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Q10944

- PHO5_CAEEL

UniProt

Q10944 - PHO5_CAEEL

Protein

Putative acid phosphatase 5

Gene

pho-5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (30 May 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401NucleophileBy similarity
    Active sitei279 – 2791Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative acid phosphatase 5 (EC:3.1.3.2)
    Gene namesi
    Name:pho-5
    ORF Names:B0361.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiB0361.7; CE32100; WBGene00015161; pho-5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1313Sequence AnalysisAdd
    BLAST
    Chaini14 – 422409Putative acid phosphatase 5PRO_0000023968Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 363By similarity
    Disulfide bondi205 ↔ 302By similarity
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)1 Publication
    Disulfide bondi338 ↔ 342By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ10944.
    PRIDEiQ10944.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.B0361.7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10944.
    SMRiQ10944. Positions 31-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG85977.
    GeneTreeiENSGT00530000062956.
    HOGENOMiHOG000020614.
    InParanoidiQ10944.
    KOiK14410.
    OMAiTLEYVHT.
    OrthoDBiEOG7GXPBJ.
    PhylomeDBiQ10944.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10944-1 [UniParc]FASTAAdd to Basket

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    MLLLLVLLIG ASGINAVVYK EVPIQANTDT LEYVHTVWRH GDRTPAELLF    50
    PDDITKWPEG LGELTEQGAA QQYRLGQWLK RRYGSWLGEK FNRNAIYIRS 100
    SDYNRTLMSA QANMAGLFPP KYPIAGGLMW QPIPVHTISK PTDKELYEEA 150
    SCPTAEIEMN AQWKSTKANG IRKKFARELS FFSQKLNLPN MELKATWRIF 200
    DNLFCEKQNN ITWPSWMNSS IFERVDQLYN EVSQLEFHTD TLRRLRGGTL 250
    LEEIFHRFSD KASGSLGKEA KFYAYSAHDS TIAALLATLG VFYDIYPKYA 300
    TCLLIEMHKL ANETRLIRVF HKNETDIDRL IEYSIPGCDD PCTLQKLGDD 350
    LKKYFPEDWE AECGLKTSFQ FIYLVIISIL VISTVCSCTM LFVEKQKRKI 400
    LRFPVDGLRD DTAPMLGGDD SD 422
    Length:422
    Mass (Da):48,409
    Last modified:May 30, 2003 - v3
    Checksum:i3E29FACB4FAE0CAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080185 Genomic DNA. Translation: CCD61822.1.
    RefSeqiNP_498604.2. NM_066203.7.
    UniGeneiCel.10942.

    Genome annotation databases

    EnsemblMetazoaiB0361.7; B0361.7; WBGene00015161.
    GeneIDi176030.
    KEGGicel:CELE_B0361.7.
    UCSCiB0361.7. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080185 Genomic DNA. Translation: CCD61822.1 .
    RefSeqi NP_498604.2. NM_066203.7.
    UniGenei Cel.10942.

    3D structure databases

    ProteinModelPortali Q10944.
    SMRi Q10944. Positions 31-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0361.7.

    Proteomic databases

    PaxDbi Q10944.
    PRIDEi Q10944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0361.7 ; B0361.7 ; WBGene00015161 .
    GeneIDi 176030.
    KEGGi cel:CELE_B0361.7.
    UCSCi B0361.7. c. elegans.

    Organism-specific databases

    CTDi 176030.
    WormBasei B0361.7 ; CE32100 ; WBGene00015161 ; pho-5.

    Phylogenomic databases

    eggNOGi NOG85977.
    GeneTreei ENSGT00530000062956.
    HOGENOMi HOG000020614.
    InParanoidi Q10944.
    KOi K14410.
    OMAi TLEYVHT.
    OrthoDBi EOG7GXPBJ.
    PhylomeDBi Q10944.

    Miscellaneous databases

    NextBioi 890816.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
      Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
      Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPHO5_CAEEL
    AccessioniPrimary (citable) accession number: Q10944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3