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Protein

Putative acid phosphatase 5

Gene

pho-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401NucleophileBy similarity
Active sitei279 – 2791Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acid phosphatase 5 (EC:3.1.3.2)
Gene namesi
Name:pho-5
ORF Names:B0361.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0361.7; CE32100; WBGene00015161; pho-5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313Sequence AnalysisAdd
BLAST
Chaini14 – 422409Putative acid phosphatase 5PRO_0000023968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 363By similarity
Disulfide bondi205 ↔ 302By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)1 Publication
Disulfide bondi338 ↔ 342By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ10944.
PRIDEiQ10944.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0361.7.

Structurei

3D structure databases

ProteinModelPortaliQ10944.
SMRiQ10944. Positions 31-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85977.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000020614.
InParanoidiQ10944.
KOiK14410.
OMAiMSAQANM.
OrthoDBiEOG7GXPBJ.
PhylomeDBiQ10944.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLVLLIG ASGINAVVYK EVPIQANTDT LEYVHTVWRH GDRTPAELLF
60 70 80 90 100
PDDITKWPEG LGELTEQGAA QQYRLGQWLK RRYGSWLGEK FNRNAIYIRS
110 120 130 140 150
SDYNRTLMSA QANMAGLFPP KYPIAGGLMW QPIPVHTISK PTDKELYEEA
160 170 180 190 200
SCPTAEIEMN AQWKSTKANG IRKKFARELS FFSQKLNLPN MELKATWRIF
210 220 230 240 250
DNLFCEKQNN ITWPSWMNSS IFERVDQLYN EVSQLEFHTD TLRRLRGGTL
260 270 280 290 300
LEEIFHRFSD KASGSLGKEA KFYAYSAHDS TIAALLATLG VFYDIYPKYA
310 320 330 340 350
TCLLIEMHKL ANETRLIRVF HKNETDIDRL IEYSIPGCDD PCTLQKLGDD
360 370 380 390 400
LKKYFPEDWE AECGLKTSFQ FIYLVIISIL VISTVCSCTM LFVEKQKRKI
410 420
LRFPVDGLRD DTAPMLGGDD SD
Length:422
Mass (Da):48,409
Last modified:May 30, 2003 - v3
Checksum:i3E29FACB4FAE0CAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080185 Genomic DNA. Translation: CCD61822.1.
RefSeqiNP_498604.2. NM_066203.7.
UniGeneiCel.10942.

Genome annotation databases

EnsemblMetazoaiB0361.7; B0361.7; WBGene00015161.
GeneIDi176030.
KEGGicel:CELE_B0361.7.
UCSCiB0361.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080185 Genomic DNA. Translation: CCD61822.1.
RefSeqiNP_498604.2. NM_066203.7.
UniGeneiCel.10942.

3D structure databases

ProteinModelPortaliQ10944.
SMRiQ10944. Positions 31-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0361.7.

Proteomic databases

PaxDbiQ10944.
PRIDEiQ10944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0361.7; B0361.7; WBGene00015161.
GeneIDi176030.
KEGGicel:CELE_B0361.7.
UCSCiB0361.7. c. elegans.

Organism-specific databases

CTDi176030.
WormBaseiB0361.7; CE32100; WBGene00015161; pho-5.

Phylogenomic databases

eggNOGiNOG85977.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000020614.
InParanoidiQ10944.
KOiK14410.
OMAiMSAQANM.
OrthoDBiEOG7GXPBJ.
PhylomeDBiQ10944.

Miscellaneous databases

NextBioi890816.
PROiQ10944.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiPHO5_CAEEL
AccessioniPrimary (citable) accession number: Q10944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: April 29, 2015
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.