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Q10944 (PHO5_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative acid phosphatase 5

EC=3.1.3.2
Gene names
Name:pho-5
ORF Names:B0361.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1313 Potential
Chain14 – 422409Putative acid phosphatase 5
PRO_0000023968

Sites

Active site401Nucleophile By similarity
Active site2791Proton donor By similarity

Amino acid modifications

Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Ref.2
Disulfide bond152 ↔ 363 By similarity
Disulfide bond205 ↔ 302 By similarity
Disulfide bond338 ↔ 342 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q10944 [UniParc].

Last modified May 30, 2003. Version 3.
Checksum: 3E29FACB4FAE0CAC

FASTA42248,409
        10         20         30         40         50         60 
MLLLLVLLIG ASGINAVVYK EVPIQANTDT LEYVHTVWRH GDRTPAELLF PDDITKWPEG 

        70         80         90        100        110        120 
LGELTEQGAA QQYRLGQWLK RRYGSWLGEK FNRNAIYIRS SDYNRTLMSA QANMAGLFPP 

       130        140        150        160        170        180 
KYPIAGGLMW QPIPVHTISK PTDKELYEEA SCPTAEIEMN AQWKSTKANG IRKKFARELS 

       190        200        210        220        230        240 
FFSQKLNLPN MELKATWRIF DNLFCEKQNN ITWPSWMNSS IFERVDQLYN EVSQLEFHTD 

       250        260        270        280        290        300 
TLRRLRGGTL LEEIFHRFSD KASGSLGKEA KFYAYSAHDS TIAALLATLG VFYDIYPKYA 

       310        320        330        340        350        360 
TCLLIEMHKL ANETRLIRVF HKNETDIDRL IEYSIPGCDD PCTLQKLGDD LKKYFPEDWE 

       370        380        390        400        410        420 
AECGLKTSFQ FIYLVIISIL VISTVCSCTM LFVEKQKRKI LRFPVDGLRD DTAPMLGGDD 


SD 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080185 Genomic DNA. Translation: CCD61822.1.
RefSeqNP_498604.2. NM_066203.7.
UniGeneCel.10942.

3D structure databases

ProteinModelPortalQ10944.
SMRQ10944. Positions 31-363.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.B0361.7.

Proteomic databases

PaxDbQ10944.
PRIDEQ10944.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0361.7; B0361.7; WBGene00015161.
GeneID176030.
KEGGcel:CELE_B0361.7.
UCSCB0361.7. c. elegans.

Organism-specific databases

CTD176030.
WormBaseB0361.7; CE32100; WBGene00015161; pho-5.

Phylogenomic databases

eggNOGNOG85977.
GeneTreeENSGT00530000062956.
HOGENOMHOG000020614.
InParanoidQ10944.
KOK14410.
OMATLEYVHT.
OrthoDBEOG7GXPBJ.
PhylomeDBQ10944.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio890816.

Entry information

Entry namePHO5_CAEEL
AccessionPrimary (citable) accession number: Q10944
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: June 11, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase