343 – 344	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	344	1	Pyruvic acid (Ser) By similarity
Natural variations
	Alternative sequence	2 – 30	29	Missing in isoform a.		VSP_013776
	Alternative sequence	31 – 57	27	VRELT…QKKKR → LDIYSGGFLHPDSLMALNPF LIFVAFW in isoform a.		VSP_013777

Sequences

	Sequence		Length	Mass (Da)
	Isoform b [UniParc]. Last modified May 24, 2005. Version 2. Checksum: DDBD39AAC26C9D5B	FASTA	377	42,487
	10 20 30 40 50 60 MMPLFNVLRS ARMLPAVSKK VVSPPMMLRS VRELTNQSKN VYATKEVIIG ASQKKKRSWV 70 80 90 100 110 120 KWLSVSTLII GGASYVGYLF TPDWREIVDS KHYYSNWKIR VYLSLPFNTA SRVIGGLANQ 130 140 150 160 170 180 EIPVWLREHL LGGFARMYDC RMDDCVDPDF KNYPSFAAFF NRKLKESTRP ISASPLVSPA 190 200 210 220 230 240 DGTVLHFGKV EDNKIEYVKG HDYDVDKFLG DVDLPQKDEL DLYQVVIYLA PGDYHAFHSP 250 260 270 280 290 300 ARWVANQCRH VPGLLLSVRP TLLSHVPHLF CLNERVVLNG SWRHGFFSMS AVAATNVGDI 310 320 330 340 350 360 VVDAEPSLRT NIVRRKTQKI MNTETEIHAP YVSGERVGEF RLGSTIVLVF QAPPTIKFAI 370 KAGDPLRYGQ SLVADGV
	Isoform a. Checksum: 62C3FE6DB78ADE35	FASTA	348	39,243
	10 20 30 40 50 60 MLDIYSGGFL HPDSLMALNP FLIFVAFWSW VKWLSVSTLI IGGASYVGYL FTPDWREIVD 70 80 90 100 110 120 SKHYYSNWKI RVYLSLPFNT ASRVIGGLAN QEIPVWLREH LLGGFARMYD CRMDDCVDPD 130 140 150 160 170 180 FKNYPSFAAF FNRKLKESTR PISASPLVSP ADGTVLHFGK VEDNKIEYVK GHDYDVDKFL 190 200 210 220 230 240 GDVDLPQKDE LDLYQVVIYL APGDYHAFHS PARWVANQCR HVPGLLLSVR PTLLSHVPHL 250 260 270 280 290 300 FCLNERVVLN GSWRHGFFSM SAVAATNVGD IVVDAEPSLR TNIVRRKTQK IMNTETEIHA 310 320 330 340 PYVSGERVGE FRLGSTIVLV FQAPPTIKFA IKAGDPLRYG QSLVADGV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00031 Genomic DNA. Translation: AAK18866.2. U00031 Genomic DNA. Translation: AAT92090.1.
PIR	A88504.
RefSeq	NP_001021127.1. NP_001021128.1.
UniGene	Cel.10944
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q10949.
Proteomic databases
PRIDE	Q10949.
Genome annotation databases
Ensembl	B0361.5b; B0361.5b; B0361.5; Caenorhabditis elegans. [Genome view]
GeneID	176027.
KEGG	cel:B0361.5.
UCSC	B0361.5b. c. elegans.
Organism-specific databases
CTD	176027.
WormBase	WBGene00015159. psd-1.
WormPep	B0361.5a. CE37696. [WorfDB] B0361.5b. CE37076. [WorfDB]
Phylogenomic databases
eggNOG	meNOG06655.
HOGENOM	HBG395511.
InParanoid	Q10949.
OMA	RISENEC.
PhylomeDB	Q10949.
Enzyme and pathway databases
BRENDA	4.1.1.65. 672.
Gene expression databases
ArrayExpress	Q10949.
Family and domain databases
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
PANTHER	PTHR10067. PS_decarb. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	890802.

Entry information

Entry name

PISD_CAEEL

Accession

Primary (citable) accession number: Q10949
Secondary accession number(s): Q6AHR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 24, 2005
Last modified:	February 9, 2010
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project